1. Metabolic Enzyme/Protease
    Anti-infection
  2. Adenosine Deaminase
    Phosphodiesterase (PDE)
    Influenza Virus
  3. EHNA hydrochloride

EHNA hydrochloride 

Cat. No.: HY-103160A Purity: >98.0%
Handling Instructions

EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

For research use only. We do not sell to patients.

EHNA hydrochloride Chemical Structure

EHNA hydrochloride Chemical Structure

CAS No. : 58337-38-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 86 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects[1][2].

IC50 & Target[1]

hPDE2A

0.8 μM (IC50)

In Vitro

EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity[2].
EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity[2].
EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts[3].

Molecular Weight

313.83

Formula

C₁₄H₂₄ClN₅O

CAS No.

58337-38-5

SMILES

CCCCCC[[email protected]@](N1C2=C(C(N)=NC=N2)N=C1)([H])[[email protected]](O)C.[Relative stereochemistry].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

EHNAAdenosine DeaminasePhosphodiesterase (PDE)Influenza VirusPhosphodiesterasePDEADAantiviralantitumourantiarrhythmicInhibitorinhibitorinhibit

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EHNA hydrochloride
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HY-103160A
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