38874-46-3
Chemical Structure
8-Azanebularine
- CAS No.: 38874-46-3
- Formula:C9H11N5O4
- Molecular Weight:253.21
IUPAC Name: (2R,3R,4S,5R)-2-(3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: XOUCEKYAMMLQRC-JXOAFFINSA-N
SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2
Biological Activity: 8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].
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8-Azanebularine | 99.33% | 8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction. | ||||||||||||||||||||
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Keywords
