1. Cell Cycle/DNA Damage
    Autophagy
    Metabolic Enzyme/Protease
  2. Nucleoside Antimetabolite/Analog
    Autophagy
    Endogenous Metabolite
  3. Adenosine

Adenosine (Synonyms: Adenine riboside; D-Adenosine)

Cat. No.: HY-B0228 Purity: 99.84%
Handling Instructions

Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.

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Adenosine Chemical Structure

Adenosine Chemical Structure

CAS No. : 58-61-7

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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5 g USD 96 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Adenosine purchased from MCE. Usage Cited in: Int J Mol Med. 2016 Sep;38(3):969-75.

    Effects of Adenosine and CGS21680 on CD39 and CD73 expression. (A) Adenosine and CGS21680 promote the expression of CD39. (B) Adenosine and CGS21680 promote the expression of CD73. GAPDH is used as an internal reference.
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    Description

    Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Target: Nucleoside antimetabolite/analog Adenosine plays an important role in biochemical processes, such as energy transfer — as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) — as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It is also an inhibitory neurotransmitter, believed to play a role in promoting sleep and suppressing arousal. Adenosine also plays a role in regulation of blood flow to various organs through vasodilation. Adenosine is an endogenous purine nucleoside that modulates many physiological processes. Cellular signaling by adenosine occurs through four known adenosine receptor subtypes. Extracellular adenosine concentrations from normal cells are approximately 300 nM; however, in response to cellular damage (e.g. in inflammatory or ischemic tissue), these concentrations are quickly elevated (600–1,200 nM). Thus, in regard to stress or injury, the function of adenosine is primarily that of cytoprotection preventing tissue damage during instances of hypoxia, ischemia, and seizure activity. Activation of A2A receptors produces a constellation of responses that in general can be classified as anti-inflammatory.

    IC50 & Target

    Human Endogenous Metabolite

     

    Clinical Trial
    Molecular Weight

    267.24

    Formula

    C₁₀H₁₃N₅O₄

    CAS No.

    58-61-7

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (124.72 mM; Need ultrasonic)

    H2O : ≥ 6.67 mg/mL (24.96 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7420 mL 18.7098 mL 37.4195 mL
    5 mM 0.7484 mL 3.7420 mL 7.4839 mL
    10 mM 0.3742 mL 1.8710 mL 3.7420 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    AdenosineAdenine ribosideD-AdenosineNucleoside Antimetabolite/AnalogAutophagyEndogenous MetaboliteInhibitorinhibitorinhibit

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    Product name:
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