Cefotaxime  (Synonyms: Cefotaxim; HR-756)

Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria^{[1][2][3][4][2]}.

Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

455.47

Solid

C₁₆H₁₇N₅O₇S₂

63527-52-6

O=C(C(N12)=C(COC(C)=O)CS[[email protected]]2([H])[[email protected]](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O

Room temperature in continental US; may vary elsewhere.

• [1]. Hee-Chang Jang, et al. In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis. PLoS One. 2014 Jun 30;9(6):e101118.  [Content Brief]

  [2]. Woodfield JC, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9.  [Content Brief]

  [3]. Scholz H, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7.  [Content Brief]

  [4]. Gums JG, et al. Differences between ceftriaxone and cefotaxime: microbiological inconsistencies. Ann Pharmacother. 2008 Jan;42(1):71-9.  [Content Brief]

  [5]. E L Francke, et al. Use of cefotaxime, a beta-lactamase stable cephalosporin, in the therapy of serious infections, including those due to multiresistant organisms. Am J Med. 1981 Sep;71(3):435-42.  [Content Brief]