1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT


Cat. No.: HY-13818 Purity: >98.0%
Handling Instructions

Stattic is a potent inhibitor of STAT3, used for cancer treatment.

For research use only. We do not sell to patients.
Stattic Chemical Structure

Stattic Chemical Structure

CAS No. : 19983-44-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
25 mg USD 96 In-stock
50 mg USD 156 In-stock
100 mg USD 240 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    Stattic purchased from MCE. Usage Cited in: IUBMB Life. 2018 Jan;70(1):81-91.

    A549 cells are treated with TG101348 (3 nM), BMS-911543 (1.5 nM), and Stattic (2.5 lM) for 24 h, and the conditioned media are collected and applied for tube formation assay in HUVECs.

    Stattic purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Jan 18;9(2):25.

    Colony-formation assay of SW48 cells treated with CC-MSC-CM in the presence or absence of the STAT3 inhibitor (Stattic).
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References


    Stattic is a potent inhibitor of STAT3, used for cancer treatment.

    In Vitro

    Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 μM). Stattic selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+ and CD44+/CD24+ subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[2].

    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 4.7351 mL 23.6754 mL 47.3507 mL
    5 mM 0.9470 mL 4.7351 mL 9.4701 mL
    10 mM 0.4735 mL 2.3675 mL 4.7351 mL
    Please refer to the solubility information to select the appropriate solvent.
    Cell Assay

    Pancreatic cancer stem-like cells (3,000/well in 96-well plates) are incubated with desired concentrations of compounds in triplicate at 37˚C for 72 h. MTT viability assays are done and the absorbance is read at 595 nm. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight




    CAS No.




    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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