Adenosine 5'-diphosphate disodium
Based on 9 publication(s) in Google Scholar
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 16178-48-6
- Formula: C10H13N5Na2O10P2
- Molecular Weight:471.16
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Adenosine 5'-diphosphate disodium
More- Nature. 2026 Jan;649(8096):423-431. [Abstract]
- Adv Mater. 2025 Apr;37(17):e2416349. [Abstract]
- Redox Biol. 2024 Aug:74:103225. [Abstract]
- Acta Pharm Sin B. 2025 Oct 24.
- Chem Eng J. 2026 Feb 12.
- Phytomedicine. 2025 Dec:149:157553. [Abstract]
- Int J Biol Macromol. 2025 Jun;311(Pt 3):144068. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Cell Biomater. 2026 Mar 6.
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Biological Activity
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Human Endogenous Metabolite |
Adenosine 5'-diphosphate disodium (10 μmol/L) induces human platelets aggregation and [Ca2+]i increasing in platelets, B10 cells, and P2Y1-transfected cells[1]. Adenosine 5'-diphosphate disodium (5 μmol/L) increases cAMP levels in human platelets and in B10 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16178-48-6
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Appearance Solid
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Molecular Weight 471.16
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Formula C10H13N5Na2O10P2
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Color White to off-white
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SMILES
O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Synonyms
Adenosine diphosphate disodium; ADP disodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (9)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jan;649(8096):423-431. PMID: 41193806 -
Adv Mater
2025 Apr;37(17):e2416349. PMID: 40025988 -
Redox Biol
FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. [Abstract]2024 Aug:74:103225. PMID: 38875957
Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Aug:74:103225. [Abstract]
ADP (5 mM; 1 h). Representative Western blots show the protein levels of p-PI3K, PI3K, p-AKT, AKT, p-NRF2, NRF2, GSDMD, and GSDMD-N in different groups.
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Phytomedicine
Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]2025 Dec:149:157553. PMID: 41273866
Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553. [Abstract]
Flow cytometry analysis of CD61 and CD62P expression in ADP (20 μM; 10 min) -stimulated platelets after glycyrrhizin treatment.
Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553. [Abstract]
Quantitative analysis of the adhesion thickness of platelets on fibrinogen-coated surfaces after ADP (20 μM) activation, with or without glycyrrhizin treatment.
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Int J Biol Macromol
FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]2025 Jun;311(Pt 3):144068. PMID: 40345291 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Solvent & Solubility
H2O : 100 mg/mL (212.24 mM; Need ultrasonic)
DMSO : 5 mg/mL (10.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.5 mg/mL (1.06 mM); Clear solution
This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
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- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Hechler B, et al. The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation. Blood. 1998 Jul 1;92(1):152-9. [Content Brief]
[2]. Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.1224 mL | 10.6121 mL | 21.2242 mL | 53.0605 mL |
| 5 mM | 0.4245 mL | 2.1224 mL | 4.2448 mL | 10.6121 mL | |
| 10 mM | 0.2122 mL | 1.0612 mL | 2.1224 mL | 5.3061 mL | |
| H2O | 15 mM | 0.1415 mL | 0.7075 mL | 1.4149 mL | 3.5374 mL |
| 20 mM | 0.1061 mL | 0.5306 mL | 1.0612 mL | 2.6530 mL | |
| 25 mM | 0.0849 mL | 0.4245 mL | 0.8490 mL | 2.1224 mL | |
| 30 mM | 0.0707 mL | 0.3537 mL | 0.7075 mL | 1.7687 mL | |
| 40 mM | 0.0531 mL | 0.2653 mL | 0.5306 mL | 1.3265 mL | |
| 50 mM | 0.0424 mL | 0.2122 mL | 0.4245 mL | 1.0612 mL | |
| 60 mM | 0.0354 mL | 0.1769 mL | 0.3537 mL | 0.8843 mL | |
| 80 mM | 0.0265 mL | 0.1327 mL | 0.2653 mL | 0.6633 mL | |
| 100 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5306 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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