2. GPCR/G Protein
  3. P2Y Receptor
  4. 8-Aminoadenine

8-Aminoadenine is an adenine receptor 1 (rAde1R) inhibitor with a Ki of 6.51 μM in rat and 0.0341 μM in human. 8-Aminoadenine inhibits isoprenaline-induced cAMP accumulation and adenine uptake in astrocytoma cells expressing rAde1R. 8-Aminoadenine serves as a lead structure for the development of adenine receptor ligands to elucidate the functions of the adenine receptor family.

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8-Aminoadenine

8-Aminoadenine Chemical Structure

CAS No. : 28128-33-8

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Based on 1 publication(s) in Google Scholar

8-Aminoadenine Related Antibodies

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Description

8-Aminoadenine is an adenine receptor 1 (rAde1R) inhibitor with a Ki of 6.51 μM in rat and 0.0341 μM in human. 8-Aminoadenine inhibits isoprenaline-induced cAMP accumulation and adenine uptake in astrocytoma cells expressing rAde1R. 8-Aminoadenine serves as a lead structure for the development of adenine receptor ligands to elucidate the functions of the adenine receptor family[1].

IC50 & Target

Ki：6.51 μM (adenine receptor)[1].
In Vitro

8-Aminoadenine (Compound 33) binds to rat cerebral cortex membrane preparations (rAde1R) with a Ki value of 6.51 μM[1].
8-Aminoadenine binds to HEK293 cell membrane preparations with a Ki value of 0.0341 μM[1].
8-Aminoadenine (500 μM; 10 min) inhibits isoprenaline (HY-B0468)-induced cAMP accumulation in 1321N1 astrocytoma cells[1].
8-Aminoadenine (100 μM; 1 min) potently inhibits [3H] adenine uptake in 1321N1 astrocytoma cells stably expressing rAde1R[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8-Aminoadenine Related Antibodies
Molecular Weight

150.14

Formula

C5H6N6
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

NC1=C2N=C(N)NC2=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1 M HCl : 0.5 mg/mL (3.33 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6604 mL 33.3022 mL 66.6045 mL
5 mM --- --- ---
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* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1 M HCl 1 mM 6.6605 mL 33.3023 mL 66.6045 mL 166.5113 mL
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8-Aminoadenine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Aminoadenine28128-33-8P2Y Receptorrat brain cortical membrane preparationsadenine receptor familyrAde1Rhuman embryonic kidney (HEK293) cell membrane preparations1321N1 astrocytoma cellshuman adenine binding siterat adenine receptor 1adenine receptor ligandsastrocytoma cellsInhibitorinhibitorinhibit

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