2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Endothall

Endothall  (Synonyms: Endothal)

Cat. No.: HY-113976A Purity: ≥95.0%
COA Handling Instructions

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Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy.

For research use only. We do not sell to patients.

Endothall Chemical Structure

Endothall Chemical Structure

CAS No. : 145-73-3

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Endothall Related Antibodies

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Description

Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy[1].

In Vitro

Endothall, an organic acid, is the least toxic structural analogue of Cantharidin that still inhibits PP2A[2].
Endothall inhibits preferentially hepatocellular carcinoma (HCC) growth and these new rat hepatocellular carcinoma lines may be useful for further biochemical and pharmacological studies on PP2A inhibitors, and for testing new forms of treatment of hepatic cell carcinomas. The HR-2, HR-3, HR-4, and Zajdela hepatocellular carcinomas are most sensitive to Endothall (IC50 of 1.7, 1.2, 0.9, and 1.7 µg/mL), whereas newborn rat hepatocytes growing exponentially in primary culture (IC50=6.2 µg/mL), rat DHD/K12 colon carcinoma cells (IC50=3.6 µg/mL), or human HT-29 colon carcinoma cells (IC50=4.9 µg/mL) were less sensitive[2].
Endothall inhibits the growth of HCC lines in culture more than that of normal hepatocytes or colon carcinomas, inducing mitotic arrest, followed by cell death. Endothall causes dose- and time-dependent cytostasis specifically in G2/M[2].
Endothall (3 µg/mL) inhibits the cell cycle at G2/M and subsequent apoptotic cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Endothall Related Antibodies
In Vivo

Endothall exhibits acute LD50 of 14 mg/kg in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

186.16

Formula

C8H10O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1C(C2CCC1O2)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (537.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3717 mL 26.8586 mL 53.7172 mL
5 mM 1.0743 mL 5.3717 mL 10.7434 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3717 mL 26.8586 mL 53.7172 mL 134.2931 mL
5 mM 1.0743 mL 5.3717 mL 10.7434 mL 26.8586 mL
10 mM 0.5372 mL 2.6859 mL 5.3717 mL 13.4293 mL
15 mM 0.3581 mL 1.7906 mL 3.5811 mL 8.9529 mL
20 mM 0.2686 mL 1.3429 mL 2.6859 mL 6.7147 mL
25 mM 0.2149 mL 1.0743 mL 2.1487 mL 5.3717 mL
30 mM 0.1791 mL 0.8953 mL 1.7906 mL 4.4764 mL
40 mM 0.1343 mL 0.6715 mL 1.3429 mL 3.3573 mL
50 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6859 mL
60 mM 0.0895 mL 0.4476 mL 0.8953 mL 2.2382 mL
80 mM 0.0671 mL 0.3357 mL 0.6715 mL 1.6787 mL
100 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
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Endothall Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endothall145-73-3EndothalPhosphatasePP2A inhibitorPP2Aherbicidecancer chemotherapyInhibitorinhibitorinhibit

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