2642137-96-8
2642137-96-8
Chemical Structure
Xanthine oxidase-IN-4
- CAS No.: 2642137-96-8
- Formula:C15H13N5O2
- Molecular Weight:295.30
IUPAC Name: 2-isopropoxy-5-(3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)benzonitrile
InChIKey: LBJXVRNULAGYQQ-UHFFFAOYSA-N
SMILES: N#CC1=CC(C2=NC=C3C(NNC3=O)=N2)=CC=C1OC(C)C
Biological Activity: Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].
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Xanthine oxidase-IN-4 | Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research. | |||||||||||||||||||||
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References
- [1]. Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086. [Content Brief]
Keywords
