1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefotaxime

Cefotaxime (Synonyms: Cefotaxim; HR-756)

Cat. No.: HY-A0088A Purity: 99.55%
Handling Instructions

Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

Cefotaxime Chemical Structure

Cefotaxime Chemical Structure

CAS No. : 63527-52-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
250 mg USD 100 In-stock
Estimated Time of Arrival: December 31
500 mg USD 135 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][2].

In Vitro

Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, specific pathogen free, 8-week-old BALB/c mice[4].
Dosage: 30 mg/kg.
Administration: IP every 6 h.
Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
Clinical Trial
Molecular Weight

455.47

Formula

C₁₆H₁₇N₅O₇S₂

CAS No.

63527-52-6

SMILES

O=C(C(N12)=C(COC(C)=O)CS[[email protected]]2([H])[[email protected]](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (548.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1955 mL 10.9777 mL 21.9553 mL
5 mM 0.4391 mL 2.1955 mL 4.3911 mL
10 mM 0.2196 mL 1.0978 mL 2.1955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CefotaximeCefotaxim HR-756HR756HR 756HR-756BacterialAntibioticInhibitorinhibitorinhibit

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Cefotaxime
Cat. No.:
HY-A0088A
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