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Ezurpimtrostat hydrochloride (Synonyms: GNS561 hydrochloride)

Cat. No.: HY-137978A
Handling Instructions

Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .

For research use only. We do not sell to patients.

Ezurpimtrostat hydrochloride Chemical Structure

Ezurpimtrostat hydrochloride Chemical Structure

CAS No. : 1914148-73-4

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1].

In Vivo

Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

459.45

Formula

C25H32Cl2N4

CAS No.
SMILES

CC(NC1CCN(C2=CC(NCC3=CC=C(Cl)C=C3)=NC4=CC=CC=C24)CC1)(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1765 mL 10.8826 mL 21.7652 mL
5 mM 0.4353 mL 2.1765 mL 4.3530 mL
10 mM 0.2177 mL 1.0883 mL 2.1765 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Ezurpimtrostat hydrochloride
Cat. No.:
HY-137978A
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