Bcr-Abl Inhibitors

Bcr-Abl, IC₅₀: 1.0 nM

Abl, Kd: 91 nM
ABL(E255K), Kd: 120 nM
ABL(T315I), Kd: 170 nM

Abl1, IC₅₀: 4.9 μM

Bcr-Abl, IC₅₀: 1.0 nM

Abl, IC₅₀: 4 nM
ABL-T315I, IC₅₀: 14 nM

ABL(T315I), IC₅₀: 4 nM

Abl1, IC₅₀: 325 nM

Abl, IC₅₀: 0.37 nM

Abl, IC₅₀: 1.7 nM

Bcr-Abl, IC₅₀: 1.0 nM

Abl, IC₅₀: 8 nM

Bcr-Abl

BCR-ABL1, IC₅₀: 7 nM

Bcr-Abl

Bcr-Abl, IC₅₀: 5 nM (p210^Bcr-Abl kinase)

Abl1, IC₅₀: 6.95 μM

c-Abl, IC₅₀: 1.2 nM

BCR-ABL1

Bcr-Abl, IC₅₀: 19.9 nM
Bcr-Abl^T315I, IC₅₀: 15.4 nM

Bcr-Abl^WT
Bcr-Abl^T315I

Abl1, IC₅₀: 8.7 nM

WT BCR-ABL
T315I-BCR-ABL

Bcr-Abl^T315I, IC₅₀: 15.4 nM
Bcr-Abl, IC₅₀: 19.9 nM

Ba/F₃Bcr-Abl^T3151, IC₅₀: ≤100 nM

ABL wt, IC₅₀: 2 nM
ABL-T315I, IC₅₀: 0.2 nM

ABL(T315I), : 4 nM

Abl, IC₅₀: 3.6 nM

Bcr-Abl

Abl, IC₅₀: 26 nM

Bcr-Abl, IC₅₀: 56.2 nM

BCR-ABL1

Bcr-Abl, DC₅₀: 30 nM

Abl1, IC₅₀: <0.5 nM

Abl, IC₅₀: 0.021 μM

Abl, IC₅₀: 70 nM

Bcr-Abl^WT, DC₅₀: 200 nM

Bcr-Abl^WT, DC₅₀: 20 nM

Abl1, CC₅₀: 0.8 μM

Bcr-Abl, DC₅₀: 0.18 μM

Bcr-Abl, EC₅₀: 69 nM

Abl1

Bcr-Abl^WT, DC₅₀: 10 nM

Abl

Bcr-Abl

c-Abl, IC₅₀: 16.6 nM

Bcr-Abl, DC₅₀: 1.56 nM

Abl1, IC₅₀: 83.6 nM

Abl, IC₅₀: 0.54 nM
Abl, DC₅₀: 10 nM

Abl1

WT BCR-ABL, IC₅₀: 1 nM
Bcr-Abl^T315I, IC₅₀: 0.8 nM