1. Cell Cycle/DNA Damage
    Autophagy
    Apoptosis
    Metabolic Enzyme/Protease
  2. Nucleoside Antimetabolite/Analog
    Autophagy
    Apoptosis
    Endogenous Metabolite
  3. Adenosine

Adenosine (Synonyms: Adenine riboside; D-Adenosine)

Cat. No.: HY-B0228 Purity: 99.92%
Handling Instructions

Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

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Adenosine Chemical Structure

Adenosine Chemical Structure

CAS No. : 58-61-7

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Adenosine purchased from MCE. Usage Cited in: Int J Mol Med. 2016 Sep;38(3):969-75.

    Effects of Adenosine and CGS21680 on CD39 and CD73 expression. (A) Adenosine and CGS21680 promote the expression of CD39. (B) Adenosine and CGS21680 promote the expression of CD73. GAPDH is used as an internal reference.
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    Description

    Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Adenosine (Adenine riboside) acts on four G-protein coupled receptors: two of them, A1 and A3, are primarily coupled to Gi family G proteins; and two of them, A2A and A2B, are mostly coupled to Gs like G proteins. These receptors are antagonized by xanthines including caffeine. Via these receptors it affects many cells and organs, usually having a cytoprotective function[2].
    Adenosine is an extracellular signaling molecule that is generated from its precursor molecules 5’-adenosine triphosphate (ATP) and 5’-adenosine monophosphate (AMP)[3].
    Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations.Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells[4].
    Adenosine induces apoptosis in a variety of cancer cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells. In HepG2 cell lines, Adenosine -induced AMPK/mTOR pathway activation partially blocked ER stress and decreased apoptotic cell death[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    267.24

    Formula

    C₁₀H₁₃N₅O₄

    CAS No.

    58-61-7

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (124.72 mM; Need ultrasonic)

    H2O : ≥ 6.67 mg/mL (24.96 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7420 mL 18.7098 mL 37.4195 mL
    5 mM 0.7484 mL 3.7420 mL 7.4839 mL
    10 mM 0.3742 mL 1.8710 mL 3.7420 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    AdenosineAdenine riboside D-AdenosineNucleoside Antimetabolite/AnalogAutophagyApoptosisEndogenous MetaboliteGPCRendogenousneuronalvascularplateletaggregationbloodcellregulationInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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