Cat. No.: HY-13818

Stattic

314 Cited Publications

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Based on 314 publication(s) in Google Scholar

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice.

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Pureté: 99.58%
CAS No.: 19983-44-9
Formule: C₈H₅NO₄S
Masse moléculaire:211.19

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Stattic Chemical Structure

CAS No.: 19983-44-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (314)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
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Activité biologique

Description

Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)^[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3^[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice^[3].

IC₅₀ & Target^[1]^[2]

STAT3

Voir tous les produits spécifiques à Isoform STAT :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.5 μM Compound: Stattic	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26396689]
A549	IC₅₀	4.4 μM Compound: Stattic	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 27718470]
ASPC1	IC₅₀	1.32 μM Compound: Stattic	Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
DU-145	IC₅₀	1.84 μM Compound: 2	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay	[PMID: 37594012]
DU-145	IC₅₀	2.5 μM Compound: Stattic	Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26396689]
HCT-116	IC₅₀	1.08 μM Compound: Stattic	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 27718470]
HCT-116	IC₅₀	2.16 μM Compound: Stattic	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31048139]
HEL	IC₅₀	1.59 μM Compound: Stattic	Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33689932]
HepG2	IC₅₀	3.52 μM Compound: Stattic	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31048139]
HepG2	IC₅₀	8.35 μM Compound: Cpd IV	Antitumor activity against human HepG2 cells measured after 48 hrs by MTT assay Antitumor activity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 37859719]
Huh-7	IC₅₀	7.89 μM Compound: Cpd IV	Antitumor activity against human Huh7 cells measured after 48 hrs by MTT assay Antitumor activity against human Huh7 cells measured after 48 hrs by MTT assay	[PMID: 37859719]
L02	IC₅₀	5.2 μM Compound: Stattic	Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31048139]
MCF-10A	IC₅₀	6.11 μM Compound: Stattic	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31048139]
MCF7	IC₅₀	1.7 μM Compound: Stattic	Antiproliferative activity against human MCF7 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33689932]
MCF7	IC₅₀	2.16 μM Compound: Stattic	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26396689]
MCF7	IC₅₀	2.36 μM Compound: Stattic	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 27718470]
MCF7	IC₅₀	3.6 μM Compound: Stattic	Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
MCF7	IC₅₀	3.71 μM Compound: Stattic	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31048139]
MDA-MB-231	IC₅₀	1.56 μM Compound: Stattic	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26396689]
MDA-MB-231	IC₅₀	1.66 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay	[PMID: 37594012]
MDA-MB-231	IC₅₀	1.68 μM Compound: Stattic	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 27718470]
MDA-MB-231	IC₅₀	1.81 μM Compound: Stattic	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31048139]
MDA-MB-231	IC₅₀	2.64 μM Compound: Stattic	Antiproliferative activity against human MDA-MB-231 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 32603980]
MDA-MB-231	IC₅₀	2.89 μM Compound: Stattic	Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
MDA-MB-435S	IC₅₀	1.87 μM Compound: Stattic	Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26396689]
MDA-MB-453	IC₅₀	4.4 μM Compound: Stattic	Antiproliferative activity against human MDA-MB-453 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-453 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33689932]
MDA-MB-468	IC₅₀	1.92 μM Compound: Stattic	Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay	[PMID: 32603980]
MDA-MB-468	IC₅₀	1.92 μM Compound: Stattic	Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33689932]
NIH3T3	IC₅₀	1.18 μM Compound: Stattic	Antiproliferative activity against mouse NIH3T3 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by CCK-8 assay Antiproliferative activity against mouse NIH3T3 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by CCK-8 assay	[PMID: 36463728]
PANC-1	IC₅₀	2.9 μM Compound: Stattic	Cytotoxicity against human PANC1 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human PANC1 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26396689]
PANC-1	IC₅₀	3.77 μM Compound: Stattic	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 24904966]
THLE-2	IC₅₀	>100 μM Compound: Cpd IV	Cytotoxicity against THLE-2 cells measured after 48 hrs by MTT assay Cytotoxicity against THLE-2 cells measured after 48 hrs by MTT assay	[PMID: 37859719]

In Vitro

Stattic (20 μM; 24 hours) inhibits STAT3 phosphorylation (Y705) and selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in ALDH⁺ and D44⁺/CD24⁺ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines^[1].
Stattic (2.5, 5, 10 μM; for 4 h) significantly reduces the nuclear level of pSTAT3 and survivin in PC3M-1E8 cells at 10 μM. Stattic (2.5-10 μM; for 24 h) inhibits IL-6-induced STAT3 activation in a dose-dependent manner^[2].
Stattic (2.5, 5, 10 μM; for 48 h) suppresses both the growth and induces apoptosis prostate cancer cells (PC3M-1E8 cells) with 10 μM. Stattic does not induce significant cell apoptosis with 2.5 μM, 5 μM^[2].
Stattic (2.5, 5, 10 μM; for 48 h) shows significant S phase accumulation^[2].
Stattic can not lead to significant morphological changes or apoptosis and has little STAT3 phosphorylation in A2780 cells and HUVECs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Stattic (10 mg/kg; i.p.; three times per week for 10 week) ameliorates the renal dysfunction in Alport syndrome (AS) mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Age-matched wild-type (WT) C57BL/6 mice^[3]
Dosage:

10 mg/kg
Administration:

IP; three timesper week for 10 week
Result:

Increased levels of proteinuria, BUN and serum creatinine.
Significantly suppressed the gene expression levels of renal injury markers (Lcn2, Kim-1), pro-inflammatory cytokines (Il-6, KC), pro-fibrotic genes (Tgf-β, Col1a1, α-Sma) and Mmp9.

Chemical Information

CAS No. 19983-44-9
Appearance Solid
Masse moléculaire 211.19
Formule C₈H₅NO₄S
Color Off-white to yellow
SMILES

O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (314)

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Mol Cancer

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis. [Abstract]

2019 Mar 30;18(1):64. PMID: 30927925

Stattic purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2019 Mar 30;18(1):64. [Abstract]

Western blot analysis of HCT116 cells alone, IL6-supplemented HCT116, TAMs-co-cultured HCT116 in the presence or absence of Stattic (15 μM).
Cell Metab

Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes. [Abstract]

2026 May 14:S1550-4131(26)00151-8. PMID: 42140185
Cell Metab

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. [Abstract]

2019 Jan 8;29(1):141-155.e9. PMID: 30174305
Immunity

An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment. [Abstract]

2026 Apr 27:S1074-7613(26)00141-X. PMID: 42049035
Nat Immunol

Secretogranin 2 binds LILRB4 resulting in immunosuppression. [Abstract]

2025 Sep;26(9):1567-1580. PMID: 40707822
Gut

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion. [Abstract]

2020 Jan;69(1):122-132. PMID: 31076405
Ann Rheum Dis

Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development. [Abstract]

2024 Aug 20:ard-2024-226067. PMID: 39164066

Stattic purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Stattic (2.5 µM; 48 h) significantly inhibits IL-9 (100 ng/mL; 48 h)-induced STAT3 phosphorylation and PU.1 expression in RA-Th9 cells.

Stattic purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Stattic (2.5 µM; 48 h) in Th9 cell supernatant significantly suppresses the migratory ability of RA-FLS.

Stattic purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Western blot analysis was performed to detect the IL-9 effect on the JAK1/STAT3 pathway in RA-Th9 cells. The cell treated with tofacitinib (10 μM, 48 h), stattic (2.5 μM, 48 h).

Stattic purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Flow cytometry was used to detect the JAK inhibitor tofacitinib (10 μM, 48 h) effect, STAT3 inhibitor statics (2.5 μM, 48 h), and PU.1 inhibitor DB2313 on the release of IL-9 from Th9 cells.

