L-Allothreonine
Based on 1 Customer Validation
L-Allothreonine (H-allo-Thr-OH) is a diastereomer of L-Threonine (HY-N0658) and belongs to non-proteinogenic amino acids. L-Allothreonine serves as a non-natural substrate for yeast Cystathionine β-Synthase (HY-E70078), which is used to investigate the substrate specificity and reaction mechanism of the enzyme.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 28954-12-3
- Formula: C4H9NO3
- Molecular Weight:119.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
2.8 μg/mL
Compound: F2-Thr (2S,3S)
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Tested for the effect of stereochemistry on the growth of L1210 mouse leukemia cell line in vitro
Tested for the effect of stereochemistry on the growth of L1210 mouse leukemia cell line in vitro
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10.1016/S0960-894X(01)81041-6 |
Allothreonine reacts with the pyridoxal phosphate cofactor of this enzyme to form a stable 3-methylaminoacrylate intermediate, which then reacts with L-homocysteine to produce 3-methyl-L-cystathionine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28954-12-3
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Appearance Solid
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Molecular Weight 119.12
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Formula C4H9NO3
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Color White to off-white
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SMILES
N[C@@H]([C@@H](O)C)C(O)=O
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Synonyms
H-allo-Thr-OH
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 12.5 mg/mL (104.94 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (308 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.3949 mL | 41.9745 mL | 83.9490 mL | 209.8724 mL |
| 5 mM | 1.6790 mL | 8.3949 mL | 16.7898 mL | 41.9745 mL | |
| 10 mM | 0.8395 mL | 4.1974 mL | 8.3949 mL | 20.9872 mL | |
| 15 mM | 0.5597 mL | 2.7983 mL | 5.5966 mL | 13.9915 mL | |
| 20 mM | 0.4197 mL | 2.0987 mL | 4.1974 mL | 10.4936 mL | |
| 25 mM | 0.3358 mL | 1.6790 mL | 3.3580 mL | 8.3949 mL | |
| 30 mM | 0.2798 mL | 1.3991 mL | 2.7983 mL | 6.9957 mL | |
| 40 mM | 0.2099 mL | 1.0494 mL | 2.0987 mL | 5.2468 mL | |
| 50 mM | 0.1679 mL | 0.8395 mL | 1.6790 mL | 4.1974 mL | |
| 60 mM | 0.1399 mL | 0.6996 mL | 1.3991 mL | 3.4979 mL | |
| 80 mM | 0.1049 mL | 0.5247 mL | 1.0494 mL | 2.6234 mL | |
| 100 mM | 0.0839 mL | 0.4197 mL | 0.8395 mL | 2.0987 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Allothreonine Related Classifications
HY-W008315 Related Classifications
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