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Art. -Nr.: HY-118283

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5-Hydroxylansoprazole

Name: 5-Hydroxylansoprazole
Brand: MedChemExpress
SKU: HY-118283
Price: 185.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: AG1908)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases.

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Reinheit : 99.75%
CAS. Nr.: 131926-98-2
Formel: C₁₆H₁₄F₃N₃O₃S
Molecular Weight:385.36

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

5-Hydroxylansoprazole Chemical Structure

CAS. Nr.: 131926-98-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Proton Pump^[1]

Chemical Information

CAS. Nr. 131926-98-2
Appearance Solid
Molecular Weight 385.36
Formel C₁₆H₁₄F₃N₃O₃S
Color White to off-white
SMILES

OC1=CC=C2N=C(NC2=C1)S(CC3=NC=CC(OCC(F)(F)F)=C3C)=O
Synonyms

AG1908
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Acta Pharm Sin B

Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition. [Abstract]

2024 Apr;14(4):1711-1725. PMID: 38572109

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (324.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5950 mL

12.9749 mL

25.9498 mL

5 mM

0.5190 mL

2.5950 mL

5.1900 mL

10 mM

0.2595 mL

1.2975 mL

2.5950 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220. [Content Brief]

[2]. Katarína Kostolanská, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955–2963(2019).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5950 mL	12.9749 mL	25.9498 mL	64.8744 mL
	5 mM	0.5190 mL	2.5950 mL	5.1900 mL	12.9749 mL
	10 mM	0.2595 mL	1.2975 mL	2.5950 mL	6.4874 mL
	15 mM	0.1730 mL	0.8650 mL	1.7300 mL	4.3250 mL
	20 mM	0.1297 mL	0.6487 mL	1.2975 mL	3.2437 mL
	25 mM	0.1038 mL	0.5190 mL	1.0380 mL	2.5950 mL
	30 mM	0.0865 mL	0.4325 mL	0.8650 mL	2.1625 mL
	40 mM	0.0649 mL	0.3244 mL	0.6487 mL	1.6219 mL
	50 mM	0.0519 mL	0.2595 mL	0.5190 mL	1.2975 mL
	60 mM	0.0432 mL	0.2162 mL	0.4325 mL	1.0812 mL
	80 mM	0.0324 mL	0.1622 mL	0.3244 mL	0.8109 mL
	100 mM	0.0259 mL	0.1297 mL	0.2595 mL	0.6487 mL

Bioz

Keywords

5-Hydroxylansoprazole

1 Cited Publications

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Biologische Aktivität
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- IC₅₀ & Target
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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5-Hydroxylansoprazole

Publications Citing Use of MedChemExpress (MCE) 5-Hydroxylansoprazole