Stattic purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Flow cytometry was used to detect IL-9 and JAK inhibitor tofacitinib (10 μM, 48 h) effect, STAT3 inhibitor statics (2.5 μM, 48 h) effect on TNF-α-induced apoptosis in Th9 cells.

Stattic purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067. [Abstract]

Assess the effects of tofacitinib (10 μM, 48 h), stattics (2.5 μM, 48 h), and IL-9mAb on the cell migration of RA-FLS after treatment with the supernatant from RA-Th9 cells.
Cell Mol Immunol

IL-18 drives the Bhlhe40-mediated pathogenic Th17 cell response and exacerbates autoimmune disease progression. [Abstract]

2025 Oct 14. PMID: 41087718
Cell Host Microbe

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. [Abstract]

2026 Feb 11;34(2):245-262.e8. PMID: 41605216
Nat Cell Biol

Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer. [Abstract]

2026 Mar 13. PMID: 41826695
Cancer Res

Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells. [Abstract]

2024 Feb 1;84(3):479-492. PMID: 38095536
Drug Resist Updat

DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]

2025 Jul:81:101224. PMID: 40058099
Autophagy

High-fat diet exacerbates experimental colitis by inhibiting lysosomal function via the STAT3-TFEB Axis. [Abstract]

2026 May 28:1-24. PMID: 42165414
Nat Commun

Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice. [Abstract]

2026 Jun 5. PMID: 42248891
Nat Commun

Signaling cascades shape functional subpopulations of cortical astrocytes in male wild-type mice and APP/PS1dE9 Alzheimer's disease model. [Abstract]

2026 Apr 14;17(1):4194. PMID: 41980951
Nat Commun

Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow. [Abstract]

2025 Sep 25;16(1):8409. PMID: 40998791
Nat Commun

Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration. [Abstract]

2025 Mar 27;16(1):3012. PMID: 40148355
Nat Commun

Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway. [Abstract]

2025 Jan 3;16(1):289. PMID: 39753529
Nat Commun

IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. [Abstract]

2021 Jun 15;12(1):3651. PMID: 34131122
Exp Hematol Oncol

Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer with concomitant aberrant MET activation. [Abstract]

2024 Oct 1;13(1):97. PMID: 39354638
Exp Hematol Oncol

cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer. [Abstract]

2024 Jun 26;13(1):63. PMID: 38926796
J Adv Res

Peroxisome-derived and liver-specific hydroxyacid oxidase 1-mediated hydrogen peroxide promotes ferroptosis by augmenting peroxisomal ROS. [Abstract]

2026 Apr 15:S2090-1232(26)00342-5. PMID: 41990971
J Adv Res

Paracrine iron activates Hopx+ rectal cancer stem cells to display radioresistance. [Abstract]

2025 Nov 29:S2090-1232(25)00961-0. PMID: 41325838
J Adv Res

Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection. [Abstract]

2024 Feb:56:1-14. PMID: 36894120
J Adv Res

Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway. [Abstract]

2023 May:47:151-162. PMID: 35842187
Redox Biol

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux. [Abstract]

2025 Apr:81:103557. PMID: 39986118
Redox Biol

BNP protects against diabetic cardiomyopathy by promoting Opa1-mediated mitochondrial fusion via activating the PKG-STAT3 pathway. [Abstract]

2023 Jun:62:102702. PMID: 37116257
Redox Biol

Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy. [Abstract]

2021 Oct;46:102098. PMID: 34418601
Sci Transl Med

Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer. [Abstract]

2021 Oct 6;13(614):eabg6428. PMID: 34613810
J Nanobiotechnology

Exosome-shuttled miR-5121 from A2 astrocytes promotes BSCB repair after traumatic SCI by activating autophagy in vascular endothelial cells. [Abstract]

2025 Apr 15;23(1):291. PMID: 40229869
Theranostics

SPOP downregulation promotes bladder cancer progression based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is regulated by VEZF1. [Abstract]

2024 Oct 7;14(17):6543-6559. PMID: 39479456
Theranostics

Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models. [Abstract]

2023 Apr 23;13(8):2588-2604. PMID: 37215564
Theranostics

OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes. [Abstract]

2023 Apr 17;13(7):2263-2280. PMID: 37153745
Genes Dis

2026 Feb 14.
Acta Pharm Sin B

Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasis. [Abstract]

2025 Dec;15(12):6430-6443. PMID: 41477326
Acta Pharm Sin B

Macrophage DGK ζ-mediated phosphatidic acid remodeling aggravates acute liver failure. [Abstract]

2025 Aug;15(8):4078-4095. PMID: 40893681
Acta Pharm Sin B

STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation. [Abstract]

2025 Mar;15(3):1535-1551. PMID: 40370558
Acta Pharm Sin B

Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification. [Abstract]

2025 Jan;15(1):409-423. PMID: 40041920
J Exp Clin Cancer Res

Tumor suppressor SLC9A2 inhibits colorectal cancer metastasis and reverses immunotherapy resistance by suppressing angiogenesis. [Abstract]

2025 Jun 5;44(1):172. PMID: 40474298
J Exp Clin Cancer Res

Myeloid cell-derived apCAFs promote HNSCC progression by regulating proportion of CD4+ and CD8+ T cells. [Abstract]

2025 Jan 31;44(1):33. PMID: 39891284
J Exp Clin Cancer Res

CALB2 drives pancreatic cancer metastasis through inflammatory reprogramming of the tumor microenvironment. [Abstract]

2024 Oct 3;43(1):277. PMID: 39358777
J Exp Clin Cancer Res

Predicting response to immunotherapy in gastric cancer via assessing perineural invasion-mediated inflammation in tumor microenvironment. [Abstract]

2023 Aug 11;42(1):206. PMID: 37563649
J Clin Invest

IL20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. [Abstract]

2022 Oct 17;132(20):e157917. PMID: 36006737
J Exp Clin Cancer Res

Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion. [Abstract]

2021 Jan 4;40(1):4. PMID: 33390170
J Exp Clin Cancer Res

Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3η/NF-κB feedback loop. [Abstract]

2018 Dec 20;37(1):321. PMID: 30572915
J Exp Clin Cancer Res

17β-estradiol upregulates IL6 expression through the ERβ pathway to promote lung adenocarcinoma progression. [Abstract]

2018 Jul 3;37(1):133. PMID: 29970138
Adv Sci (Weinh)

Cholesterol-Mediated Metabolic-mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer. [Abstract]

2026 Jun 4:e75977. PMID: 42240967
Adv Sci (Weinh)

Single-Cell RNA-Sequencing Provides Insight into Skeletal Muscle Evolution during the Selection of Muscle Characteristics. [Abstract]

2023 Dec;10(35):e2305080. PMID: 37870215
Cell Rep Med

HE4 drives PD-L1 expression in myeloid cells via IFN-γR-JAK-STAT3 signaling to promote tumor immune evasion. [Abstract]

2026 Apr 21;7(4):102691. PMID: 41861828
Cell Rep Med

STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma. [Abstract]

2024 Mar 19;5(3):101472. PMID: 38508140
Sci Adv

Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3. [Abstract]

2025 Jun 27;11(26):eadu8422. PMID: 40561034
Sci Adv

Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. [Abstract]

2022 Feb 11;8(6):eabj1262. PMID: 35148178
Cell Death Differ

RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy. [Abstract]

2025 Nov 11. PMID: 41219491
Cell Death Differ

FMRP regulation of STAT3-MYC signaling is critical for adult hippocampal neurogenesis and cognitive flexibility. [Abstract]

2025 Jul 19. PMID: 40683950
Chem Eng J

2026 Apr 9;536:176067.
Cell Death Dis

Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction. [Abstract]

2026 May 19;17(1):632. PMID: 42156709
Cell Death Dis

Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription. [Abstract]

2026 Mar 27;17(1):364. PMID: 41896539
Cell Mol Biol Lett

CD209a regulates metabolic dysfunction-associated steatotic liver disease development through macrophage STAT3 signaling pathway. [Abstract]

