Demethylcantharidate disodium
Based on 1 Customer Validation
Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 129-67-9
- Formula: C8H8Na2O5
- Molecular Weight:230.13
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1].
Demethylcantharidate (0, 9, 18 or 36 μM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCC cell lines (SMMC-7721 and Bel-7402)
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Concentration:0-100 μM
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Incubation Time:0, 12, 24, 48 or 72 hours
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Result:Showed anti-proliferative activity in the two HCC cell lines.
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Cell Line:HCC cells
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Concentration:0, 9, 18 or 36 µM
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Incubation Time:24 hours
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Result:Induced apoptosis in HCC cells via the intrinsic pathway.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 129-67-9
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Appearance Solid
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Molecular Weight 230.13
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Formula C8H8Na2O5
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Color White to off-white
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SMILES
O=C(C1C(C2OC1CC2)C(O[Na])=O)O[Na]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 250 mg/mL (1086.34 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (217.27 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.3454 mL | 21.7268 mL | 43.4537 mL | 108.6342 mL |
| 5 mM | 0.8691 mL | 4.3454 mL | 8.6907 mL | 21.7268 mL | |
| 10 mM | 0.4345 mL | 2.1727 mL | 4.3454 mL | 10.8634 mL | |
| 15 mM | 0.2897 mL | 1.4485 mL | 2.8969 mL | 7.2423 mL | |
| 20 mM | 0.2173 mL | 1.0863 mL | 2.1727 mL | 5.4317 mL | |
| 25 mM | 0.1738 mL | 0.8691 mL | 1.7381 mL | 4.3454 mL | |
| 30 mM | 0.1448 mL | 0.7242 mL | 1.4485 mL | 3.6211 mL | |
| 40 mM | 0.1086 mL | 0.5432 mL | 1.0863 mL | 2.7159 mL | |
| 50 mM | 0.0869 mL | 0.4345 mL | 0.8691 mL | 2.1727 mL | |
| 60 mM | 0.0724 mL | 0.3621 mL | 0.7242 mL | 1.8106 mL | |
| 80 mM | 0.0543 mL | 0.2716 mL | 0.5432 mL | 1.3579 mL | |
| 100 mM | 0.0435 mL | 0.2173 mL | 0.4345 mL | 1.0863 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Demethylcantharidate disodium Related Classifications
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