1. JAK/STAT Signaling
    Stem Cell/Wnt
    Neuronal Signaling
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  3. Colivelin TFA

Colivelin TFA 

Cat. No.: HY-P1061A Purity: 95.29%
Handling Instructions

Colivelin (TFA) is a neuroprotective peptide and activator of STAT3.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Colivelin TFA Chemical Structure

Colivelin TFA Chemical Structure

Size Price Stock Quantity
500 μg USD 190 In-stock
Estimated Time of Arrival: December 31
1 mg USD 290 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Colivelin (TFA) is a neuroprotective peptide and activator of STAT3.

IC50 & Target





In Vitro

Colivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative[2]. Humanin (HN) and its derivatives, such as Colivelin (TFA), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3[1]. Colivelin (TFA) completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM[2].

In Vivo

Humanin (HN) and its derivatives, such as Colivelin (TFA) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ)[1]. Intracerebroventricular administration of Colivelin (TFA) not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[2].

Molecular Weight






Sequence Shortening



Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (9.06 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3624 mL 1.8122 mL 3.6243 mL
5 mM 0.0725 mL 0.3624 mL 0.7249 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
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ColivelinSTATAmyloid-ββ-amyloid peptideAbetaInhibitorinhibitorinhibit

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