2025 Nov 28;30(1):141. PMID: 41315908
Cell Death Dis

Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma. [Abstract]

2025 Feb 25;16(1):129. PMID: 40000620
Cell Death Dis

S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis. [Abstract]

2025 Jan 20;16(1):31. PMID: 39833165
Cell Death Dis

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity. [Abstract]

2024 Jun 19;15(6):430. PMID: 38898027
Cell Death Dis

N6-methyladenosine modification of REG1α facilitates colorectal cancer progression via β-catenin/MYC/LDHA axis mediated glycolytic reprogramming. [Abstract]

2023 Aug 25;14(8):557. PMID: 37626036
Pharmacol Res

Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease. [Abstract]

2022 Jun;180:106227. PMID: 35452800
Cell Death Dis

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma. [Abstract]

2022 May 25;13(5):496. PMID: 35614034
Cell Death Dis

The downregulation of type I IFN signaling in G-MDSCs under tumor conditions promotes their development towards an immunosuppressive phenotype. [Abstract]

2022 Jan 10;13(1):36. PMID: 35013108
Cell Death Dis

Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway. [Abstract]

2021 Sep 28;12(10):886. PMID: 34584074
Cell Death Dis

Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. [Abstract]

2021 Oct 5;12(10):910. PMID: 34611143
Cell Death Dis

CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma. [Abstract]

2019 Oct 14;10(10):781. PMID: 31611552
Pharmacol Res

Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways. [Abstract]

2019 Sep:147:104307. PMID: 31181334
Cell Death Dis

Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. [Abstract]

2018 Jan 18;9(2):25. PMID: 29348540
Cancer Lett

Targeting STAT3 potentiates CDK4/6 inhibitors therapy in head and neck squamous cell carcinoma. [Abstract]

2024 May 10:216956. PMID: 38735381
Cancer Lett

Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma. [Abstract]

2021 Oct 10:518:35-48. PMID: 34139285
Int J Biol Sci

BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer. [Abstract]

2023 Jan 1;19(2):465-483. PMID: 36632455
J Immunother Cancer

Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-α-induced apoptosis in tumor-repopulating cells of melanoma. [Abstract]

2020 Mar;8(1):e000111. PMID: 32152220
J Immunother Cancer

Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2-IL-6 cascade. [Abstract]

2019 Jul 12;7(1):178. PMID: 31300052
J Immunother Cancer

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1. [Abstract]

2018 Dec 18;6(1):151. PMID: 30563569
Cell Commun Signal

T cell receptor associated transmembrane adaptor 1 (TRAT1) modulates human Th17 and Treg responses via PI3-kinase and STAT dependent mechanisms. [Abstract]

2025 Oct 10;23(1):431. PMID: 41074026
Cell Commun Signal

Activation of kappa opioid receptor suppresses post-traumatic osteoarthritis via sequestering STAT3 on the plasma membrane. [Abstract]

2024 Jun 18;22(1):335. PMID: 38890746
Cell Commun Signal

Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis. [Abstract]

2024 Jun 6;22(1):313. PMID: 38844957
J Neuroinflammation

IFN-γ signaling links ventriculomegaly to choroid plexus and ependyma dysfunction following maternal immune activation. [Abstract]

2025 Mar 15;22(1):83. PMID: 40089736
J Neuroinflammation

Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model. [Abstract]

2024 Sep 16;21(1):227. PMID: 39285282
J Neuroinflammation

Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis. [Abstract]

2022 Feb 18;19(1):52. PMID: 35180864
Phytomedicine

Hyperoside accelerates myelin debris clearance by inhibiting signal transducer and activator of transcription 3 phosphorylation in peripheral nerve injury. [Abstract]

2026 Jul:156:158214. PMID: 42025010
Phytomedicine

Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling. [Abstract]

2026 Jul:156:158244. PMID: 42068880
Phytomedicine

Micheliolide directly targets keratinocyte Annexin A2 to abrogate STAT3-driven inflammation and pruritus in atopic dermatitis. [Abstract]

2026 May 15:157:158303. PMID: 42172985
Phytomedicine

Celastrol disrupts the inflammatory feedback loop driven by Tenascin-C⁺ fibroblast subtype in psoriasis: Insights from single-cell RNA sequencing and experimental validation. [Abstract]

2026 Apr:153:157988. PMID: 41763138
Phytomedicine

Baicalin and ginsenoside Rb1 suppress the activation of cardiac fibroblasts via regulating the GRK2/AT1R/MasR network. [Abstract]

2025 Oct 4:148:157371. PMID: 41110355
Phytomedicine

Shexiang baoxin pill ameliorates cardiac fibrosis by inhibiting fibroblast to myofibroblast transition through STAT3 phosphorylation suppression. [Abstract]

2025 Sep 15:148:157263. PMID: 40975042
Phytomedicine

Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis. [Abstract]

2024 Dec:135:156095. PMID: 39383632
Phytomedicine

Ophiopogonin D alleviates acute lung injury by regulating inflammation via the STAT3/A20/ASK1 axis. [Abstract]

2024 Jul 25:130:155482. PMID: 38824823
Phytomedicine

Ailanthone inhibits non-small cell lung cancer growth and metastasis through targeting UPF1/GAS5/ULK1 signaling pathway. [Abstract]

2024 Jun:128:155333. PMID: 38518633
Phytomedicine

Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway. [Abstract]

2022 Oct:105:154385. PMID: 35987015
Phytomedicine

Protective effect and mechanism of loganin and morroniside on acute lung injury and pulmonary fibrosis. [Abstract]

2022 May:99:154030. PMID: 35279615
Phytomedicine

Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells. [Abstract]

2020 Apr;69:153194. PMID: 32146299
Cell Death Discov

GAS6/AXL signaling promotes M2 microglia efferocytosis to alleviate neuroinflammation in sepsis-associated encephalopathy. [Abstract]

2025 Jun 6;11(1):268. PMID: 40480981
Cell Death Discov

CXCL12 alone is enough to Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts. [Abstract]

2025 Apr 8;11(1):156. PMID: 40199862
Acta Pharmacol Sin

Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer. [Abstract]

2025 Jan;46(1):184-195. PMID: 39198663
Cell Death Discov

NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC. [Abstract]

2024 Apr 1;10(1):159. PMID: 38561330
NPJ Precis Oncol

SPOCK1 acts as a negative regulator of ferroptosis in non-small cell lung cancer. [Abstract]

2026 May 14. PMID: 42135411
NPJ Precis Oncol

Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis. [Abstract]

2025 May 16;9(1):143. PMID: 40379975
J Transl Med

Targeting C5AR1 disrupts complement-driven G0-phase maintenance and overcomes metabolic drug resistance in glioma. [Abstract]

2026 May 22. PMID: 42174621
J Transl Med

ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction. [Abstract]

2025 Feb 24;23(1):224. PMID: 39994656
J Transl Med

Role of chemokine-mediated angiogenesis in resistance towards crizotinib and its reversal by anlotinib in EML4-ALK positive NSCLC. [Abstract]

2022 May 31;20(1):248. PMID: 35642002
Osteoarthritis Cartilage

CRLF1/CLCF1 heterodimer involvement in intervertebral disc degeneration via exacerbation of extracellular matrix degradation and nucleus pulposus cell senescence. [Abstract]

2025 May;33(5):574-589. PMID: 39986601
Oncogene

Ezh2Y641F mutations co-operate with Stat3 to regulate MHC class I antigen processing and alter the tumor immune response in melanoma. [Abstract]

2022 Nov;41(46):4983-4993. PMID: 36220978
Oncogene

NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation. [Abstract]

2022 Feb;41(6):907-919. PMID: 34992218
Int J Biol Macromol

Carpaine alleviates NASH-related fibrosis by targeting Nid1 to inhibit IL-6/JAK/STAT3 signaling and macrophage M1 polarization. [Abstract]

