1. JAK/STAT Signaling
    Stem Cell/Wnt
    Neuronal Signaling
  2. STAT


Cat. No.: HY-P1061
Handling Instructions

Colivelin is a neuroprotective peptide and activator of STAT3.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Colivelin Chemical Structure

Colivelin Chemical Structure

CAS No. : 867021-83-8

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  • Biological Activity

  • Protocol

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Colivelin is a neuroprotective peptide and activator of STAT3.

IC50 & Target





In Vitro

Colivelin is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative[2]. Humanin (HN) and its derivatives, such as Colivelin (CLN), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3[1]. Colivelin completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM[2].

In Vivo

Humanin (HN) and its derivatives, such as Colivelin (CLN) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ) [1]. Intracerebroventricular administration of Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[2].

Cell Assay

Prepared PCNs (5.0×104 cells per well in a 96-well plate) are preincubated with or without synthetic Colivelin (100 aM, 1 fM, 10 fM, 100 fM, 1 pM, 10 pM, 100 pM, 1 nM, 10 nM, or 100 nM) or AGA-(C8R)HNG17 for 16 h and treated with 25 μM Aβ1-43 or 20 μM l-glutamate in the presence or absence of the factors for 72 h. Cell viability assays are performed with calcein AM and water-soluble tetrazolium salt[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration


8-week-old CD-1 mice are implanted with cannulas in the left lateral ventricle of brain . Ten days after cannula implantation, animals are assigned randomly to the control group, the Aβ-injection group, or the Aβ plus Colivelin-injection group, receiving intracerebroventricular injection of 3 μL of sterile deionized distilled water (ddw), 300 pmol of Aβ1-42, or 1 nmol of Aβ25-35 peptide in 3 μL of ddw, every other day for 3 weeks together with injection of 3 μL of sterile saline or 10 pmol of Colivelin in 3 μL of sterile saline once every 6 d. Behavioral tests are performed from 2 d after the last intracerebroventricular injection[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Sequence Shortening



Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-P1061