1. GPCR/G Protein
    Membrane Transporter/Ion Channel
  2. Prostaglandin Receptor
    Potassium Channel
  3. Saikogenin D

Saikogenin D 

Cat. No.: HY-N4237
Handling Instructions

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores.

For research use only. We do not sell to patients.

Saikogenin D Chemical Structure

Saikogenin D Chemical Structure

CAS No. : 5573-16-0

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Description

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].

In Vitro

Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1].
Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].

Molecular Weight

472.70

Formula

C₃₀H₄₈O₄

CAS No.

5573-16-0

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Keywords:

Saikogenin DProstaglandin ReceptorPotassium ChannelKcsAanti-inflammatoryPGE2Ca2+prostaglandin E2Inhibitorinhibitorinhibit

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