CTSL/B-IN-1 

CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC₅₀s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research^[1].

IC50: 1.38 μM (TMPRSS2)^[1], IC50: 2.13/64.07 nM (CTSL/CTSB)^[1]

CTSLCTSB-IN-1 (10^-3-10⁵ nM,1h) shows significant antiviral efficacy in Calu-3 cells infected with clinical SARS-CoV-2 isolate Delta strain or omicron strain BA.2 ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

765.92

C₄₁H₄₇N₇O₆S

O=C(N[C@H](C(N[C@@H](CCC1=CC=CC=C1)/C=C/S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N(CC4)CCN4CCOC(C5=CC=C(C=C5)/N=C(N)\N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Haitao Yang, et al. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun,.2023，14，7574.  [Content Brief]