1. Anti-infection
  2. Parasite
  3. GNF179 Metabolite

GNF179 Metabolite 

Cat. No.: HY-15980
Handling Instructions

GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.

For research use only. We do not sell to patients.

GNF179 Metabolite Chemical Structure

GNF179 Metabolite Chemical Structure

CAS No. : 1310455-86-7

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Description

GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. IC50 value: Target: Anti-parasitic agent GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.

Molecular Weight

245.30

Formula

C₁₄H₁₆FN₃

CAS No.

1310455-86-7

SMILES

CC1(C2=NC(C3=CC=C(F)C=C3)=CN2CCN1)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GNF179 MetaboliteParasiteInhibitorinhibitorinhibit

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GNF179 Metabolite
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