1. NF-κB
  2. NF-κB

Ginsenoside C-K (Synonyms: Ginsenoside K; Ginsenoside compound K)

Cat. No.: HY-N0904 Purity: 98.06%
Data Sheet SDS Handling Instructions

Ginsenoside C-K(Ginsenoside compound K) is an intestinal microbiota metabolite of ginsenoside Rb1; possessing anti-proliferative and anti-inflammatory activities.

For research use only. We do not sell to patients.
Ginsenoside C-K Chemical Structure

Ginsenoside C-K Chemical Structure

CAS No. : 39262-14-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $123 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ginsenoside C-K(Ginsenoside compound K) is an intestinal microbiota metabolite of ginsenoside Rb1; possessing anti-proliferative and anti-inflammatory activities. IC50 value: Target: in vitro: C-K showed significant anti-proliferative effects in HCT-116 and SW-480 cells at concentrations of 30-50 μM. C-K activated expression of caspases 8 and 9, consistent with docking analysis [1]. In mononuclear phagocytes, C-K significantly repressed the activation of TLR4/lipopolysaccharide (LPS)-induced NF-kappaB and mitogen-activated protein kinases (MAPKs), as well as the secretion of pro-inflammatory cytokines. C-K competed with the synthetic glucocorticoid dexamethasone for binding to GR and activated glucocorticoid responsive element (GRE)-containing reporter plasmids in a dose-dependent manner [2]. in vivo: C-K treatment significantly ameliorated the pathologic manifestations of CIA mice, remarkably inhibited T lymphocyte proliferation, and marginally inhibited the proliferation of B lymphocytes. C-K treatment significantly suppressed TNF-α and anti-CII antibody levels, and increased IFN-γ level in the joints of CIA mice, but did not alter IL-4 production. Treatment of CIA mice with C-K significantly decreased the percentages of activated T cells, co-stimulatory molecule-expressing T cells and effector memory T cells, and increased the frequencies of naive T cells and regulatory T cells [3].

References
Molecular Weight

622.87

Formula

C₃₆H₆₂O₈

CAS No.

39262-14-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ginsenoside C-K
Cat. No.:
HY-N0904
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