19,20-Epoxycytochalasin C 

19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity^[1].

19,20-Epoxycytochalasin C shows moderate toxicity to cell line SK-MEL with an IC₅₀ of 8.02 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Evaluation of in vivo antimalarial activity of 19,20-Epoxycytochalasin C in a mouse model at 100 mg/kg dose shows that this compound has weak suppressive antiplasmodial activity and is toxic to animals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

523.62

C₃₀H₃₇NO₇

189351-79-9

CC(O[C@H]([C@@]1([H])[C@@]([C@@](O)(C2=O)C)([H])O1)[C@@]([C@](/C=C/C[C@@H]2C)([H])[C@@H]3O)(C(N4)=O)[C@](C(C)=C3C)([H])[C@@H]4CC5=CC=CC=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mallika Kumarihamy, et al. Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf. Molecules. 2019 Feb 21;24(4):777.  [Content Brief]