1. JAK/STAT Signaling
    Stem Cell/Wnt
    Neuronal Signaling
  2. STAT
    Amyloid-β

Colivelin TFA 

Cat. No.: HY-P1061A Purity: 95.29%
Handling Instructions

Colivelin (TFA) is a neuroprotective peptide and activator of STAT3.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Colivelin TFA Chemical Structure

Colivelin TFA Chemical Structure

Size Price Stock Quantity
500 μg USD 190 In-stock
Estimated Time of Arrival: December 31
1 mg USD 290 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Other Forms of Colivelin TFA:

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Colivelin (TFA) is a neuroprotective peptide and activator of STAT3.

IC50 & Target[1]

STAT3

 

Amyloid-β

 

In Vitro

Colivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative[2]. Humanin (HN) and its derivatives, such as Colivelin (TFA), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3[1]. Colivelin (TFA) completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM[2].

In Vivo

Humanin (HN) and its derivatives, such as Colivelin (TFA) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ)[1]. Intracerebroventricular administration of Colivelin (TFA) not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[2].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3624 mL 1.8122 mL 3.6243 mL
5 mM 0.0725 mL 0.3624 mL 0.7249 mL
10 mM 0.0362 mL 0.1812 mL 0.3624 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

2759.12

Formula

C₁₁₉H₂₀₆N₃₂O₃₅.C₂HF₃O₂

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Colivelin TFA
Cat. No.:
HY-P1061A
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Colivelin TFA

Cat. No.: HY-P1061A