L-Threonine-d2
Based on 1 Customer Validation
L-Threonine-d2 is the deuterium labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 1202936-45-5
- Formula: C4H7D2NO3
- Molecular Weight:121.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1202936-45-5
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Unlabeled Cas 72-19-5
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Appearance Solid
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Molecular Weight 121.13
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Formula C4H7D2NO3
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Color White to off-white
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SMILES
C[C@](O)([2H])[C@@](N)([2H])C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (412.78 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Zhao H, et al. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018 Jul;102(13):5505-5518. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.2556 mL | 41.2780 mL | 82.5559 mL | 206.3898 mL |
| 5 mM | 1.6511 mL | 8.2556 mL | 16.5112 mL | 41.2780 mL | |
| 10 mM | 0.8256 mL | 4.1278 mL | 8.2556 mL | 20.6390 mL | |
| 15 mM | 0.5504 mL | 2.7519 mL | 5.5037 mL | 13.7593 mL | |
| 20 mM | 0.4128 mL | 2.0639 mL | 4.1278 mL | 10.3195 mL | |
| 25 mM | 0.3302 mL | 1.6511 mL | 3.3022 mL | 8.2556 mL | |
| 30 mM | 0.2752 mL | 1.3759 mL | 2.7519 mL | 6.8797 mL | |
| 40 mM | 0.2064 mL | 1.0319 mL | 2.0639 mL | 5.1597 mL | |
| 50 mM | 0.1651 mL | 0.8256 mL | 1.6511 mL | 4.1278 mL | |
| 60 mM | 0.1376 mL | 0.6880 mL | 1.3759 mL | 3.4398 mL | |
| 80 mM | 0.1032 mL | 0.5160 mL | 1.0319 mL | 2.5799 mL | |
| 100 mM | 0.0826 mL | 0.4128 mL | 0.8256 mL | 2.0639 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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