1. Metabolic Enzyme/Protease
    Anti-infection
  2. Ser/Thr Protease
    SARS-CoV
  3. Camostat mesylate

Camostat mesylate (Synonyms: Camostat mesilate; FOY305; FOY-S980)

Cat. No.: HY-13512 Purity: 99.69%
Handling Instructions

Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase.

For research use only. We do not sell to patients.

Camostat mesylate Chemical Structure

Camostat mesylate Chemical Structure

CAS No. : 59721-29-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase[1][2][3].

In Vitro

Camostat mesylate (Camostat mesilate) inhibits both monocyte chemoattractant protein-1 (MCP-1) and TNF-α production from monocytes, and proliferation and MCP-1 production from PSCs[1].
Camostat mesylate, a trypsin-like protease inhibitor, provides a potent (IC50=50 nM) and prolongs attenuation of ENaC function in human airway epithelial cell models that is reversible upon the addition of excess trypsin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Camostat mesilate (30 mg/kg; p.o.; twice a day for 9 days) blocks the spread and pathogenesis of SARS-CoV in a pathogenic mouse model[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week old female BALB/c mice (lethal SARS-CoV infection model)[4]
Dosage: 30 mg/kg
Administration: P.o.; twice a day for 9 days
Result: Effective in protecting mice against death due to a lethal infection by SARS-CoV, with a survival rate of ∼60%.
Clinical Trial
Molecular Weight

494.52

Formula

C₂₁H₂₆N₄O₈S

CAS No.

59721-29-8

SMILES

O=C(OCC(N(C)C)=O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (252.77 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (101.11 mM)

Ethanol : 2 mg/mL (4.04 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0222 mL 10.1108 mL 20.2216 mL
5 mM 0.4044 mL 2.0222 mL 4.0443 mL
10 mM 0.2022 mL 1.0111 mL 2.0222 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.69%

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Keywords:

CamostatCamostat mesilate FOY305 FOY-S980FOY305FOY 305FOY-305Ser/Thr ProteaseSARS-CoVSerine proteasesSerine endopeptidasesThreonine proteasesSARS coronavirusoralchronicpancreatitisTMPRSS2virusSARS-CoV-2coronavirusInhibitorinhibitorinhibit

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Product Name:
Camostat mesylate
Cat. No.:
HY-13512
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