Solutol HS-15
Based on 26 publication(s) in Google Scholar
Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 61909-81-7
- Formel: (C2H4O)nC18H36O3
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-Y0873A
PEG400 -
HY-Y0873
PEG300Neutral Polymer -
HY-101103
HP-β-CDCo-solvent -
HY-Y1890
Cremophor EL-40Surfactant -
HY-17031
SBE-β-CDExcipient -
HY-148439
DaraxonrasibRAS(ON) Inhibitor -
HY-Y1891
Tween 80 -
HY-Y0320
Dimethyl sulfoxide, meets analytical specification of Ch.P.Aprotic Solvent -
HY-W042416
N,N-DimethylacetamideAnti-inflammatory agent -
HY-Y1275
N-MethylpyrrolidoneFive-membered Cyclic Amide -
HY-Y1888
Corn oil -
HY-10219
RapamycinmTOR Inhibitor
Publications Citing Use of MedChemExpress (MCE) Solutol HS-15
More- Nature. 2024 Apr;628(8009):835-843. [Abstract]
- Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. [Abstract]
- Cancer Cell. 2020 Dec 14;38(6):844-856.e7. [Abstract]
- Nat Immunol. 2025 Apr 11. [Abstract]
- Nat Commun. 2023 Sep 18;14(1):5666. [Abstract]
- Nat Chem Biol. 2025 May 26. [Abstract]
- Cell Rep Med. 2024 Dec 17;5(12):101837. [Abstract]
- Cell Rep Med. 2023 Apr 18;4(4):101015. [Abstract]
- Carbohydr Polym. 2025 Sep 1:363:123707. [Abstract]
- Adv Healthc Mater. 2026 Aug;15(30):e71409.
- ACS Appl Mater Interfaces. 2025 Dec 31. [Abstract]
- Pharmaceutics. 2025 Dec 11;17(12):1599. [Abstract]
- Eur J Med Chem. 2022 Mar 15:232:114166. [Abstract]
- Front Pharmacol. 2021 Nov 11;12:773126. [Abstract]
- Molecules. 2022 Aug 25;27(17):5448. [Abstract]
- Eur J Pharm Biopharm. 2024 Feb:195:114179. [Abstract]
- ACS Infect Dis. 2025 Jan 10;11(1):181-196. [Abstract]
- Cancer Med. 2025 Nov;14(22):e71399. [Abstract]
- Invest New Drugs. 2022 Oct;40(5):922-933. [Abstract]
- Biomed Chromatogr. 2026 Jun;40(6):e70467. [Abstract]
- The University of Tennessee Health Science Center. 2026.
- Georgetown University. 2026.
- University of Toronto. 2026.
- McGill University. 2025.
- Res Sq. 2025 Feb 11:rs.3.rs-4138879. [Abstract]
- Res Sq. 2023 Apr 26:rs.3.rs-2861359. [Abstract]
Biologische Aktivität
Beschreibung
In Vitro
Solutol HS-15 is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Solutol HS-15 has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 61909-81-7
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Appearance Oil
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Formel (C2H4O)nC18H36O3
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Color Colorless to off-white
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SMILES
OCCOC(CCCCCCCCCCC(O)CCCCCC)=O.[n]
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Synonyms
Polyethylene glycol 12-hydroxystearate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (26)
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Journal Impact Factor
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Most Recent
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Nature
2024 Apr;628(8009):835-843. PMID: 38600381 -
Cancer Cell
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. [Abstract]2022 Dec 12;40(12):1566-1582.e10. PMID: 36306790 -
Cancer Cell
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. [Abstract]2020 Dec 14;38(6):844-856.e7. PMID: 33186520 -
Nat Immunol
2025 Apr 11. PMID: 40217111 -
Nat Commun
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. [Abstract]2023 Sep 18;14(1):5666. PMID: 37723181 -
Nat Chem Biol
2025 May 26. PMID: 40419770 -
Cell Rep Med
Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents. [Abstract]2024 Dec 17;5(12):101837. PMID: 39615486 -
Cell Rep Med
A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer. [Abstract]2023 Apr 18;4(4):101015. PMID: 37075701 -
Carbohydr Polym
A rapid and efficient microenvironment improving hyaluronic acid microneedle dressing for burn wound synergistic treatment. [Abstract]2025 Sep 1:363:123707. PMID: 40441824 -
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ACS Appl Mater Interfaces
Mitochondrial Rapid Accumulation and Self-Enhanced Penetrating Nanomedicine for Tumor Multi-role Treatment. [Abstract]2025 Dec 31. PMID: 41476371 -
Pharmaceutics
Therapeutic Delivery of Phloretin by Mixed Emulsifier-Stabilized Nanoemulsion Alleviated Cerebral Ischemia/Reperfusion Injury. [Abstract]2025 Dec 11;17(12):1599. PMID: 41471114 -
Eur J Med Chem
Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. [Abstract]2022 Mar 15:232:114166. PMID: 35152092 -
Front Pharmacol
Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy. [Abstract]2021 Nov 11;12:773126. PMID: 34899329 -
Molecules
Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study. [Abstract]2022 Aug 25;27(17):5448. PMID: 36080214 -
Eur J Pharm Biopharm
Cysteine-modified PEGylated nanoparticles for targeted delivery of methylprednisolone to pancreatitis. [Abstract]2024 Feb:195:114179. PMID: 38199584 -
ACS Infect Dis
nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice. [Abstract]2025 Jan 10;11(1):181-196. PMID: 39737550 -
Cancer Med
CDH11 Contributes to Bladder Cancer Progression via Regulation of Mitochondrial Energy Metabolism. [Abstract]2025 Nov;14(22):e71399. PMID: 41263259 -
Invest New Drugs
MY11 exerts antitumor effects through activation of the NF-κB/PUMA signaling pathway in breast cancer. [Abstract]2022 Oct;40(5):922-933. PMID: 35759135 -
Biomed Chromatogr
LC-MS/MS Determination of the Absorption and Distribution Dynamics of the Bioactive Alkaloid Dendrobine Derived From Chinese Dendrobium nobile. [Abstract]2026 Jun;40(6):e70467. PMID: 42044949 -
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Res Sq
2025 Feb 11:rs.3.rs-4138879. PMID: 39989975 -
Res Sq
2023 Apr 26:rs.3.rs-2861359. PMID: 37162820
Lösungsmittel & Löslichkeit
In Vitro:
Ethanol : 100 mg/mL (Need ultrasonic)
H2O : 100 mg/mL (Need ultrasonic)
Protokoll
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Solutol HS-15 Related Classifications
HY-Y1893 Related Classifications
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