1. GPCR/G Protein
    Others
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Estrogen Receptor/ERR
    LXR
  3. (20S)-Protopanaxatriol

(20S)-Protopanaxatriol (Synonyms: 20(S)-APPT; g-PPT)

Cat. No.: HY-N0835 Purity: >98.0%
Handling Instructions

(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.

For research use only. We do not sell to patients.

(20S)-Protopanaxatriol Chemical Structure

(20S)-Protopanaxatriol Chemical Structure

CAS No. : 34080-08-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 81 In-stock
Estimated Time of Arrival: December 31
5 mg USD 74 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 296 In-stock
Estimated Time of Arrival: December 31
100 mg USD 479 In-stock
Estimated Time of Arrival: December 31
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Description

(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor.

IC50 & Target

Glucocorticoid receptor, Oestrogen receptor[1], LXRα[2]

In Vitro

(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ[1]. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene[2].

Molecular Weight

476.73

Formula

C₃₀H₅₂O₄

CAS No.

34080-08-5

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (98.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0976 mL 10.4881 mL 20.9762 mL
5 mM 0.4195 mL 2.0976 mL 4.1952 mL
10 mM 0.2098 mL 1.0488 mL 2.0976 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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(20S)-Protopanaxatriol
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