2025 Dec 3;337(Pt 1):149451. PMID: 41349744
JHEP Rep

PLOD1 promotes the malignancy of hepatocellular carcinoma by facilitating the NF-κB/IL-6/STAT3-dependent TCA cycle. [Abstract]

2025 Jan 20;7(5):101329. PMID: 40290518
Int J Biol Macromol

Targeting of KOR by famotidine promotes OPC maturation differentiation and CNS remyelination via STAT3 signaling pathway. [Abstract]

2024 Jun;269(Pt 2):131964. PMID: 38692525
Int J Nanomedicine

Chitosan-Coated-PLGA Nanoparticles Enhance the Antitumor and Antimigration Activity of Stattic - A STAT3 Dimerization Blocker. [Abstract]

2022 Jan 11;17:137-150. PMID: 35046650
Neural Regen Res

Downregulation of PDCD4 contributes to microglial efferocytosis and neurological function recovery following intracerebral hemorrhage. [Abstract]

2026 Apr 14. PMID: 41975620
Mol Ther Oncolytics

Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition. [Abstract]

2022 Jun 25;26:175-188. PMID: 35860007
Cell Mol Gastroenterol Hepatol

Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. [Abstract]

2019;7(2):255-274. PMID: 30686779
Am J Transplant

The NLRP3 inflammasome regulates corneal allograft rejection through enhanced phosphorylation of STAT3. [Abstract]

2020 Dec;20(12):3354-3366. PMID: 32583615
Free Radic Biol Med

IL-6/STAT3 signaling drives mitochondrial oxidative phosphorylation dysfunction and AP-1 activation in fibroblasts during sepsis-induced lung injury. [Abstract]

2026 May 26:253:148-163. PMID: 42191040
Free Radic Biol Med

Novel therapeutic approach for psoriasis: Upregulating FcRn to inhibit ferroptosis and alleviate lesional skin. [Abstract]

2024 Sep 11:S0891-5849(24)00657-9. PMID: 39270944
Free Radic Biol Med

IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. [Abstract]

2023 Aug 20:205:163-174. PMID: 37307935
Free Radic Biol Med

STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice. [Abstract]

2023 May 20:201:111-125. PMID: 36940731
Clin Transl Med

DCLK1-dependent NF-κB activation mediates p-STAT3-induced osteoarthritis progression. [Abstract]

2026 Jun;16(6):e70712. PMID: 42298903
Clin Transl Med

Tumour-derived SAA1 reprogrammes macrophages to promote CXCL1-mediated metastasis in Ovarian Cancer. [Abstract]

2026 May;16(5):e70698. PMID: 42145073
Stem Cell Res Ther

Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression. [Abstract]

2025 May 5;16(1):227. PMID: 40325465
Stem Cell Res Ther

MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy. [Abstract]

2025 Feb 4;16(1):40. PMID: 39901236
Stem Cell Res Ther

Targeting NPM1 inhibits proliferation and promotes apoptosis of hepatic progenitor cells via suppression of mTOR signalling pathway. [Abstract]

2024 Sep 11;15(1):292. PMID: 39256792
Br J Cancer

Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells. [Abstract]

2021 Jul;125(1):101-111. PMID: 33772151
Cell Rep

VEGFR2 inhibition potentiates STING-mediated antitumor immunity. [Abstract]

2026 Jun 18;45(7):117576. PMID: 42313565
Cell Rep

Trans-presentation of IL-6Rα by macrophages drives colorectal cancer development. [Abstract]

2026 Jun 19;45(7):117549. PMID: 42319827
Cell Rep

Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3. [Abstract]

2024 Dec 13;43(12):115057. PMID: 39675006
Aging Cell

Upregulation of the Cav1.3 channel in inner hair cells by interleukin 6-dependent inflammaging contributes to age-related hearing loss. [Abstract]

2024 Aug 15:e14305. PMID: 39148148
Cell Prolif

PFKFB4 facilitates palbociclib resistance in oestrogen receptor-positive breast cancer by enhancing stemness. [Abstract]

2023 Jan;56(1):e13337. PMID: 36127291
Mater Today Nano

9 November 2021, 100155.
J Ginseng Res

Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway. [Abstract]

2024 Jul;48(4):405-416. PMID: 39036731
Br J Pharmacol

Enhanced responsiveness of platelets to vicagrel in IL-10-deficient mice through STAT3-dependent up-regulation of the hydrolase arylacetamide deacetylase in the intestine. [Abstract]

2019 Jun;176(11):1717-1727. PMID: 30825385
Int J Oncol

Smoking promotes colorectal cancer via the CKAP2L/AREG axis. [Abstract]

2026 May;68(5):59. PMID: 41823522
Int J Oncol

High‑throughput screening identification of a small‑molecule compound that induces ferroptosis and attenuates the invasion and migration of hepatocellular carcinoma cells by targeting the STAT3/GPX4 axis. [Abstract]

2023 Mar;62(3):42. PMID: 36825585
Environ Pollut

Aquatic high iron induces hepatic ferroptosis in zebrafish (Danio rerio) via interleukin-22 signaling pathway. [Abstract]

2025 Jan 1:125627. PMID: 39746632
Cancer Cell Int

PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-POLG axis. [Abstract]

2023 Dec 16;23(1):323. PMID: 38102641
Cancer Cell Int

A novel STAT3/ NFκB p50 axis regulates stromal-KDM2A to promote M2 macrophage-mediated chemoresistance in breast cancer. [Abstract]

2023 Oct 11;23(1):237. PMID: 37821959
Cancer Cell Int

SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma. [Abstract]

2022 Jan 15;22(1):24. PMID: 35033067
Redox Rep

Macrophage metabolic reprogramming via HIF-1α-glycolysis drives osteoblast ferroptosis and bone loss through an IL-6-STAT3-dependent redox axis. [Abstract]

2026 Dec 31;31(1):2667673. PMID: 42071169
Cell Rep Phys Sci

2026 May 20.
J Ethnopharmacol

Direct targeting of STAT3 by xanthatin suppresses allergic airway inflammation via inhibition of TSLP release and NK2 cell polarization. [Abstract]

2026 May 10:362:121296. PMID: 41621761
J Ethnopharmacol

Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration. [Abstract]

2026 Apr 24:361:121268. PMID: 41611183
J Ethnopharmacol

Integrated serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of yiqitongmai decoction (YQTMD) against myocardial infarction. [Abstract]

2024 May 13:118329. PMID: 38750989
J Ethnopharmacol

Rosmarinic acid alleviates toosendanin-induced liver injury through restoration of autophagic flux and lysosomal function by activating JAK2/STAT3/CTSC pathway. [Abstract]

2024 Aug 10:330:118196. PMID: 38631488
J Agric Food Chem

Molecular Mechanism of Glycation Structure-Mediated Immune Recognition and Sensitization by Typical Milk Allergens. [Abstract]

2025 Aug 27;73(34):21566-21577. PMID: 40801482
CNS Neurosci Ther

Hypoxia Upregulates RIPK1 via the HIF-1α-JAK-STAT Pathway Leading to Astrocyte Necroptosis to Promote Cavitation After Spinal Cord Injury. [Abstract]

2026 May;32(5):e70895. PMID: 42109032
Ecotoxicol Environ Saf

Exposure to short-chain chlorinated paraffins induces astrocyte activation via JAK2/STAT3 signaling pathway. [Abstract]

2022 Dec 15:248:114268. PMID: 36375367

Stattic purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Dec 15:248:114268. [Abstract]

Stattic (10 μM) effectively attenuates the SCCP-mediated increase in iNOS and GFAP expression in C6 cells.
Biochem Pharmacol

Celastrol synergizes with MEK1 inhibitor nedometinib to overcome resistance in bladder cancer via dual suppression of CDK1/CDC5L and feedback-activated Akt/STAT3. [Abstract]

