14432-09-8
14432-09-8
Chemical Structure
1-Deazaadenosine
- CAS No.: 14432-09-8
- Formula:C11H14N4O4
- Molecular Weight:266.25
IUPAC Name: (2R,3R,4S,5R)-2-(7-amino-3H-imidazo[4,5-b]pyridin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: NVUDDRWKCUAERS-PNHWDRBUSA-N
SMILES: NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)C=N2)=NC=C1
Biological Activity: 1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Deazaadenosine | 98.9% | 1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-103237RL-Adenosine (Standard) -
Similarity Score 0.81
HY-1526729-(β-D-Xylofuranosyl)adenine -
Similarity Score 0.81
HY-B0228S1Adenosine-13C5 -
Similarity Score 0.81
HY-B0228S11Adenosine-15N5 -
Similarity Score 0.81
HY-B0228S13Adenosine-13C10 -
Similarity Score 0.81
HY-B0228S4Adenosine-1′-13C -
Similarity Score 0.81
HY-B0228S5Adenosine-13C -
Similarity Score 0.81
HY-B0228S9Adenosine-13C10,15N5 -
Similarity Score 0.81
HY-B0277Vidarabine -
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References
- [1]. Cristalli G, et al.Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res.
- [2]. Cristalli G, et al.Improved synthesis and antitumor activity of 1-deazaadenosine.J Med Chem. 1987 Sep;30(9):1686-8. [Content Brief]
