1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. Z-FY-CHO

Z-FY-CHO (Synonyms: Z-Phe-Tyr-CHO)

Cat. No.: HY-128140
Handling Instructions

Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor.

For research use only. We do not sell to patients.

Z-FY-CHO Chemical Structure

Z-FY-CHO Chemical Structure

CAS No. : 167498-29-5

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Description

Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor[1][2].

IC50 & Target

Cathepsin L (CTSL)[1]

In Vitro

Z-FY-CHO (10 µM, for 1 h) pretreatment alleviated cell death induced by 6-OHDA. Z-FY-CHO inhibits the increase in CTSL protein expression in 6-OHDA-treated SH-SY5Y cells. Treatment with Z-FY-CHO caused more LC3-II and less P62 expression in SH-SY5Y cells treated with 6-OHDA, indicating enhancing autophagy activity, and Z-FY-CHO blocks activation of caspase-3 and PARP[1].
Treatment with the specific cathepsin L inhibitor Z-FY-CHO (10 μM) or transfection with cathepsin L shRNA significantly increased the radiosensitivity of U251 cells. Both suppression and knockdown of cathepsin L in U251 cells increased irradiation-induced DNA damage and G2/M phase cell cycle arrest. Both suppression and knockdown of cathepsin L in U251 cells also increased irradiation-induced apoptosis, as shown by the increased levels of Bax and decreased levels of Bcl-2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.50

Formula

C₂₆H₂₆N₂O₅

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Z-FY-CHO
Cat. No.:
HY-128140
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