2025 Dec 10:245:117629. PMID: 41386559
Cell Mol Life Sci

Rab26 promotes hypoxia-induced hyperproliferation of PASMCs by modulating the AT1R-STAT3-YAP axis. [Abstract]

2025 Nov 13;82(1):396. PMID: 41231254
Biochem Pharmacol

RORγt agonist LYC-55716 potentiates IFN-α's efficacy in hepatocellular carcinoma through enhancing cytotoxicity of Tc17 cells and infiltration of CD8+ T cells. [Abstract]

2025 Apr 29:116963. PMID: 40312017
Cell Mol Life Sci

Inhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity. [Abstract]

2025 Feb 22;82(1):85. PMID: 39985685
Mol Ther Nucleic Acids

Intestinal epithelial cell autophagy deficiency suppresses inflammation-associated colon tumorigenesis. [Abstract]

2022 Feb 20:28:35-46. PMID: 35317201
Mech Ageing Dev

AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop. [Abstract]

2020 Oct;191:111347. PMID: 32882228
Life Sci

Glucocorticoid reduces mortality in LPS-induced sepsis mouse model by inhibiting JAK1/STAT3-mediated inflammatory response and restoring tricarboxylic acid cycle. [Abstract]

2025 May 21:375:123744. PMID: 40408938
Life Sci

Hinokiflavone exerts dual regulation on apoptosis and pyroptosis via the SIX4/Stat3/Akt pathway to alleviate APAP-induced liver injury. [Abstract]

2024 Aug 13:122968. PMID: 39147316
Food Biosci

2025 Jun.
J Mol Cell Biol

CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway. [Abstract]

2023 Aug 3;15(4):mjad025. PMID: 37073091
EMBO Rep

Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. [Abstract]

2023 Jan 9;24(1):e54729. PMID: 36341527
Commun Biol

cPLA2α inhibition potentiates anti-PD-1 immunotherapy in lung adenocarcinoma via remodeling tumor microenvironment. [Abstract]

2026 Jun 6. PMID: 42251144
J Inflamm (Lond)

RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch. [Abstract]

2025 Jun 11;22(1):21. PMID: 40500712
Commun Biol

Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling. [Abstract]

2022 Dec 1;5(1):1316. PMID: 36456628
Mol Cancer Res

Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism. [Abstract]

2021 Sep;19(9):1534-1545. PMID: 34172534
Nutrients

Three Polymethoxyflavones Purified from Ougan ( Citrus reticulata Cv. Suavissima) Inhibited LPS-Induced NO Elevation in the Neuroglia BV-2 Cell Line via the JAK2/STAT3 Pathway. [Abstract]

2019 Apr 5;11(4):791. PMID: 30959824
Mol Cancer Res

Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis. [Abstract]

2019 Jun;17(6):1378-1390. PMID: 30858172
Eur J Pharmacol

Carnosol inhibits influenza A virus by disrupting the viral envelope and interfering with Jak2/STAT3 signaling pathway. [Abstract]

2025 Apr 9:177606. PMID: 40216182
Respir Res

Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma. [Abstract]

2023 Oct 28;24(1):260. PMID: 37898756
Cancer Biol Ther

Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer. [Abstract]

2023 Dec 31;24(1):2226418. PMID: 37381162
Cell Biol Toxicol

NSD1 promotes esophageal cancer tumorigenesis via HIF1α signaling. [Abstract]

2023 Aug;39(4):1835-1850. PMID: 36522543
J Integr Agric

10 May 2022.
Int Immunopharmacol

Brain-derived HMGB1 mediates periodontal inflammation after ischemic stroke through the STAT3/NLRP3 inflammasome pathway. [Abstract]

2026 Sep 1:184:116962. PMID: 42242135
Int Immunopharmacol

Lactate-mediated Ran lactylation at lysine 123 promotes astrocytes polarization after oxygen-glucose deprivation/reoxygenation. [Abstract]

2026 Jan 1;168(Pt 2):115861. PMID: 41275824
Int Immunopharmacol

The JAK1/STAT3 pathway mediates the effects of SERPINH1 on glioma EMT. [Abstract]

2025 May 6:157:114731. PMID: 40334628
Int Immunopharmacol

TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3. [Abstract]

2025 May 26:159:114947. PMID: 40424660
Int Immunopharmacol

Aerosol inhalation of rhIL-10 improves acute lung injury in mice by affecting pulmonary neutrophil phenotypes through neutrophil-platelet aggregates. [Abstract]

2025 Jan 6:147:113948. PMID: 39778276
Int Immunopharmacol

Liraglutide alleviates ferroptosis in renal ischemia reperfusion injury via inhibiting macrophage extracellular trap formation. [Abstract]

2024 Sep 27;142(Pt B):113258. PMID: 39340991
Int J Mol Sci

STAT3 Increases CVB3 Replication and Acute Pancreatitis and Myocarditis Pathology via Impeding Nuclear Translocation of STAT1 and Interferon-Stimulated Gene Expression. [Abstract]

2024 Aug 19;25(16):9007. PMID: 39201692
Int J Mol Sci

Threonine Deficiency Increases Triglyceride Deposition in Primary Duck Hepatocytes by Reducing STAT3 Phosphorylation. [Abstract]

2024 Jul 26;25(15):8142. PMID: 39125712
Biomolecules

Human Menstrual Blood-Derived Stem Cells Protect against Tacrolimus-Induced Islet Dysfunction via Cystathionine β-Synthase Mediated IL-6/STAT3 Inactivation. [Abstract]

2024 Jun 8;14(6):671. PMID: 38927074
Int Immunopharmacol

IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway. [Abstract]

2024 Jan 25:127:111367. PMID: 38160564
Int Immunopharmacol

Long noncoding RNA MCM3AP-AS1 attenuates sepsis-induced cardiomyopathy by improving inflammation, oxidative stress, and mitochondrial function through mediating the miR-501-3p/CADM1/STAT3 axis. [Abstract]

2024 Feb 15:128:111500. PMID: 38237222
Int Immunopharmacol

STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage. [Abstract]

2023 Oct:123:110709. PMID: 37515849
Int J Mol Sci

Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells. [Abstract]

2023 Apr 13;24(8):7219. PMID: 37108378
Int Immunopharmacol

ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus. [Abstract]

2023 Jun:119:110216. PMID: 37116342
Int Immunopharmacol

miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation. [Abstract]

2021 Jul:96:107587. PMID: 33819732
Int Immunopharmacol

Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway. [Abstract]

2020 Apr;81:106240. PMID: 32044657
Invest Ophthalmol Vis Sci

Epac1 Inhibits Orbital Fibroblast Activation to Ameliorate Thyroid-Associated Orbitopathy-Like Features Through the JAK/STAT Signaling Pathway. [Abstract]

2025 Jul 1;66(9):68. PMID: 40736178
Bone Joint Res

Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function. [Abstract]

2024 Apr 4;13(4):157-168. PMID: 38569602
Am J Respir Cell Mol Biol

Pathogenic Rewiring of IL6 Signaling Fuels Macrophage Immunometabolic reprogramming in COPD. [Abstract]

2026 Jun 23:aanag113. PMID: 42334931
Am J Physiol Cell Physiol

OTUD6A in tubular epithelial cells mediates Angiotensin II-induced kidney injury by targeting STAT3. [Abstract]

2024 Feb 1;326(2):C400-C413. PMID: 38105755
Inflammation

LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages. [Abstract]

2024 Feb;47(1):307-322. PMID: 37782452
Front Pharmacol

Strongylocentrotus nudus Eggs Polysaccharide Enhances Macrophage Phagocytosis Against E.coli Infection by TLR4/STAT3 Axis. [Abstract]

