Adenosine-13C10,15N5
Based on 1 Customer Validation
Adenosine-13C10,15N5 is the 13C and 15N labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 202406-75-5
- Formula: 13C10H1315N5O4
- Molecular Weight:282.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 202406-75-5
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Unlabeled Cas 58-61-7
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Appearance Solid
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Molecular Weight 282.13
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Formula 13C10H1315N5O4
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Color White to off-white
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SMILES
[15NH2][13C]1=[13C]([15N]=[13CH]2)[13C]([15N]2[13C@H]3[13C@H](O)[13C@H](O)[13C@@H]([13CH2]O)O3)=[15N][13CH]=[15N]1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 33 mg/mL (116.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Content Brief]
[3]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 200714(7):1315-1323. [Content Brief]
[4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 201941(2):829-838. [Content Brief]
[5]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009111(4):904-915. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.5445 mL | 17.7223 mL | 35.4447 mL | 88.6116 mL |
| 5 mM | 0.7089 mL | 3.5445 mL | 7.0889 mL | 17.7223 mL | |
| 10 mM | 0.3544 mL | 1.7722 mL | 3.5445 mL | 8.8612 mL | |
| 15 mM | 0.2363 mL | 1.1815 mL | 2.3630 mL | 5.9074 mL | |
| 20 mM | 0.1772 mL | 0.8861 mL | 1.7722 mL | 4.4306 mL | |
| 25 mM | 0.1418 mL | 0.7089 mL | 1.4178 mL | 3.5445 mL | |
| 30 mM | 0.1181 mL | 0.5907 mL | 1.1815 mL | 2.9537 mL | |
| 40 mM | 0.0886 mL | 0.4431 mL | 0.8861 mL | 2.2153 mL | |
| 50 mM | 0.0709 mL | 0.3544 mL | 0.7089 mL | 1.7722 mL | |
| 60 mM | 0.0591 mL | 0.2954 mL | 0.5907 mL | 1.4769 mL | |
| 80 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1076 mL | |
| 100 mM | 0.0354 mL | 0.1772 mL | 0.3544 mL | 0.8861 mL |
Adenosine-13C10,15N5 Related Classifications
HY-B0228S9 Related Classifications
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