1. JAK/STAT Signaling
    Stem Cell/Wnt
    Neuronal Signaling
  2. STAT
    Amyloid-β

Colivelin 

Cat. No.: HY-P1061
Handling Instructions

Colivelin is a neuroprotective peptide and activator of STAT3. Sequence: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro;SALLRSIPAPAGASRLLLLTGEIDLP.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Colivelin Chemical Structure

Colivelin Chemical Structure

CAS No. : 867021-83-8

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Description

Colivelin is a neuroprotective peptide and activator of STAT3. Sequence: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro;SALLRSIPAPAGASRLLLLTGEIDLP.

IC50 & Target

STAT3

 

Amyloid-β

 

In Vitro

Colivelin is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative[2]. Humanin (HN) and its derivatives, such as Colivelin (CLN), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3[1]. Colivelin completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM[2].

In Vivo

Humanin (HN) and its derivatives, such as Colivelin (CLN) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ) [1]. Intracerebroventricular administration of Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[2].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3781 mL 1.8903 mL 3.7806 mL
5 mM 0.0756 mL 0.3781 mL 0.7561 mL
10 mM 0.0378 mL 0.1890 mL 0.3781 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Prepared PCNs (5.0×104 cells per well in a 96-well plate) are preincubated with or without synthetic Colivelin (100 aM, 1 fM, 10 fM, 100 fM, 1 pM, 10 pM, 100 pM, 1 nM, 10 nM, or 100 nM) or AGA-(C8R)HNG17 for 16 h and treated with 25 μM Aβ1-43 or 20 μM l-glutamate in the presence or absence of the factors for 72 h. Cell viability assays are performed with calcein AM and water-soluble tetrazolium salt[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Mice[2]

8-week-old CD-1 mice are implanted with cannulas in the left lateral ventricle of brain . Ten days after cannula implantation, animals are assigned randomly to the control group, the Aβ-injection group, or the Aβ plus Colivelin-injection group, receiving intracerebroventricular injection of 3 μL of sterile deionized distilled water (ddw), 300 pmol of Aβ1-42, or 1 nmol of Aβ25-35 peptide in 3 μL of ddw, every other day for 3 weeks together with injection of 3 μL of sterile saline or 10 pmol of Colivelin in 3 μL of sterile saline once every 6 d. Behavioral tests are performed from 2 d after the last intracerebroventricular injection[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2645.10

Formula

C₁₁₉H₂₀₆N₃₂O₃₅

CAS No.

867021-83-8

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Colivelin
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Colivelin

Cat. No.: HY-P1061