Camostat mesylate (Synonyms: Camostat mesilate; FOY305; FOY-S980)

Name: Camostat mesylate
Brand: MedChemExpress
SKU: HY-13512
Rating: 5.0 (43 reviews)

Cat. No.: HY-13512 Purity: 99.94%: Data Sheet
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Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase.

For research use only. We do not sell to patients.

CAS No. : 59721-29-8

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 43 publication(s) in Google Scholar

Other Forms of Camostat mesylate:

Camostat In-stock
Camostat mesylate (Standard) In-stock

43 Publications Citing Use of MCE Camostat mesylate

Bio/Physico-chemical Assay

RT-PCR

: Camostat mesylate purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2025 Nov;10(11):2860-2874.; TMPRSS2 inhibitor Camostat mesylate (66.7 μM; 1 h; 37 ℃) dose-dependently inhibited pseudovirus entry of HKU25 clade or HKU5-1 in Caco-2 cells overexpressing the indicated ACE2s.

: Camostat mesylate purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2024 Sep;9(9):2383-2394. [Abstract]; TMPRSS2 inhibitor Camostat mesylate (0.01-100 μM) inhibited the WT pseudovirus approximately 3-fold better than the ΔFCS pseudovirus in VeroE6 cells overexpressing hACE2 and TMPRSS2 (VAT cells).

: Camostat mesylate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Mar 11;7(1):83. [Abstract]; Camostat mesylate (2-20 μM; 1 h) inhibited SARS-CoV-2 infection of Caco2 cells in a dose-dependent manner.

: Camostat mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2022 Mar;603(7902):693-699. [Abstract]; VeroE6-TMPRSS2 cells were pretreated with Camostat mesylate (1–50 μM; 2 h) followed by transduction with pseudoviruses carrying the spike protein of SARS-CoV-2 WT, Alpha, Beta, Delta, or Omicron. Pseudovirus entry was quantified by measuring the luciferase signal of the cell lysates at 24 h.p.i.

: Camostat mesylate purchased from MedChemExpress. Usage Cited in: Nature. 2022 Mar;603(7902):693-699. [Abstract]; VeroE6-TMPRSS2 cells were pretreated with Camostat mesylate (1-50 μM; 2 h) and challenged with the indicated authentic SARS-CoV-2 variants at 0.1 m.o.i.. The amount of viral subgenomic envelope RNA in the collected cell lysates at 24 h.p.i. was determined using RT–qPCR.

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	> 20 μM Compound: CAMOSTAT	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	10.21203/rs.3.rs-23951/v1
Caco-2	IC₅₀	0.64 μM Compound: CAMOSTAT	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

In Vitro

Camostat mesylate (Camostat mesilate) inhibits both monocyte chemoattractant protein-1 (MCP-1) and TNF-α production from monocytes, and proliferation and MCP-1 production from PSCs^[1].
Camostat mesylate, a trypsin-like protease inhibitor, provides a potent (IC₅₀=50 nM) and prolongs attenuation of ENaC function in human airway epithelial cell models that is reversible upon the addition of excess trypsin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Camostat mesilate (30 mg/kg; p.o.; twice a day for 9 days) blocks the spread and pathogenesis of SARS-CoV in a pathogenic mouse model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 week old female BALB/c mice (lethal SARS-CoV infection model)^[4]
Dosage:	30 mg/kg
Administration:	P.o.; twice a day for 9 days
Result:	Effective in protecting mice against death due to a lethal infection by SARS-CoV, with a survival rate of ∼60%.

Clinical Trial

Molecular Weight

494.52

Formula

C₂₁H₂₆N₄O₈S

CAS No.

59721-29-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (252.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (101.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0222 mL	10.1108 mL	20.2216 mL
5 mM	0.4044 mL	2.0222 mL	4.0443 mL
10 mM	0.2022 mL	1.0111 mL	2.0222 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (25.28 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (273 KB) SDS (537 KB)

COA (246 KB) HNMR (196 KB) RP-HPLC (247 KB) LCMS (339 KB)

Handling Instructions (2659 KB)

References

[1]. Gibo J, et al. Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity. Lab Invest. 2005;85(1):75‐89. [Content Brief]

[2]. Uno Y. Camostat mesilate therapy for COVID-19 [published online ahead of print, 2020 Apr 29]. Intern Emerg Med. 2020;1‐2. [Content Brief]

[3]. Coote K, et al. Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease. J Pharmacol Exp Ther. 2009;329(2):764‐774. [Content Brief]

[4]. Zhou Y, Vedantham P, Lu K, et al. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015;116:76‐84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.0222 mL	10.1108 mL	20.2216 mL	50.5541 mL
	5 mM	0.4044 mL	2.0222 mL	4.0443 mL	10.1108 mL
	10 mM	0.2022 mL	1.0111 mL	2.0222 mL	5.0554 mL
	15 mM	0.1348 mL	0.6741 mL	1.3481 mL	3.3703 mL
	20 mM	0.1011 mL	0.5055 mL	1.0111 mL	2.5277 mL
	25 mM	0.0809 mL	0.4044 mL	0.8089 mL	2.0222 mL
	30 mM	0.0674 mL	0.3370 mL	0.6741 mL	1.6851 mL
	40 mM	0.0506 mL	0.2528 mL	0.5055 mL	1.2639 mL
	50 mM	0.0404 mL	0.2022 mL	0.4044 mL	1.0111 mL
	60 mM	0.0337 mL	0.1685 mL	0.3370 mL	0.8426 mL
	80 mM	0.0253 mL	0.1264 mL	0.2528 mL	0.6319 mL
	100 mM	0.0202 mL	0.1011 mL	0.2022 mL	0.5055 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Camostat mesylate Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Camostat mesylate (Synonyms: Camostat mesilate; FOY305; FOY-S980)

Customer Review

Other Forms of Camostat mesylate:

Camostat mesylate Related Antibodies

43 Publications Citing Use of MCE Camostat mesylate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Camostat mesylate Related Antibodies

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Complete Stock Solution Preparation Table

Camostat mesylate Related Classifications

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