2022 Mar 17;13:807440. PMID: 35370674
Toxicology

Co-exposure to polystyrene nanoplastics and cadmium induces apoptosis in intestinal cells: Role of the IP3R/Ca²⁺/STAT3 signaling pathway. [Abstract]

2026 Jun:523:154449. PMID: 41833704
J Drug Deliv Sci Technol

2020 Jul.
Eur J Pharm Sci

Development and in vitro/in vivo evaluation of polymeric dissolving microneedle formulation for psoriasis treatment. [Abstract]

2026 Mar 1:218:107429. PMID: 41506586
Biochim Biophys Acta Mol Basis Dis

Neddylation of STAT3 is a potential therapeutic target for MASLD. [Abstract]

2026 Apr 15;1872(6):168261. PMID: 41990488
J Mol Med (Berl)

BMSCs-derived exosomal AKAP12 alleviates neuronal cell ferroptosis by inhibiting the STAT3 and ERK signaling pathways in spinal cord injury. [Abstract]

2025 Oct 15. PMID: 41094204
Mol Med Rep

Stattic suppresses p‑STAT3 and induces cell death in T‑cell acute lymphoblastic leukemia. [Abstract]

2025 Feb;31(2):51. PMID: 39670305
Biochim Biophys Acta Mol Basis Dis

Involvement of PD-1+CD4+ T cells in the development of traumatic tracheal stenosis by regulating the IL-17/STAT3 pathway. [Abstract]

2024 Aug;1870(6):167216. PMID: 38718843
Mol Med Rep

STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells. [Abstract]

2023 Apr;27(4):81. PMID: 36825563

Stattic purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2023 Apr;27(4):81. [Abstract]

Stattic (5, 15, 30 µM; 4 h) markedly inhibits Y705 STAT3 phosphorylation in both senescent TC‑1 (Fig. C) and TRAMP‑C2 (Fig. D) cells in a concentration‑dependent manner.
PLoS Pathog

Glutamine alleviates Staphylococcus aureus-induced mastitis by modulating macrophage polarisation. [Abstract]

2026 Mar 11;22(3):e1014053. PMID: 41811877
Mediators Inflamm

LncRNA NEAT1 Knockdown Alleviates Macrophage Ferroptosis and Atherosclerosis by Suppressing STAT3 Activation. [Abstract]

2025 Nov 12:2025:8862449. PMID: 41268533
Sci Rep

IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma. [Abstract]

2025 Sep 29;15(1):33534. PMID: 41022893
Sci Rep

Mitochondrial-dependent apoptosis and STAT3 activation induced by oxidative stress in pemphigus vulgaris. [Abstract]

2025 Aug 14;15(1):29900. PMID: 40813461
Sci Rep

SLC10A3 regulates ferroptosis of glioblastoma through the STAT3/GPX4 pathway. [Abstract]

2025 Jul 1;15(1):21259. PMID: 40596220
Sci Rep

Molybdenum facilitates PDLSC-based bone regeneration through the JAK/STAT3 signaling pathway. [Abstract]

2025 Jul 1;15(1):22204. PMID: 40594624
World J Stem Cells

Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. [Abstract]

2024 Nov 26;16(11):906-925. PMID: 39619875
Cancers (Basel)

LncRNA HAR1A Suppresses the Development of Non-Small Cell Lung Cancer by Inactivating the STAT3 Pathway. [Abstract]

2022 Jun 8;14(12):2845. PMID: 35740511
Cell Signal

Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling. [Abstract]

2025 May 17:111877. PMID: 40389045
Cell Signal

ANXA2 promotes chondrocyte differentiation and fracture healing by regulating the phosphorylation of STAT3 and PI3K/AKT signaling pathways. [Abstract]

2025 Jan 23:127:111617. PMID: 39863030
Neuropharmacology

PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation. [Abstract]

2023 Sep 1:235:109571. PMID: 37146940
Cell Signal

STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes. [Abstract]

2023 Aug:108:110717. PMID: 37187216
J Cell Mol Med

Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4. [Abstract]

2022 Apr;26(8):2363-2376. PMID: 35224833
Cell Signal

NCAPD3 promotes prostate cancer progression by up-regulating EZH2 and MALAT1 through STAT3 and E2F1. [Abstract]

2022 Apr:92:110265. PMID: 35085770
J Mol Biol

Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling. [Abstract]

2020 Sep 1;12(9):723-737. PMID: 32242230
Oncol Rep

JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal type. [Abstract]

2019 Jun;41(6):3219-3232. PMID: 31002364
J Cell Mol Med

Long non-coding RNA MALAT1 regulates angiogenesis following oxygen-glucose deprivation/reoxygenation. [Abstract]

2019 Apr;23(4):2970-2983. PMID: 30784209
Cell Signal

Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation. [Abstract]

2019 Mar:55:65-72. PMID: 30610893

Stattic purchased from MedChemExpress. Usage Cited in: Cell Signal. 2019 Mar:55:65-72. [Abstract]

Western blotting and densitometric analysis of p-STAT3 in Lo2 cells after 24 h of treatment with the indicated concentrations of the STAT3 inhibitor stattic.
Oncol Res

SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]

2026 Jan 19;34(2):25. PMID: 41613800
J Inflamm Res

SMP30 Attenuates Lens Epithelial Cells Pyroptosis of Cataract via the Downregulation of p-STAT3. [Abstract]

2025 Sep 8:18:12361-12377. PMID: 40951443
Oncol Res

IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation. [Abstract]

2024 Mar 20;32(4):625-641. PMID: 38560562
J Inflamm Res

Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway. [Abstract]

2022 May 31:15:3187-3205. PMID: 35668915
iScience

Integrative multiomics analysis identifies RARRES2 as a regulator of keloid pathogenesis through STAT3/HSPG2 signaling axis. [Abstract]

2026 Apr 20;29(5):115797. PMID: 42170108
Clin Exp Med

Bioinformatics and experimental approaches identify NME8 as a promoter of the metastasis of renal cell carcinoma by activating the JAK/STAT signaling pathway. [Abstract]

2026 Jan 2;26(1):68. PMID: 41483244
iScience

PBRM1 presents a potential ctDNA marker to monitor response to neoadjuvant chemotherapy in cervical cancer. [Abstract]

2024 Feb 9;27(3):109160. PMID: 38414861
Biomedicines

KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT Pathway. [Abstract]

2023 Dec 1;11(12):3194. PMID: 38137415
FASEB J

Brown adipose tissue-derived exosomes improve polycystic ovary syndrome in mice via STAT3/GPX4 signaling pathway. [Abstract]

2024 Sep 30;38(18):e70062. PMID: 39305125
Antiviral Res

Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response. [Abstract]

2023 Sep:217:105676. PMID: 37481038
Front Physiol

Endoplasmic Reticulum Stress/Ca2+-Calmodulin-Dependent Protein Kinase/Signal Transducer and Activator of Transcription 3 Pathway Plays a Role in the Regulation of Cellular Zinc Deficiency in Myocardial Ischemia/Reperfusion Injury. [Abstract]

2022 Jan 5:12:736920. PMID: 35069232
Front Physiol

High Glucose Activated Cardiac Fibroblasts by a Disruption of Mitochondria-Associated Membranes. [Abstract]

2021 Aug 18;12:724470. PMID: 34483973
J Biol Chem

ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia. [Abstract]

2024 Jun 27:107499. PMID: 38944125
Naunyn Schmiedebergs Arch Pharmacol

Integrated multi-omics and experimental validation for identifying novel biomarkers of acute myocardial infarction. [Abstract]

2026 Jun;399(9):14067-14089. PMID: 41949600
Naunyn Schmiedebergs Arch Pharmacol

Corynoline promotes apoptosis and inhibits proliferation of glioblastoma via regulating the STAT3/Bcl-2 signalling pathway. [Abstract]

2025 Dec 11. PMID: 41379317
ACS Pharmacol Transl Sci

Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf. [Abstract]

