Xanthine oxidase-IN-4
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research.
For research use only. We do not sell to patients.
- CAS No.: 2642137-96-8
- Formula: C15H13N5O2
- Molecular Weight:295.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.039 μM (xanthine oxidase)[1]
Xanthine oxidase-IN-4 (compound 19a) (1 nM-10 μM, 15 min) exhibits a strong XO inhibitory potency, with an IC50 of 0.039 μM, and Ki of 0.0037 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (Six weeks, male, 180-200g, six groups)[1]
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Dosage:10 mg/kg
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Administration:Intragastrically, once
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Result:Significantly reduced the serum concentration of uric acid, with AUC (uric acid, 1-5 h) of 44.3%.
Chemical Information
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CAS No. 2642137-96-8
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Molecular Weight 295.30
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Formula C15H13N5O2
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SMILES
N#CC1=CC(C2=NC=C3C(NNC3=O)=N2)=CC=C1OC(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xanthine oxidase-IN-4 Related Classifications
HY-144303 Related Classifications
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