Cat. No.: HY-N0658

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L-Threonine

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 72-19-5
Formula: C₄H₉NO₃
Molecular Weight:119.12

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

L-Threonine Chemical Structure

CAS No.: 72-19-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed^[1]^[2].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

L-Threonine is used almost exclusively as a feed additive, primarily in feed for pigs and poultry^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 72-19-5
Appearance Solid
Molecular Weight 119.12
Formula C₄H₉NO₃
Color White to off-white
SMILES

N[C@@H]([C@H](O)C)C(O)=O
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Acta Pharm Sin B

Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1 α/NF- κ B feedback pathway to inhibit liver fibrosis. [Abstract]

2022 Sep;12(9):3618-3638. PMID: 36176909
Amino Acids

Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]

2024 Sep 18;56(1):56. PMID: 39292313

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (279.80 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

8.3949 mL

41.9745 mL

83.9490 mL

5 mM

1.6790 mL

8.3949 mL

16.7898 mL

10 mM

0.8395 mL

4.1974 mL

8.3949 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (419.74 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao H, et al. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018 Jul;102(13):5505-5518. [Content Brief]

[2]. Rie, et al. "l-Threonine." Amino Acid Biosynthesis Pathways, Regulation and Metabolic Engineering (2006): 71-92.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	8.3949 mL	41.9745 mL	83.9490 mL	209.8724 mL
	5 mM	1.6790 mL	8.3949 mL	16.7898 mL	41.9745 mL
	10 mM	0.8395 mL	4.1974 mL	8.3949 mL	20.9872 mL
	15 mM	0.5597 mL	2.7983 mL	5.5966 mL	13.9915 mL
	20 mM	0.4197 mL	2.0987 mL	4.1974 mL	10.4936 mL
	25 mM	0.3358 mL	1.6790 mL	3.3580 mL	8.3949 mL
	30 mM	0.2798 mL	1.3991 mL	2.7983 mL	6.9957 mL
	40 mM	0.2099 mL	1.0494 mL	2.0987 mL	5.2468 mL
	50 mM	0.1679 mL	0.8395 mL	1.6790 mL	4.1974 mL
	60 mM	0.1399 mL	0.6996 mL	1.3991 mL	3.4979 mL
	80 mM	0.1049 mL	0.5247 mL	1.0494 mL	2.6234 mL
	100 mM	0.0839 mL	0.4197 mL	0.8395 mL	2.0987 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Threonine

Metabolism/Protease Compound Library

Natural Product Library

FDA-Approved Drug Library

Human Endogenous Metabolite Compound Library

Drug Repurposing Compound Library

Medicine Food Homology Compound Library

FDA Approved & Pharmacopeial Drug Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Food Additive Library

Food-Sourced Compound Library

Inactive Ingredient Library

Rare Diseases Drug Library

Human Metabolite Library

Anti-Aging Natural Product Library

Off-patent Drug Library

Animal-Sourced Natural Product Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Dietary Supplement Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

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Mongolian Medicine Compound Library

Chinese Baijiu Compound Library

Flavors and Fragrances Compound Library

Natural Product Diversity Scaffold Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Lactic Acid Metabolite Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) L-Threonine

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Threonine Related Classifications

HY-N0658 Related Classifications