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Results for "

CTSL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (6) CCR (1) Cytochrome P450 (1) Filovirus (1) Parasite (1) SARS-CoV (4) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Infection (5) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158022

CTSL/CAPN1-IN-1	Cathepsin	Infection Inflammation/Immunology
CTSL/CAPN1-IN-1 (compound 14a) is an oral active *CTSL* and CAPN1 inhibitor with the IC₅₀ values of 3.34 nM and 375.1 nM for CTSL and CAPN1, respectively. CTSL/CAPN1-IN-1 shows anticoronaviral activity and anti-inflammatory effect .

HY-161342

CTSL/CAPN1-IN-2	Cathepsin SARS-CoV	Infection Inflammation/Immunology
CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both *CTSL* and CAPN1, with IC₅₀ values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry .

HY-163029

CTSL/B-IN-1	Cathepsin SARS-CoV	Infection
CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins *CTSL/CTSB* and TMPRSS2 with IC₅₀s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research .

HY-RS03340

CTSL Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CTSL Human Pre-designed siRNA Set A contains three designed siRNAs for CTSL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CTSL Human Pre-designed siRNA Set A CTSL Human Pre-designed siRNA Set A

HY-RS03341

Ctsl Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ctsl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ctsl Mouse Pre-designed siRNA Set A Ctsl Mouse Pre-designed siRNA Set A

HY-RS03342

Ctsl Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ctsl Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ctsl Rat Pre-designed siRNA Set A Ctsl Rat Pre-designed siRNA Set A

HY-128140

Z-FY-CHO

2 Publications Verification

Z-Phe-Tyr-CHO
Cathepsin Neurological Disease Metabolic Disease

Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor .

Z-FY-CHO 2 Publications Verification Z-Phe-Tyr-CHO	Cathepsin	Neurological Disease Metabolic Disease
Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor .

HY-137978

Ezurpimtrostat GNS561	Others	Metabolic Disease Inflammation/Immunology Cancer
Ezurpimtrostat (compound 2-2) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases (extracted from patent WO2020048694 A1) .

HY-157477

SARS-CoV-2 3CLpro-IN-22	SARS-CoV Cathepsin	Infection
SARS-CoV-2 3CLpro-IN-22 (Compound 17) is a cathepsin L (CTSL ) inhibitor with an IC₅₀ value of 32.5 nM. SARS-CoV-2 3CLpro-IN-22 can be used for the study of SARS-CoV-2 virus .

HY-137978A

Ezurpimtrostat hydrochloride GNS561 hydrochloride	Others	Metabolic Disease Inflammation/Immunology Cancer
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .

HY-119293

K777 1 Publications Verification	Cathepsin CCR Cytochrome P450 Parasite SARS-CoV Filovirus	Infection Cancer
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively .

Species:	Human (4) Mouse (1)
Tag:	His (5)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P7754

	Cathepsin L1 Protein, Human (HEK293, His) rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL	Human	HEK293
	Cathepsin L1 Protein, Human (HEK293, His) is a major cysteine protease that plays a major role in intracellular protein catabolism.

HY-P7754A

	Cathepsin L1 Protein, Human (HEK293, C-His) rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL	Human	HEK293
	Cathepsin L1 protein is a thiol protease that plays a key role in lysosomal protein degradation, affecting cellular functions such as turnover, antigen processing, and bone remodeling. It dissolves cross-linked TG/thyroglobulin, releasing the thyroid hormone thyroxine (T4) in the thyroid follicular cavity. Cathepsin L1 Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin L1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cathepsin L1 Protein, Human (HEK293, C-His) is 316 a.a., with molecular weight of ~32.8 kDa.

HY-P7755A

	Cathepsin L2 Protein, Human (HEK293, His, solution) Cathepsin L2; Cathepsin U; Cathepsin V; CTSL2; CATL2; CTSU; CTSV	Human	HEK293
	Cathepsin L2 is a cysteine protease thought to play a crucial role in corneal physiology, but its specific function and mechanism are still under investigation. The unique properties of cathepsin L2 suggest that it may be involved in important cellular and molecular events within the cornea, underscoring its importance in maintaining ocular tissue health. Cathepsin L2 Protein, Human (HEK293, His, solution) is the recombinant human-derived Cathepsin L2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cathepsin L2 Protein, Human (HEK293, His, solution) is 317 a.a., with molecular weight of ~33-38 kDa.

HY-P7753

	Cathepsin L1 Protein, Mouse (HEK293, His) rMuCathepsin L, His; Cathepsin L1; Major excreted protein; p39 cysteine proteinase; CTSL1	Mouse	HEK293
	Cathepsin L Protein, Mouse (HEK293, His) is a lysosomal acid cysteine protease, which is associated with tumor occurrence, development, and metastasis.

HY-P7755

	Cathepsin L2 Protein, Human (HEK293, His) rHuCathepsin L2, His; Cathepsin L2; Cathepsin U; Cathepsin V; CTSL2; CATL2; CTSU; CTSV	Human	HEK293
	Cathepsin L2 Protein, Human (HEK293, His) is a functional cysteine proteinase, mainly expressed in the cornea, testis, thymus, and epidermis.


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