Carviolin
Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities.
For research use only. We do not sell to patients.
- CAS No.: 478-35-3
- Formula: C16H12O6
- Molecular Weight:300.26
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-128140
Z-FY-CHOCTSL Inhibitor -
HY-136571
GSK046BET BD2 Inhibitor -
HY-131140
BD750Immunosuppressant -
HY-W015210
4-Deoxypyridoxine hydrochlorideBiochemical Assay Reagent -
HY-126489
Tetromycin B -
HY-N1418
(S)-(-)-TetrahydroberberineInsecticide -
HY-N9194
5-Methoxycanthin-6-oneLeishmanicidal Agent -
HY-N8385
19,20-Epoxycytochalasin CAntiplasmodial Agent -
HY-138223
6-PrenylindoleAntifungal Agent -
HY-138074
Milbemycin A4 oximeNematicide -
HY-139090
3-Oxobetulin acetateAntancer -
HY-126638
Marcfortine ANematode
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
>100 μM
Compound: 9
|
Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
|
[PMID: 21146414] |
| K562 | IC50 |
>100 μM
Compound: 9
|
Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay
Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay
|
[PMID: 21146414] |
| U-937 | IC50 |
>100 μM
Compound: 9
|
Cytotoxicity against human U937 cells after 24 hrs by MTT assay
Cytotoxicity against human U937 cells after 24 hrs by MTT assay
|
[PMID: 21146414] |
Chemical Information
-
CAS No. 478-35-3
-
Molecular Weight 300.26
-
Formula C16H12O6
-
SMILES
O=C1C2=C(C=C(CO)C=C2OC)C(C3=CC(O)=CC(O)=C13)=O
-
Structure Classification
-
Initial Source
Penicillium dravuni
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
-
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carviolin Related Classifications
HY-N10267 Related Classifications
Powered by Bioz