2023 Dec 5;7(1):176-185. PMID: 38230274
J Funct Foods

2025 Apr.
Am J Physiol Heart Circ Physiol

Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart. [Abstract]

2022 Jul 1;323(1):H103-H120. PMID: 35594067
Vet Res

Th17 cells/IL-17A shape Pasteurella multocida serotype A infection in murine and rabbit models. [Abstract]

2025 Dec 16;56(1):229. PMID: 41402924
Viruses

2026 Jan 1.
Metab Brain Dis

Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression. [Abstract]

2025 Jul 1;40(6):238. PMID: 40591076
Vet Res

Binding of Trichinella spiralis C-type lectin with syndecan-1 on intestinal epithelial cells mediates larval invasion of intestinal epithelium. [Abstract]

2023 Oct 2;54(1):86. PMID: 37784173
Mol Immunol

Cigarette smoke-exposed microparticles released from T lymphocytes contribute to autophagy and apoptosis dysfunction in pulmonary microvascular endothelial cells. [Abstract]

2025 May:181:9-17. PMID: 40048930
Vascul Pharmacol

Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension. [Abstract]

2023 Dec:153:107233. PMID: 37742818
J Bioenerg Biomembr

Blockage of PHLPP1 protects against myocardial ischemia/reperfusion injury in diabetic mice via activation of STAT3 signaling. [Abstract]

2023 Oct;55(5):325-339. PMID: 37584737
Parasit Vectors

B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway. [Abstract]

2022 May 3;15(1):157. PMID: 35505420
Toxicol Appl Pharmacol

Corynoxine suppresses hepatocellular carcinoma progression by forming the ROS-STAT3 cycle. [Abstract]

2026 Jun 16:514:117917. PMID: 42303055
Cytokine

Qinling liquid ameliorates renal immune inflammatory damage via activating autophagy through AMPK/Stat3 pathway in uric acid nephropathy. [Abstract]

2023 Mar:163:156120. PMID: 36630870
Biochim Biophys Acta Gene Regul Mech

m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling. [Abstract]

2019 Aug;1862(8):796-806. PMID: 31295563
Cell Biol Int

Karyopherin Subunit Alpha 3 Drives Temozolomide Resistance in Glioblastoma by Upregulating MGMT and Activating STAT3 to Sustain Glioma Stem Cells. [Abstract]

2026 Jun;50(6):e70175. PMID: 42295990
Int J Biochem Cell Biol

Bemcentinib enhances sensitivity to estrogen receptor inhibitors in breast cancer cells. [Abstract]

2025 Feb 1:180:106750. PMID: 39900236
Arch Biochem Biophys

The LINC00319 binding to STAT3 promotes the cell proliferation, migration, invasion and EMT process in oral squamous cell carcinoma. [Abstract]

2024 Nov:761:110170. PMID: 39366629
Mol Carcinog

The cumulative antitumor effects of regorafenib and radiotherapy in hepatocellular carcinoma. [Abstract]

2024 Sep;63(9):1738-1749. PMID: 38837427
Exp Cell Res

Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression. [Abstract]

2023 Mar 22;426(2):113565. PMID: 36958650
Mol Carcinog

CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis. [Abstract]

2017 Nov;56(11):2434-2445. PMID: 28618089

Stattic purchased from MedChemExpress. Usage Cited in: Mol Carcinog. 2017 Nov;56(11):2434-2445. [Abstract]

Cells are treated with the STAT3 inhibitor Stattic. The inhibitory action of Stattic on STAT3 phosphorylation is confirmed by Western blot.
Brain Sci

Minocycline Ameliorates Staphylococcus aureus-Induced Neuroinflammation and Anxiety-like Behaviors by Regulating the TLR2 and STAT3 Pathways in Microglia. [Abstract]

2025 Jan 28;15(2):128. PMID: 40002461
J Cancer

STAT3 inhibitor Stattic Exhibits the Synergistic Effect with FGFRs Inhibitor Erdafitinib in FGFR1-positive Lung Squamous Cell Carcinoma. [Abstract]

2024 Aug 19;15(16):5415-5424. PMID: 39247610
Front Oncol

Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway. [Abstract]

2021 Nov 22;11:762523. PMID: 34881181
J Cancer

Upregulation of V-ATPase by STAT3 Activation Promotes Anoikis Resistance and Tumor Metastasis. [Abstract]

2021 Jun 11;12(16):4819-4829. PMID: 34234852
J Cancer

Activated STAT3 Could Reduce Survival in Patients with Esophageal Squamous Cell Carcinoma by Up-regulating VEGF and Cyclin D1 Expression. [Abstract]

2020 Jan 20;11(7):1859-1868. PMID: 32194797
Immunol Lett

Lenvatinib-resistant liver cancer-derived HSP90α-containing extracellular vesicles enhance drug resistance via macrophage CXCL8 secretion. [Abstract]

2026 Apr:278:107122. PMID: 41349809
IUBMB Life

MicroRNA-204 deregulation in lung adenocarcinoma controls the biological behaviors of endothelial cells potentially by modulating Janus kinase 2-signal transducer and activator of transcription 3 pathway. [Abstract]

2018 Jan;70(1):81-91. PMID: 29281186

Stattic purchased from MedChemExpress. Usage Cited in: IUBMB Life. 2018 Jan;70(1):81-91. [Abstract]

A549 cells are treated with TG101348 (3 nM), BMS-911543 (1.5 nM), and Stattic (2.5 lM) for 24 h, and the conditioned media are collected and applied for tube formation assay in HUVECs.
Toxicol Lett

Comparative transcriptomic analysis reveals STAT3 as a candidate gene involved in aristolochic acid I-induced hepatorenal toxicity. [Abstract]

2025 Dec 30:416:111811. PMID: 41478365
Med Microbiol Immunol

Furamidine enhances IL-23-mediated autophagic response through IL-23R-TYK2-STAT3-dependent regulation of intracellular Ca²⁺ level to facilitate mycobacterial clearance in human macrophages. [Abstract]

2025 Nov 14;214(1):50. PMID: 41236630
Tissue Cell

Fusobacterium nucleatum promotes bladder cancer progression and immune escape by activating the IL22/STAT3/PD-L1 signaling cascade. [Abstract]

2025 Jul 29:97:103065. PMID: 40795596
Immunobiology

Ureaplasma urealyticum GrpE protein elicits glycolysis-mediated inflammatory responses through TLR2 in macrophages. [Abstract]

2025 Apr 21;230(3):152902. PMID: 40273504
Toxicol Lett

Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis. [Abstract]

2024 Apr:394:102-113. PMID: 38460807
Immunobiology

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation. [Abstract]

2022 Jan;227(1):152165. PMID: 34936966
Theriogenology

LncRNA STAT3-AS regulates endometrial receptivity via the STAT3 signaling pathway. [Abstract]

2024 Mar 1:216:118-126. PMID: 38171198
Vet Microbiol

ASFV activates STAT3 to induce proviral M2 macrophage polarization. [Abstract]

2025 Dec:311:110733. PMID: 41106189
Discov Oncol

Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia. [Abstract]

2025 May 12;16(1):739. PMID: 40353923
Discov Oncol

Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets. [Abstract]

2025 Apr 29;16(1):637. PMID: 40299210
Int J Immunopathol Pharmacol

Low-dose metformin suppresses hepatocellular carcinoma metastasis via the AMPK/JNK/IL-8 pathway. [Abstract]

2024 Jan-Dec:38:3946320241249445. PMID: 38679570
Int J Hyperthermia

Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells. [Abstract]

2024 Feb 13;41(1):2310017. PMID: 38350654
Gene

LncRNA GAS5 regulates apoptosis in ovarian cancer cells by regulating O-GlcNAcylation of GOLGA8B. [Abstract]

