Solutol HS-15
Based on 24 publication(s) in Google Scholar
Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.
For research use only. We do not sell to patients.
- CAS No.: 61909-81-7
- Formula: (C2H4O)nC18H36O3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Solutol HS-15
More- Nature. 2024 Apr;628(8009):835-843. [Abstract]
- Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. [Abstract]
- Cancer Cell. 2020 Dec 14;38(6):844-856.e7. [Abstract]
- Nat Immunol. 2025 Apr 11. [Abstract]
- Nat Commun. 2023 Sep 18;14(1):5666. [Abstract]
- Nat Chem Biol. 2025 May 26. [Abstract]
- Carbohydr Polym. 2025 Sep 1:363:123707. [Abstract]
- Cell Rep Med. 2024 Nov 25:101837. [Abstract]
- Cell Rep Med. 2023 Apr 18;4(4):101015. [Abstract]
- ACS Appl Mater Interfaces. 2025 Dec 31. [Abstract]
- Eur J Med Chem. 2022 Mar 15:232:114166. [Abstract]
- Pharmaceutics. 2025 Dec 11;17(12):1599. [Abstract]
- Front Pharmacol. 2021 Nov 11;12:773126. [Abstract]
- Molecules. 2022 Aug 25;27(17):5448. [Abstract]
- Eur J Pharm Biopharm. 2024 Feb:195:114179. [Abstract]
- ACS Infect Dis. 2025 Jan 10;11(1):181-196. [Abstract]
- Cancer Med. 2025 Nov;14(22):e71399. [Abstract]
- Invest New Drugs. 2022 Oct;40(5):922-933. [Abstract]
- Biomed Chromatogr. 2026 Jun;40(6):e70467. [Abstract]
- Georgetown University. 2026.
- University of Toronto. 2026.
- McGill University. 2025.
- Res Sq. 2025 Feb 11:rs.3.rs-4138879. [Abstract]
- Res Sq. 2023 Apr 26:rs.3.rs-2861359. [Abstract]
Biological Activity
Solutol HS-15 is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Solutol HS-15 has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61909-81-7
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Appearance Oil
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Formula (C2H4O)nC18H36O3
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Color Colorless to off-white
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SMILES
CCCCCCC(O)CCCCCCCCCCC(OCCO)=O.[n]
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Synonyms
Polyethylene glycol 12-hydroxystearate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (24)
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Journal Impact Factor
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Most Recent
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Nature
2024 Apr;628(8009):835-843. PMID: 38600381 -
Cancer Cell
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. [Abstract]2022 Dec 12;40(12):1566-1582.e10. PMID: 36306790 -
Cancer Cell
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. [Abstract]2020 Dec 14;38(6):844-856.e7. PMID: 33186520 -
Nat Immunol
2025 Apr 11. PMID: 40217111 -
Nat Commun
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. [Abstract]2023 Sep 18;14(1):5666. PMID: 37723181 -
Nat Chem Biol
2025 May 26. PMID: 40419770 -
Carbohydr Polym
A rapid and efficient microenvironment improving hyaluronic acid microneedle dressing for burn wound synergistic treatment. [Abstract]2025 Sep 1:363:123707. PMID: 40441824 -
Cell Rep Med
Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents. [Abstract]2024 Nov 25:101837. PMID: 39615486 -
Cell Rep Med
A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer. [Abstract]2023 Apr 18;4(4):101015. PMID: 37075701 -
ACS Appl Mater Interfaces
Mitochondrial Rapid Accumulation and Self-Enhanced Penetrating Nanomedicine for Tumor Multi-role Treatment. [Abstract]2025 Dec 31. PMID: 41476371 -
Eur J Med Chem
Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. [Abstract]2022 Mar 15:232:114166. PMID: 35152092 -
Pharmaceutics
Therapeutic Delivery of Phloretin by Mixed Emulsifier-Stabilized Nanoemulsion Alleviated Cerebral Ischemia/Reperfusion Injury. [Abstract]2025 Dec 11;17(12):1599. PMID: 41471114 -
Front Pharmacol
Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy. [Abstract]2021 Nov 11;12:773126. PMID: 34899329 -
Molecules
Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study. [Abstract]2022 Aug 25;27(17):5448. PMID: 36080214 -
Eur J Pharm Biopharm
Cysteine-modified PEGylated nanoparticles for targeted delivery of methylprednisolone to pancreatitis. [Abstract]2024 Feb:195:114179. PMID: 38199584 -
ACS Infect Dis
nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice. [Abstract]2025 Jan 10;11(1):181-196. PMID: 39737550 -
Cancer Med
CDH11 Contributes to Bladder Cancer Progression via Regulation of Mitochondrial Energy Metabolism. [Abstract]2025 Nov;14(22):e71399. PMID: 41263259 -
Invest New Drugs
MY11 exerts antitumor effects through activation of the NF-κB/PUMA signaling pathway in breast cancer. [Abstract]2022 Oct;40(5):922-933. PMID: 35759135 -
Biomed Chromatogr
LC-MS/MS Determination of the Absorption and Distribution Dynamics of the Bioactive Alkaloid Dendrobine Derived From Chinese Dendrobium nobile. [Abstract]2026 Jun;40(6):e70467. PMID: 42044949 -
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Res Sq
2025 Feb 11:rs.3.rs-4138879. PMID: 39989975 -
Res Sq
2023 Apr 26:rs.3.rs-2861359. PMID: 37162820
Solvent & Solubility
Ethanol : 100 mg/mL (Need ultrasonic)
H2O : 25 mg/mL (Need ultrasonic)
Protocol
For both MTS and LDH cell viability assays, cells are seeded at a density of 1×104 cells on 96-well plates and cultured for a minimum of 24 h. Solutol HS-15 (in 25 mM HBSS:HEPES, pH 7.4) solutions are applied at concentrations above and below the critical micelle concentration (CMC) (0.01 mM to 20 mM) and cytotoxicity is determined using the MTS and LDH assays. 25 mM HBSS:HEPES is used as a negative control and Triton-X 100 (3 mM) as a positive control. Following 3 h incubation, the MTS reagent in media and LDH working solution are added to the cells and the cells are incubated for a further 3 h at 37°C[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solutol HS-15 Related Classifications
HY-Y1893 Related Classifications
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