1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. CH-0793076 TFA

CH-0793076 TFA (Synonyms: TP3076 TFA)

Cat. No.: HY-107096B Purity: 98.26%
Handling Instructions

CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein).

For research use only. We do not sell to patients.

CH-0793076 TFA Chemical Structure

CH-0793076 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].

IC50 & Target[1]

Topoisomerase I

2.3 μM (IC50)

In Vitro

CH0793076 (TP3076) TFA (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

572.53

Formula

C₂₈H₂₇F₃N₄O₆

SMILES

O=C1[[email protected]](O)(CC)C(C=C23)=C(CO1)C(N2CC(C3=N4)=C5N(CCCCC)C=NC6=C5C4=CC=C6)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (116.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7466 mL 8.7332 mL 17.4663 mL
5 mM 0.3493 mL 1.7466 mL 3.4933 mL
10 mM 0.1747 mL 0.8733 mL 1.7466 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (8.73 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

CH-0793076TP3076CH0793076CH 0793076TP 3076TP-3076Topoisomerasebreastcancerresistancemetaboliteantiproliferativeanti-cancertoxicitycolorectalInhibitorinhibitorinhibit

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Product Name:
CH-0793076 TFA
Cat. No.:
HY-107096B
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