1914148-73-4
Chemical Structure
Ezurpimtrostat hydrochloride
Synonym(s): GNS561 hydrochloride
- CAS No.: 1914148-73-4
- Formula:C25H32Cl2N4
- Molecular Weight:459.45
IUPAC Name: 4-(4-(tert-butylamino)piperidin-1-yl)-N-(4-chlorobenzyl)quinolin-2-amine hydrochloride
InChIKey: DLXMKLHCUTYCGO-UHFFFAOYSA-N
SMILES: CC(NC1CCN(C2=CC(NCC3=CC=C(Cl)C=C3)=NC4=CC=CC=C24)CC1)(C)C.[H]Cl
Biological Activity: Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally active PPT1 inhibitor, autophagy inhibitor, immunomodulator, anti-inflammatory agent, and anticancer agent. Ezurpimtrostat hydrochloride inhibits PPT1, dysregulates lysosomal function, redistributes mTOR, and induces apoptosis. Ezurpimtrostat hydrochloride reduces IFN‑α, CRP, immune complex deposition, and SARS‑CoV‑2 viral load. Ezurpimtrostat hydrochloride can be used for the study of systemic lupus erythematosus, SARS‑CoV‑2, hepatocellular carcinoma, fibrosis, and related disorders[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ezurpimtrostat hydrochloride | 99.26% | Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally active PPT1 inhibitor, autophagy inhibitor, immunomodulator, anti-inflammatory agent, and anticancer agent. Ezurpimtrostat hydrochloride inhibits PPT1, dysregulates lysosomal function, redistributes mTOR, and induces apoptosis. Ezurpimtrostat hydrochloride reduces IFN‑α, CRP, immune complex deposition, and SARS‑CoV‑2 viral load. Ezurpimtrostat hydrochloride can be used for the study of systemic lupus erythematosus, SARS‑CoV‑2, hepatocellular carcinoma, fibrosis, and related disorders. | ||||||||||||||||||||
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- [1]. Toumi E, et al. GNS561 (ezurpimtrostat), a small basic lipophilic molecule, prevents lupus phenotype in a pristane-induced lupus mouse model. Br J Pharmacol. 2025;182(16):3786-3799. [Content Brief]
- [2]. Bestion E, et al. GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition. Viruses. 2022;14(1):132. Published 2022 Jan 12. [Content Brief]
- [3]. Brun S, et al. GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions. Autophagy. 2022;18(3):678-694. [Content Brief]
- [4]. Halfon P, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases, EP, EP3620164A1, 2020-03-11.
Keywords
