1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Dasatinib metabolite M6

Dasatinib metabolite M6 (Synonyms: Dasatinib carboxylic acid)

Cat. No.: HY-131669 Purity: 99.23%
Handling Instructions

Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor.

For research use only. We do not sell to patients.

Dasatinib metabolite M6 Chemical Structure

Dasatinib metabolite M6 Chemical Structure

CAS No. : 910297-53-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 331 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor[1].

Molecular Weight

501.99

Formula

C₂₂H₂₄ClN₇O₃S

CAS No.

910297-53-9

SMILES

O=C(O)CN1CCN(C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C)C=CC=C4Cl)=O)S3)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (199.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9921 mL 9.9604 mL 19.9207 mL
5 mM 0.3984 mL 1.9921 mL 3.9841 mL
10 mM 0.1992 mL 0.9960 mL 1.9921 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Dasatinib metabolite M6Dasatinib carboxylic acidDasatinib metabolite M 6Dasatinib metabolite M-6Drug MetaboliteDasatiniboxidativemetaboliteInhibitorinhibitorinhibit

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Product Name:
Dasatinib metabolite M6
Cat. No.:
HY-131669
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