Adenosine-¹³C₁₀,¹⁵N₅ 

Adenosine-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

282.13

¹³C₁₀H₁₃¹⁵N₅O₄

202406-75-5

Solid

White to off-white

[15NH2][13C]1=[13C]([15N]=[13CH]2)[13C]([15N]2[13C@H]3[13C@H](O)[13C@H](O)[13C@@H]([13CH2]O)O3)=[15N][13CH]=[15N]1

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625.  [Content Brief]

  [3]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 200714(7):1315-1323.  [Content Brief]

  [4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 201941(2):829-838.  [Content Brief]

  [5]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009111(4):904-915.  [Content Brief]