1123-54-2
1123-54-2
Chemical Structure
8-Azaadenine
- CAS No.: 1123-54-2
- Formula:C4H4N6
- Molecular Weight:136.12
IUPAC Name: 3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine
InChIKey: HRYKDUPGBWLLHO-UHFFFAOYSA-N
SMILES: NC1=C(N=NN2)C2=NC=N1
Biological Activity: 8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. 8-Azaadenine can be produced via the metabolism of 8-Azaadenosine (HY-115686) and incorporated into polynucleotide chains together with 8-Azaguanine (HY-B1468) to affect purine metabolism. 8-Azaadenine can be used in the study of cancer[1][2][3].
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8-Azaadenine | 99.85% | 8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. 8-Azaadenine can be produced via the metabolism of 8-Azaadenosine (HY-115686) and incorporated into polynucleotide chains together with 8-Azaguanine (HY-B1468) to affect purine metabolism. 8-Azaadenine can be used in the study of cancer. | ||||||||||||||||||||
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References
- [1]. Sheu SY, et al. Inhibition of xanthine oxidase by synthetic cytokinin analogues. Anticancer Res. 1997 Mar-Apr;17(2A):1043-9. [Content Brief]
- [2]. Holý A, et al Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. J Med Chem. 1996 Sep 27;39(20):4073-88. [Content Brief]
- [3]. Bennett LL Jr, et al. Metabolism and metabolic effects of 8-azainosine and 8-azaadenosine. Cancer Res. 1976 Nov;36(11 Pt 1):3917-23. [Content Brief]
Keywords
