Cat. No.: HY-D0199

Adenosine 5'-diphosphate disodium

Name: Adenosine 5'-diphosphate disodium
Brand: MedChemExpress
SKU: HY-D0199
Price: 25.00 USD
Availability: InStock
Rating: 5 (14 reviews)

(Synonyms: Adenosine diphosphate disodium; ADP disodium)

14 Cited Publications

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Based on 14 publication(s) in Google Scholar

Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.

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Pureté : 99.86%
CAS No.: 16178-48-6
Formule: C₁₀H₁₃N₅Na₂O₁₀P₂
Masse moléculaire:471.16

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Adenosine 5'-diphosphate disodium Chemical Structure

CAS No.: 16178-48-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (14)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

Human Endogenous Metabolite

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In Vitro

Adenosine 5'-diphosphate disodium (10 μmol/L) induces human platelets aggregation and [Ca²⁺]i increasing in platelets, B10 cells, and P2Y1-transfected cells^[1].
Adenosine 5'-diphosphate disodium (5 μmol/L) increases cAMP levels in human platelets and in B10 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 16178-48-6
Appearance Solid
Masse moléculaire 471.16
Formule C₁₀H₁₃N₅Na₂O₁₀P₂
Color White to off-white
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
Synonyms

Adenosine diphosphate disodium; ADP disodium
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (14)

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Journal Impact Factor

Nature

Adenosine signalling drives antidepressant actions of ketamine and ECT. [Abstract]

2026 Jan;649(8096):423-431. PMID: 41193806
Adv Mater

Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis. [Abstract]

2025 Apr;37(17):e2416349. PMID: 40025988
Redox Biol

FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. [Abstract]

2024 Aug:74:103225. PMID: 38875957

Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Aug:74:103225. [Abstract]

ADP (5 mM; 1 h). Representative Western blots show the protein levels of p-PI3K, PI3K, p-AKT, AKT, p-NRF2, NRF2, GSDMD, and GSDMD-N in different groups.
Acta Pharm Sin B

2025 Oct 24.
Sci Adv

2026 Aug 14;12(33):eaee9000. PMID: 42585302
Chem Eng J

2026 Feb 12.
Phytomedicine

Liquiritigenin attenuates thrombosis by inhibiting P2Y12R-mediated Src/PLCγ2 signaling and cytoplasmic Ca2+ mobilization in platelets. [Abstract]

2025 Dec:149:157553. PMID: 41273866

Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553. [Abstract]

Flow cytometry analysis of CD61 and CD62P expression in ADP (20 μM; 10 min) -stimulated platelets after glycyrrhizin treatment.

Adenosine 5'-diphosphate disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Dec:149:157553. [Abstract]

Quantitative analysis of the adhesion thickness of platelets on fibrinogen-coated surfaces after ADP (20 μM) activation, with or without glycyrrhizin treatment.
Int J Biol Macromol

FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]

2025 Jun;311(Pt 3):144068. PMID: 40345291
Cell Rep

2026 Oct 27;45(10):118032. PMID: 42776840
Molecules

Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]

2025 Mar 9;30(6):1224. PMID: 40142001
FASEB J

2026 Sep 30;40(18):e72297. PMID: 42776065
bioRxiv

2026 Aug 26.
chemRxiv

2026 Jul 2.
Cell Biomater

2026 Mar 6.

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (212.24 mM; Need ultrasonic)

DMSO : 5 mg/mL (10.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1224 mL

10.6121 mL

21.2242 mL

5 mM

0.4245 mL

2.1224 mL

4.2448 mL

10 mM

0.2122 mL

1.0612 mL

2.1224 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.5 mg/mL (1.06 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.5 mg/mL (1.06 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hechler B, et al. The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation. Blood. 1998 Jul 1;92(1):152-9. [Content Brief]

[2]. Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.1224 mL	10.6121 mL	21.2242 mL	53.0605 mL
	5 mM	0.4245 mL	2.1224 mL	4.2448 mL	10.6121 mL
	10 mM	0.2122 mL	1.0612 mL	2.1224 mL	5.3061 mL
H₂O	15 mM	0.1415 mL	0.7075 mL	1.4149 mL	3.5374 mL
	20 mM	0.1061 mL	0.5306 mL	1.0612 mL	2.6530 mL
	25 mM	0.0849 mL	0.4245 mL	0.8490 mL	2.1224 mL
	30 mM	0.0707 mL	0.3537 mL	0.7075 mL	1.7687 mL
	40 mM	0.0531 mL	0.2653 mL	0.5306 mL	1.3265 mL
	50 mM	0.0424 mL	0.2122 mL	0.4245 mL	1.0612 mL
	60 mM	0.0354 mL	0.1769 mL	0.3537 mL	0.8843 mL
	80 mM	0.0265 mL	0.1327 mL	0.2653 mL	0.6633 mL
	100 mM	0.0212 mL	0.1061 mL	0.2122 mL	0.5306 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Keywords

Adenosine 5'-diphosphate disodium

14 Cited Publications

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Adenosine 5'-diphosphate disodium

Publications Citing Use of MedChemExpress (MCE) Adenosine 5'-diphosphate disodium

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