2026 May 15:991:150084. PMID: 41791436
Immunol Res

Immunomodulatory activity of 4-(Benzyloxy)phenol facilitates intracellular mycobacterial clearance through p53 mediated IL-35 signaling dependent JAK1/STAT3 pathway in human macrophages. [Abstract]

2025 Jun 26;73(1):99. PMID: 40571857
Immunol Res

Metformin suppresses gammadelta T17 cell differentiation alleviating DSS-induced colitis. [Abstract]

2025 Feb 11;73(1):49. PMID: 39934569
Odontology

Transcriptional regulation of human follicular dendritic cell-secreted protein gene by interleukin-6. [Abstract]

2025 Jul;113(3):1081-1091. PMID: 39776305
Eur J Haematol

Interferon gamma regulates a complex pro-survival signal network in chronic lymphocytic leukemia. [Abstract]

2023 Apr;110(4):435-443. PMID: 36576398
DNA Cell Biol

JMJD3 Promotes Porphyromonas gingivalis Lipopolysaccharide-Induced Th17-Cell Differentiation by Modulating the STAT3-RORc Signaling Pathway. [Abstract]

2022 Aug;41(8):778-787. PMID: 35867069
Cancer Manag Res

Normal Basal Epithelial Cells Stimulate the Migration and Invasion of Prostate Cancer Cell RM-1 by TGF-β1/STAT3 Axis in vitro. [Abstract]

2021 May 7:13:3685-3697. PMID: 33994809
Biochem Biophys Res Commun

Increased hepcidin in hemorrhagic plaques correlates with iron-stimulated IL-6/STAT3 pathway activation in macrophages. [Abstract]

2019 Jul 23;515(2):394-400. PMID: 31153641
FASEB Bioadv

NCAPD3-mediated AKT activation regulates prostate cancer progression. [Abstract]

2025 Jan 7;7(2):e1488. PMID: 39917394
Dev Comp Immunol

IL-21 signaling promotes IgM+ B cell proliferation and antibody production via JAK/STAT3 and AKT pathways in early vertebrates. [Abstract]

2025 Jan 25:105325. PMID: 39870186
J Chin Med Assoc

ReDuNing inhibits alveolar macrophage inflammation in LPS mice by activating JAK1/STAT3. [Abstract]

2025 Jul 22. PMID: 40693722
J Oral Biosci

Proinflammatory effects of factor Xa on human dental pulp cells. [Abstract]

2025 Dec;67(4):100707. PMID: 41274690
Exp Ther Med

IL-22/IL-22R1 promotes proliferation and collagen synthesis of MRC-5 cells via the JAK/STAT3 signaling pathway and regulates airway subepithelial fibrosis. [Abstract]

2020 Sep;20(3):2148-2156. PMID: 32765690
Exp Ther Med

Crocin has pharmacological effects against the pathological behavior of colon cancer cells by interacting with the STAT3 signaling pathway. [Abstract]

2020 Feb;19(2):1297-1303. PMID: 32010302
Leuk Lymphoma

IFN-γ enhances CLL cell resistance to ABT-199 by regulating MCL-1 and BCL-2 expression via the JAK-STAT3 signaling pathway. [Abstract]

2023 Jan;64(1):71-78. PMID: 36222521
In Vitro Cell Dev Biol Anim

Lactiplantibacillus plantarum promotes lactoferrin synthesis and secretion in bovine mammary epithelial cells through STAT3 and AP-1 transcription factor pathways. [Abstract]

2025 Aug;61(7):886-897. PMID: 40802133
Curr Med Sci

Crosstalk Between Th17 Cells and Renal Tubular Epithelial Cells Promotes Fibrotic Progression in IgA Nephropathy. [Abstract]

2025 Jun;45(3):626-639. PMID: 40498423
Int J Rheum Dis

JAK2 inhibitors improve RA combined with pulmonary fibrosis in rats by downregulating SMAD3 phosphorylation. [Abstract]

2024 May;27(5):e15164. PMID: 38706209
Turk J Haematol

The IRF2-INPP4B pathway is activated in CD4+ T cells and aggravates acute myeloid leukemia development by inhibiting apoptosis. [Abstract]

2025 May 22;42(2):82-91. PMID: 39960210
Brain Inj

Progranulin alleviates cerebral ischemia-reperfusion-induced neuronal ferroptosis via regulating p-STAT3/HSPA5 signaling. [Abstract]

2026 May;40(7):619-630. PMID: 41961642
SSRN

2026 Jun 21.
SSRN

2025 Oct 21.
bioRxiv

2025 Oct 27.
Biomed Pharmacother

IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis. [Abstract]

2025 Apr 16:187:118054. PMID: 40245547
bioRxiv

2025 January 31.
Res Sq

2024 Jun 27.
Res Sq

2024 Jun 05.
SSRN

2024 Apr 3.
SSRN

2024 Feb 13.
Research Square Preprint

2023 Nov 1.
Research Square Preprint

2023 Oct 11.
SSRN

3 Nov 2022.
Oxid Med Cell Longev

IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo. [Abstract]

2022 May 10;2022:9635075. PMID: 35592531
Biomed Pharmacother

Activation of α7nAChR preserves intestinal barrier integrity by enhancing the HO-1 / STAT3 signaling to inhibit NF-κB activation in mice. [Abstract]

2022 May:149:112733. PMID: 36068769
Comput Intell Neurosci

RAGE Regulating Vascular Remodeling in Diabetes by Regulating Mitochondrial Dynamics with JAK2/STAT3 Pathway. [Abstract]

2022 Apr 22;2022:2685648. PMID: 35498181
Int J Biol Sci

Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop. [Abstract]

2022 Jan 16;18(4):1363-1380. PMID: 35280694
Research Square Preprint

2021 Nov.
Research Square Preprint

2021 Aug.
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 Jul.
Ann Transl Med

Lower androgen levels promote abnormal cartilage development in female patients with adolescent idiopathic scoliosis. [Abstract]

2021 May;9(9):784. PMID: 34268397
Research Square Preprint

2020 Dec.
Research Square Preprint

2020 Sep.

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (236.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7351 mL

23.6754 mL

47.3507 mL

5 mM

0.9470 mL

4.7351 mL

9.4701 mL

10 mM

0.4735 mL

2.3675 mL

4.7351 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 1.67 mg/mL (7.91 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (394 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
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MS (2659 KB)
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IR (2659 KB)
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OR (2659 KB)
SDS-PAGE (2659 KB)
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Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12. [Content Brief]

[2]. John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13(11):1123-4. [Content Brief]

[3]. Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33(2):214-223. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7351 mL	23.6754 mL	47.3507 mL	118.3768 mL
	5 mM	0.9470 mL	4.7351 mL	9.4701 mL	23.6754 mL
	10 mM	0.4735 mL	2.3675 mL	4.7351 mL	11.8377 mL
	15 mM	0.3157 mL	1.5784 mL	3.1567 mL	7.8918 mL
	20 mM	0.2368 mL	1.1838 mL	2.3675 mL	5.9188 mL
	25 mM	0.1894 mL	0.9470 mL	1.8940 mL	4.7351 mL
	30 mM	0.1578 mL	0.7892 mL	1.5784 mL	3.9459 mL
	40 mM	0.1184 mL	0.5919 mL	1.1838 mL	2.9594 mL
	50 mM	0.0947 mL	0.4735 mL	0.9470 mL	2.3675 mL
	60 mM	0.0789 mL	0.3946 mL	0.7892 mL	1.9729 mL
	80 mM	0.0592 mL	0.2959 mL	0.5919 mL	1.4797 mL
	100 mM	0.0474 mL	0.2368 mL	0.4735 mL	1.1838 mL

Keywords

Stattic

314 Cited Publications

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Stattic

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Cysteine Targeted Covalent Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Posttranslational Modification Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Stattic

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Chemical Information

Publications (314)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Stattic Related Classifications

HY-13818 Related Classifications