1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

Stattic 

Cat. No.: HY-13818 Purity: >98.0%
Handling Instructions

Stattic is a potent inhibitor of STAT3 activation and dimerization.

For research use only. We do not sell to patients.

Stattic Chemical Structure

Stattic Chemical Structure

CAS No. : 19983-44-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
25 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 156 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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Customer Review

    Stattic purchased from MCE. Usage Cited in: Mol Carcinog. 2017 Nov;56(11):2434-2445.

    Cells are treated with the STAT3 inhibitor Stattic. The inhibitory action of Stattic on STAT3 phosphorylation is confirmed by Western blot.

    Stattic purchased from MCE. Usage Cited in: IUBMB Life. 2018 Jan;70(1):81-91.

    A549 cells are treated with TG101348 (3 nM), BMS-911543 (1.5 nM), and Stattic (2.5 lM) for 24 h, and the conditioned media are collected and applied for tube formation assay in HUVECs.

    Stattic purchased from MCE. Usage Cited in: Cell Signal. 2019 Mar;55:65-72.

    Western blotting and densitometric analysis of p-STAT3 in Lo2 cells after 24 h of treatment with the indicated concentrations of the STAT3 inhibitor stattic.

    View All STAT Isoform Specific Products:

    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Stattic is a potent inhibitor of STAT3 activation and dimerization.

    In Vitro

    Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 μM). Stattic selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+ and CD44+/CD24+ subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[2].

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (236.75 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.7351 mL 23.6754 mL 47.3507 mL
    5 mM 0.9470 mL 4.7351 mL 9.4701 mL
    10 mM 0.4735 mL 2.3675 mL 4.7351 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

    References
    Cell Assay
    [1]

    Pancreatic cancer stem-like cells (3,000/well in 96-well plates) are incubated with desired concentrations of compounds in triplicate at 37˚C for 72 h. MTT viability assays are done and the absorbance is read at 595 nm.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    211.19

    Formula

    C₈H₅NO₄S

    CAS No.

    19983-44-9

    SMILES

    O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Stattic
    Cat. No.:
    HY-13818
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    Stattic

    Cat. No.: HY-13818