1-Deazaadenosine
Based on 1 Customer Validation
1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.9%
- CAS 番号: 14432-09-8
- 分子式: C11H14N4O4
- 分子量:266.25
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-A0006
Pentostatin -
HY-115686
8-Azaadenosine -
HY-103160A
EHNA hydrochloride -
HY-N7368
Hibifolin -
HY-14917
Capadenoson -
HY-103673
AMPD2 inhibitor 1 -
HY-103160AR
EHNA hydrochloride (Standard) -
HY-103237
L-Adenosine -
HY-A0006R
Pentostatin (Standard) -
HY-N7368R
Hibifolin (Standard) -
HY-103673R
AMPD2 inhibitor 1 (Standard) -
HY-103237R
L-Adenosine (Standard)
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | ED50 |
>100 μM
Compound: 9
|
In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB.
In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB.
|
[PMID: 7562937] |
| Vero | EC50 |
>400 μg/mL
Compound: C-c3Ado
|
Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells
Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells
|
[PMID: 9171871] |
| Vero | EC50 |
0.2 μg/mL
Compound: C-c3Ado
|
Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells
Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells
|
[PMID: 9171871] |
| Vero | EC50 |
0.7 μg/mL
Compound: C-c3Ado
|
Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells
Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells
|
[PMID: 9171871] |
| Vero | EC50 |
4 μg/mL
Compound: C-c3Ado
|
Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells
Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells
|
[PMID: 9171871] |
| Vero | EC50 |
4 μg/mL
Compound: C-c3Ado
|
Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells
Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells
|
[PMID: 9171871] |
体外実験
1-Deazaadenosine shows good activity in vitro as inhibitor of HeLa, KB, P388, and L1210 leukemia cell line growth, with ID50 values ranging from 0.34 μM (KB) to 1.8 μM (P388)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 14432-09-8
-
性状 Solid
-
分子量 266.25
-
分子式 C11H14N4O4
-
Color White to off-white
-
SMILES
NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)C=N2)=NC=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
-
データシート (269 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
1-Deazaadenosine 関連分類
HY-103159 関連分類
Powered by Bioz