441785-24-6
441785-24-6
Chemical Structure
LB80317
- CAS No.: 441785-24-6
- Formula:C10H14N5O5P
- Molecular Weight:315.22
IUPAC Name: ((1-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphonic acid
InChIKey: IMAMTECZRBMXGW-UHFFFAOYSA-N
SMILES: OP(O)(COC1(CN2C=NC3=C2N=C(N)NC3=O)CC1)=O
Biological Activity: LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
LB80317 | LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC50 of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Man-Fung Yuen, et al. Pharmacokinetics of LB80331 and LB80317 Following Oral Administration of LB80380, a New Antiviral Agent for Chronic Hepatitis B (CHB), in Healthy Adult Subjects, CHB Patients, and Mice. Antimicrob Agents Chemother. 2009 May;53(5):177 [Content Brief]
- [2]. Lung-Yi Mak, et al. Pharmacokinetic Evaluation of Besifovir for the Treatment of HBV Infection. Expert Opin Drug Metab Toxicol. 2018 Jan;14(1):101-106. [Content Brief]
Keywords
