1. JAK/STAT Signaling
    Stem Cell/Wnt
    Neuronal Signaling
  2. STAT
    Amyloid-β

Colivelin TFA 

Cat. No.: HY-P1061A Purity: 95.29%
Handling Instructions

Colivelin (TFA) is a neuroprotective peptide and activator of STAT3. Sequence: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro;SALLRSIPAPAGASRLLLLTGEIDLP.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Colivelin TFA Chemical Structure

Colivelin TFA Chemical Structure

Size Price Stock Quantity
500 μg USD 190 In-stock
Estimated Time of Arrival: December 31
1 mg USD 290 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Other Forms of Colivelin TFA:

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Colivelin (TFA) is a neuroprotective peptide and activator of STAT3. Sequence: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro;SALLRSIPAPAGASRLLLLTGEIDLP.

IC50 & Target[1]

STAT3

 

Amyloid-β

 

In Vitro

Colivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative[2]. Humanin (HN) and its derivatives, such as Colivelin (TFA), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3[1]. Colivelin (TFA) completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM[2].

In Vivo

Humanin (HN) and its derivatives, such as Colivelin (TFA) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ)[1]. Intracerebroventricular administration of Colivelin (TFA) not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[2].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3624 mL 1.8122 mL 3.6243 mL
5 mM 0.0725 mL 0.3624 mL 0.7249 mL
10 mM 0.0362 mL 0.1812 mL 0.3624 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

2759.12

Formula

C₁₁₉H₂₀₆N₃₂O₃₅.C₂HF₃O₂

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Colivelin TFA
Cat. No.:
HY-P1061A
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Colivelin TFA

Cat. No.: HY-P1061A