2. JAK/STAT Signaling Stem Cell/Wnt Neuronal Signaling Apoptosis
  3. STAT Amyloid-β Apoptosis
  4. Colivelin TFA

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Colivelin TFA Chemical Structure

Colivelin TFA Chemical Structure

CAS No. : 2803948-60-7

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500 μg USD 190 In-stock
1 mg USD 290 In-stock
5 mg USD 870 In-stock
10 mg USD 1390 In-stock
25 mg USD 2780 In-stock
50 mg USD 4300 In-stock
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Based on 35 publication(s) in Google Scholar

Other Forms of Colivelin TFA:

Colivelin TFA Related Antibodies

Top Publications Citing Use of Products

34 Publications Citing Use of MCE Colivelin TFA

WB

    Colivelin TFA purchased from MedChemExpress. Usage Cited in: Aging. 2020 May 15;12(10):9066-9084.  [Abstract]

    The protein expression of the biomarkers of JAK-STAT signaling pathway. The expression of TNF-α, IFN-β, IL-6 and MCP-1 is all upregulated and IL-4 expression are downregulated in the group treated with miR-142-5p versus the NC group, and it could be rescued by Colivelin.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro[1]. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease[2]. Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury[1].

    IC50 & Target[1]

    STAT3

     

    Amyloid-β

     

    In Vitro

    Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Aβ1-43 at a concentration of 100 fm, and keep its neuroprotective action at or above the levels of 1 nm[1].
    Colivelin-induced neuroprotection occurs via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN[1].
    Colivelin reverses caspase3, Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition[4].
    Colivelin (50 µg/mL, 4 hours) significantly increases the p-STAT3 protein levels in BV-2 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Colivelin TFA Related Antibodies

    Western Blot Analysis[4]

    Cell Line: BV-2 cells.
    Concentration: 50 µg/mL.
    Incubation Time: 4 hours.
    Result: Increased p-STAT3 levels.

    Cell Viability Assay[5]

    Cell Line: KYSE70 and TE8 cells.
    Concentration: 0.5 μM.
    Incubation Time: 1 hour (followed by CYT-Rx20 treatment)
    Result: Significantly suppressed the viability in KYSE70 and TE8 cells.
    In Vivo

    Colivelin(intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[1].
    Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit[1].
    Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: CD-1 mice[1]
    Dosage: 10 pmol/3 μl
    Administration: Intracerebroventricular administration
    Result: Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
    Animal Model: C57 mice[1]
    Dosage: 1.4, 7, or 35 nM/0.21mL
    Administration: Intraperitoneal administration
    Result: Protected against cholinotoxin-induced amnesia in mice.
    Animal Model: Male C57BL/6 mice[3]
    Dosage: 1 mg/kg
    Administration: Intraperitoneal administration
    Result: Protected against ischemic brain injury, and improves neurological outcomes.
    Molecular Weight

    2759.12

    Formula

    C119H206N32O35.C2HF3O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence Shortening

    SALLRSIPAPAGASRLLLLTGEIDLP
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (18.12 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.3624 mL 1.8122 mL 3.6243 mL
    5 mM 0.0725 mL 0.3624 mL 0.7249 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    V1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  Water with 5% sefsol and 20% isopropanol

      Solubility: 6.25 mg/mL (2.27 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.52%

    COA (240 KB) LCMS (92 KB) Elemental Analysis Report (100 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.3624 mL 1.8122 mL 3.6243 mL 9.0609 mL
    5 mM 0.0725 mL 0.3624 mL 0.7249 mL 1.8122 mL
    10 mM 0.0362 mL 0.1812 mL 0.3624 mL 0.9061 mL
    15 mM 0.0242 mL 0.1208 mL 0.2416 mL 0.6041 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Colivelin TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Colivelin2803948-60-7STATAmyloid-βApoptosisβ-amyloid peptideAβAbetaischemicbraininjuryneurologicalalzheimerdiseaseNeuroprotectantInhibitorinhibitorinhibit

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