1. JAK/STAT Signaling
    Stem Cell/Wnt
    Apoptosis
  2. STAT
    Apoptosis
  3. Stattic

Stattic 

Cat. No.: HY-13818 Purity: ≥98.0%
Handling Instructions

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice.

For research use only. We do not sell to patients.

Stattic Chemical Structure

Stattic Chemical Structure

CAS No. : 19983-44-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
25 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 156 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 40 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Stattic

    Stattic purchased from MCE. Usage Cited in: Mol Carcinog. 2017 Nov;56(11):2434-2445.

    Cells are treated with the STAT3 inhibitor Stattic. The inhibitory action of Stattic on STAT3 phosphorylation is confirmed by Western blot.

    Stattic purchased from MCE. Usage Cited in: IUBMB Life. 2018 Jan;70(1):81-91.

    A549 cells are treated with TG101348 (3 nM), BMS-911543 (1.5 nM), and Stattic (2.5 lM) for 24 h, and the conditioned media are collected and applied for tube formation assay in HUVECs.

    Stattic purchased from MCE. Usage Cited in: Cell Signal. 2019 Mar;55:65-72.

    Western blotting and densitometric analysis of p-STAT3 in Lo2 cells after 24 h of treatment with the indicated concentrations of the STAT3 inhibitor stattic.

    Stattic purchased from MCE. Usage Cited in: Mol Cancer. 2019 Mar 30;18(1):64.

    Western blot analysis of HCT116 cells alone, IL6-supplemented HCT116, TAMs-co-cultured HCT116 in the presence or absence of Stattic (15 μM).

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    Description

    Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].

    IC50 & Target[1][2]

    STAT3

     

    In Vitro

    Stattic (20 μM; 24 hours) inhibits STAT3 phosphorylation (Y705) and selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines[1].
    Stattic (2.5, 5, 10 μM; for 4 h) significantly reduces the nuclear level of pSTAT3 and survivin in PC3M-1E8 cells at 10 μM. Stattic (2.5-10 μM; for 24 h) inhibits IL-6-induced STAT3 activation in a dose-dependent manner[2].
    Stattic (2.5, 5, 10 μM; for 48 h) suppresses both the growth and induces apoptosis prostate cancer cells (PC3M-1E8 cells) with 10 μM. Stattic does not induce significant cell apoptosis with 2.5 μM, 5 μM[2].
    Stattic (2.5, 5, 10 μM; for 48 h) shows significant S phase accumulation[2].
    Stattic can not lead to significant morphological changes or apoptosis and has little STAT3 phosphorylation in A2780 cells and HUVECs[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Stattic (10 mg/kg; i.p.; three times per week for 10 week) ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Age-matched wild-type (WT) C57BL/6 mice[3]
    Dosage: 10 mg/kg
    Administration: IP; three timesper week for 10 week
    Result: Increased levels of proteinuria, BUN and serum creatinine.
    Significantly suppressed the gene expression levels of renal injury markers (Lcn2, Kim-1), pro-inflammatory cytokines (Il-6, KC), pro-fibrotic genes (Tgf-β, Col1a1, α-Sma) and Mmp9.
    Molecular Weight

    211.19

    Formula

    C₈H₅NO₄S

    CAS No.

    19983-44-9

    SMILES

    O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (236.75 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.7351 mL 23.6754 mL 47.3507 mL
    5 mM 0.9470 mL 4.7351 mL 9.4701 mL
    10 mM 0.4735 mL 2.3675 mL 4.7351 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: ≥98.0%

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    Keywords:

    StatticSTATApoptosisp-STAT3Y705S727SH2AlportsyndromeP-ERK1/2PC3M-1E8prostatecancerS phaseInhibitorinhibitorinhibit

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