1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Demethylcantharidate disodium

Demethylcantharidate disodium 

Cat. No.: HY-N1443
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Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer.

For research use only. We do not sell to patients.

Demethylcantharidate disodium Chemical Structure

Demethylcantharidate disodium Chemical Structure

CAS No. : 129-67-9

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1].

In Vitro

Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1].
Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCC cell lines (SMMC-7721 and Bel-7402)
Concentration: 0-100 μM
Incubation Time: 0, 12, 24, 48 or 72 hours
Result: Showed anti-proliferative activity in the two HCC cell lines.

Cell Viability Assay[1]

Cell Line: HCC cells
Concentration: 0, 9, 18 or 36 µM
Incubation Time: 24 hours
Result: Induced apoptosis in HCC cells via the intrinsic pathway.
In Vivo

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

230.13

Formula

C₈H₈Na₂O₅

CAS No.
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Storage

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Demethylcantharidate disodium
Cat. No.:
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