Saikogenin D 

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca²⁺]i due to Ca²⁺ release from intracellular stores^[1][2].

Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca²⁺ ionophore A23187 in a concentration-dependent manner with an IC₅₀ value of 3 μM in C6 rat glioma cells^[1].
Saikogenin D (10-100 μM) elevates [Ca²⁺]i in a concentration-dependent manner with a EC₅₀ value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

472.70

C₃₀H₄₈O₄

5573-16-0

Solid

White to off-white

C[C@]12[C@]3(C(C=C[C@]1([H])[C@@]4([C@@]([C@@](C)([C@@H](O)CC4)CO)([H])CC2)C)=C5[C@](CO)(CCC(C)(C)C5)[C@H](O)C3)C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.J Pharm Pharmacol. 2006 Jun;58(6):859-66.  [Content Brief]

  [2]. Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69(8):765-7.  [Content Brief]