1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Pyridoxamine 5′-phosphate

Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate.

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Pyridoxamine 5′-phosphate Chemical Structure

Pyridoxamine 5′-phosphate Chemical Structure

CAS No. : 529-96-4

Size Price Stock Quantity
1 mg USD 469 In-stock
5 mg USD 1171 In-stock
10 mg USD 1874 In-stock
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Description

Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Pyridoxamine 5′-phosphate can be transformed from pyridoxal 5′-phosphate. Purified His-tagged omega-TA CV2025 from Chromobacterium violaceum is capable of complete conversion of pyridoxal 5′-phosphate to pyridoxamine 5′-phosphate in the presence of (S)-α-methylbenzylamine (MBA) as the amine donor.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.17

Formula

C8H13N2O5P

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=P(O)(OCC1=CN=C(C)C(O)=C1CN)O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (201.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0295 mL 20.1475 mL 40.2950 mL
5 mM 0.8059 mL 4.0295 mL 8.0590 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0295 mL 20.1475 mL 40.2950 mL 100.7374 mL
5 mM 0.8059 mL 4.0295 mL 8.0590 mL 20.1475 mL
10 mM 0.4029 mL 2.0147 mL 4.0295 mL 10.0737 mL
15 mM 0.2686 mL 1.3432 mL 2.6863 mL 6.7158 mL
20 mM 0.2015 mL 1.0074 mL 2.0147 mL 5.0369 mL
25 mM 0.1612 mL 0.8059 mL 1.6118 mL 4.0295 mL
30 mM 0.1343 mL 0.6716 mL 1.3432 mL 3.3579 mL
40 mM 0.1007 mL 0.5037 mL 1.0074 mL 2.5184 mL
50 mM 0.0806 mL 0.4029 mL 0.8059 mL 2.0147 mL
60 mM 0.0672 mL 0.3358 mL 0.6716 mL 1.6790 mL
80 mM 0.0504 mL 0.2518 mL 0.5037 mL 1.2592 mL
100 mM 0.0403 mL 0.2015 mL 0.4029 mL 1.0074 mL
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Pyridoxamine 5′-phosphate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pyridoxamine 5′-phosphate
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HY-B1746
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