1. JAK/STAT Signaling
    Stem Cell/Wnt
    Neuronal Signaling
  2. STAT
    Amyloid-β
  3. Colivelin

Colivelin 

Cat. No.: HY-P1061
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Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

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Colivelin Chemical Structure

Colivelin Chemical Structure

CAS No. : 867021-83-8

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Top Publications Citing Use of Products

    Colivelin purchased from MCE. Usage Cited in: Aging (Albany NY). 2020 May 15;12.

    The protein expression of the biomarkers of JAK-STAT signaling pathway. The expression of TNF-α, IFN-β, IL-6 and MCP-1 is all upregulated and IL-4 expression are downregulated in the group treated with miR-142-5p versus the NC group, and it could be rescued by Colivelin.

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    Description

    Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro[1]. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease[2]. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury[1]

    IC50 & Target[1]

    STAT3

     

    Amyloid-β

     

    In Vitro

    Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm, and keep its neuroprotective action at or above the levels of 1 nm[1].
    Colivelin-induced neuroprotection occurs via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN[1].
    Colivelin reverses caspase3, Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition[4].
    Colivelin (50 µg/mL, 4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells[4].

    Western Blot Analysis[4]

    Cell Line: BV-2 cells.
    Concentration: 50 µg/mL.
    Incubation Time: 4 hours.
    Result: Increased p-STAT3 levels.

    Cell Viability Assay[5]

    Cell Line: KYSE70 and TE8 cells.
    Concentration: 0.5 μM.
    Incubation Time: 1 hour (followed by CYT-Rx20 treatment)
    Result: Sgnificantly suppressed the viability in KYSE70 and TE8 cells.
    In Vivo

    Colivelin (intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[1].
    Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21 mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit[1].
    Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO[3].

    Animal Model: CD-1 mice[1]
    Dosage: 10 pmol/3 μl
    Administration: Intracerebroventricular administration
    Result: Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
    Animal Model: C57 mice[1]
    Dosage: 1.4, 7, or 35 nM/0.21mL
    Administration: Intraperitoneal administration
    Result: Protected against cholinotoxin-induced amnesia in mice.
    Animal Model: Male C57BL/6 mice[3]
    Dosage: 1 mg/kg
    Administration: Intraperitoneal administration
    Result: Protected against ischemic brain injury, and improves neurological outcomes
    Molecular Weight

    2645.10

    Formula

    C₁₁₉H₂₀₆N₃₂O₃₅

    CAS No.

    867021-83-8

    Sequence

    Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro

    Sequence Shortening

    SALLRSIPAPAGASRLLLLTGEIDLP

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    ColivelinSTATAmyloid-ββ-amyloid peptideAbetaischemicbraininjuryneurologicalalzheimerdiseaseNeuroprotectantInhibitorinhibitorinhibit

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