1-Deazaadenosine
Based on 1 Customer Validation
1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders.
For research use only. We do not sell to patients.
- Purity: 98.9%
- CAS No.: 14432-09-8
- Formula: C11H14N4O4
- Molecular Weight:266.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | ED50 |
>100 μM
Compound: 9
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In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB.
In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB.
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[PMID: 7562937] |
| Vero | EC50 |
>400 μg/mL
Compound: C-c3Ado
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Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells
Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells
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[PMID: 9171871] |
| Vero | EC50 |
0.2 μg/mL
Compound: C-c3Ado
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Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells
Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells
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[PMID: 9171871] |
| Vero | EC50 |
0.7 μg/mL
Compound: C-c3Ado
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Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells
Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells
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[PMID: 9171871] |
| Vero | EC50 |
4 μg/mL
Compound: C-c3Ado
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Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells
Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells
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[PMID: 9171871] |
| Vero | EC50 |
4 μg/mL
Compound: C-c3Ado
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Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells
Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells
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[PMID: 9171871] |
1-Deazaadenosine shows good activity in vitro as inhibitor of HeLa, KB, P388, and L1210 leukemia cell line growth, with ID50 values ranging from 0.34 μM (KB) to 1.8 μM (P388)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14432-09-8
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Appearance Solid
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Molecular Weight 266.25
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Formula C11H14N4O4
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Color White to off-white
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SMILES
NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)C=N2)=NC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Deazaadenosine Related Classifications
HY-103159 Related Classifications
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