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Signaling Pathway

2-Methoxyestradiol

HY-12033

(2-ME2; NSC-659853)

2-Methoxyestradiol

2-Methoxyestradiol Chemical Structure

2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.

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10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $110 In-stock
100 mg $200 In-stock
200 mg Get quote
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Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
10 mg €49 In-stock
50 mg €108 In-stock
100 mg €196 In-stock
200 mg Get quote
500 mg Get quote

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Product name: 2-Methoxyestradiol
Cat. No.: HY-12033

2-Methoxyestradiol Data Sheet

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    Purity: 98.66%

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Related Compound Libraries

Biological Activity of 2-Methoxyestradiol

2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.
IC50 value:0.71 uM
Target: HIF-1α
in vitro: 2-Methoxyestradiol exhibits the inhibitory activity of cellular proliferation in a breast carcinoma cell line MDA-MB-435 and an ovarian carcinoma cell line SK-OV-3 with IC50 of 1.38 μM and 1.79 μM, respectively. Furthermore, 2-Methoxyestradiol also inhibits cellular microtubule depolymerization in rat aortic smooth muscle A-10 cells with EC50 of 7.5 μM [1]. 2-Methoxyestradiol inhibits proliferation of MCF-7 and BM cells with IC50 of 52 μM and 8 μM [2]. A recent study shows that 2-Methoxyestradiol (0.5 μM), blocks TGF-β3-induced expression of collagen (Col) type I(αI), Col III(αI), plasminogen activator inhibitor (PAI) 1, connective tissue growth factor (CTGF), and α-smooth muscle actin (α-SMA). Moreover, 2-Methoxyestradiol ameliorates TGF-β3-induced Smad2/3 phosphorylation and nuclear translocation, and inhibits TGF-β3-induced activation of the PI3K/Akt/mTOR pathway [3].
in vivo: In a 9L rat glioma (9L-V6R) rat model, 2-Methoxyestradiol significantly decreases HIF-1 activity and inhibits the tumor growth in a dose-dependent manner by 4-fold reduction for 60 mg/kg/day, and 23-fold reduction for 600 mg/kg/day, respectively [4].

Chemical Information

M.Wt 302.41 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₁₉H₂₆O₃
CAS No 362-07-2
Solvent & Solubility

DMSO: ≥ 36 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.3068 mL 16.5338 mL 33.0677 mL
5 mM 0.6614 mL 3.3068 mL 6.6135 mL
10 mM 0.3307 mL 1.6534 mL 3.3068 mL

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