2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Adenosine 5'-diphosphate disodium

Adenosine 5'-diphosphate disodium  (Synonyms: Adenosine diphosphate disodium; ADP disodium)

Cat. No.: HY-D0199 Purity: 99.86%
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Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.

For research use only. We do not sell to patients.

CAS No. : 16178-48-6

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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Adenosine 5'-diphosphate disodium:

Adenosine 5'-diphosphate disodium Related Antibodies

Top Publications Citing Use of Products

    Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553.  [Abstract]

    Flow cytometry analysis of CD61 and CD62P expression in ADP (20 μM; 10 min) -stimulated platelets after glycyrrhizin treatment.

    Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553.  [Abstract]

    Quantitative analysis of the adhesion thickness of platelets on fibrinogen-coated surfaces after ADP (20 μM) activation, with or without glycyrrhizin treatment.

    Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Jun 8:74:103225.  [Abstract]

    ADP (5 mM; 1 h). Representative Western blots show the protein levels of p-PI3K, PI3K, p-AKT, AKT, p-NRF2, NRF2, GSDMD, and GSDMD-N in different groups.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Adenosine 5'-diphosphate disodium (10 μmol/L) induces human platelets aggregation and [Ca2+]i increasing in platelets, B10 cells, and P2Y1-transfected cells[1].
    Adenosine 5'-diphosphate disodium (5 μmol/L) increases cAMP levels in human platelets and in B10 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Adenosine 5'-diphosphate disodium Related Antibodies
    Molecular Weight

    471.16

    Formula

    C10H13N5Na2O10P2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (212.24 mM; Need ultrasonic)

    DMSO : 5 mg/mL (10.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1224 mL 10.6121 mL 21.2242 mL
    5 mM 0.4245 mL 2.1224 mL 4.2448 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 0.5 mg/mL (1.06 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 0.5 mg/mL (1.06 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

    g

    Dosing volume
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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    SDS (396 KB)

    COA (253 KB) RP-HPLC (205 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.1224 mL 10.6121 mL 21.2242 mL 53.0605 mL
    5 mM 0.4245 mL 2.1224 mL 4.2448 mL 10.6121 mL
    10 mM 0.2122 mL 1.0612 mL 2.1224 mL 5.3061 mL
    H2O 15 mM 0.1415 mL 0.7075 mL 1.4149 mL 3.5374 mL
    20 mM 0.1061 mL 0.5306 mL 1.0612 mL 2.6530 mL
    25 mM 0.0849 mL 0.4245 mL 0.8490 mL 2.1224 mL
    30 mM 0.0707 mL 0.3537 mL 0.7075 mL 1.7687 mL
    40 mM 0.0531 mL 0.2653 mL 0.5306 mL 1.3265 mL
    50 mM 0.0424 mL 0.2122 mL 0.4245 mL 1.0612 mL
    60 mM 0.0354 mL 0.1769 mL 0.3537 mL 0.8843 mL
    80 mM 0.0265 mL 0.1327 mL 0.2653 mL 0.6633 mL
    100 mM 0.0212 mL 0.1061 mL 0.2122 mL 0.5306 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Adenosine 5'-diphosphate disodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Adenosine 5'-diphosphate disodium16178-48-6Adenosine diphosphate disodium ADP disodiumEndogenous MetaboliteATPdephosphorylationplatelet aggregationarterial thrombosisInhibitorinhibitorinhibit

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