2. Isotope-Labeled Compounds
  3. Internal Standard for Clinical Mass Spectrometry
  4. Isotope-Labeled Amino Acids

Isotope-Labeled Amino Acids

Natural amino acids consist of four key elements: 1H (hydrogen), 12C (carbon), 14N (nitrogen), and 16O (oxygen). When one or more atoms are replaced by isotopes or “heavy” atoms (such as 1H by 2H (D), 12C by 13C, 14N by 15N, and 16O by 17O or 18O), the resulting amino acids are called isotope-labeled amino acids. While most isotope-labeled amino acids and their natural counterparts share identical structures and properties, their presence and levels can be detected and measured by analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), with MS being the preferred method. Isotope-labeled amino acids have become an increasingly important tool for proteomic research.

Isotope-Labeled Amino Acids (531):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0623S
    L-Tryptophan-d5 62595-11-3 99.94%
    L-Tryptophan-d5 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.
    L-Tryptophan-d<sub>5</sub>
  • HY-N0486S9
    L-Leucine-d3 87828-86-2 99.98%
    L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-d<sub>3</sub>
  • HY-N0455AS8
    L-Arginine-13C6,15N4 hydrochloride 202468-25-5 99.85%
    L-Arginine-13C6,15N4 (hydrochloride) is the 13C- and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
    L-Arginine-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>4</sub> hydrochloride
  • HY-N0215S12
    L-Phenylalanine-d5 56253-90-8 99.90%
    L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-d<sub>5</sub>
  • HY-N0390S8
    L-Glutamine-15N2 204451-48-9 99.10%
    L-Glutamine-15N2 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
    L-Glutamine-<sup>15</sup>N<sub>2</sub>
  • HY-N0455AS6
    L-Arginine-13C6 hydrochloride 201740-91-2 99.00%
    L-Arginine-13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
    L-Arginine-<sup>13</sup>C<sub>6</sub> hydrochloride
  • HY-N0650S
    L-Serine-13C3 201595-68-8 99.95%
    L-Serine-13C3 is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
    L-Serine-<sup>13</sup>C<sub>3</sub>
  • HY-N0067S
    γ-Aminobutyric acid-d6 70607-85-1 99.92%
    γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors).
    γ-Aminobutyric acid-d<sub>6</sub>
  • HY-N0623S2
    L-Tryptophan-13C11 202114-65-6 99.78%
    L-Tryptophan-13C11 is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.
    L-Tryptophan-<sup>13</sup>C<sub>11</sub>
  • HY-N0390S9
    L-Glutamine-15N-1 59681-32-2 98.0%
    L-Glutamine-15N-1 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
    L-Glutamine-<sup>15</sup>N-1
  • HY-N0470S3
    L-Lysine-13C6,15N2 hydrochloride 1200447-00-2 99.87%
    L-Lysine-13C6,15N2 (hydrochloride) is the 13C- and 15N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>2</sub> hydrochloride
  • HY-D0187S
    L-Glutathione reduced-13C2,15N 815610-65-2 ≥99.99%
    L-Glutathione reduced-13C2,15N is the 13C- and 15N-labeled L-Glutathione reduced. L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
    L-Glutathione reduced-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-I1124
    L-Valine-d8 35045-72-8 99.91%
    L-Valine-d8 is a deuterated form of L-Valine (HY-N0717). L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.
    L-Valine-d<sub>8</sub>
  • HY-N0326S5
    L-Methionine-13C5 202326-57-6 99.96%
    L-Methionine-13C5 is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
    L-Methionine-<sup>13</sup>C<sub>5</sub>
  • HY-14608S5
    L-Glutamic acid-13C5 55443-55-5 99.81%
    L-Glutamic acid-13C5 is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
    L-Glutamic acid-<sup>13</sup>C<sub>5</sub>
  • HY-14608S3
    L-Glutamic acid-13C5,15N 202468-31-3 99.9%
    L-Glutamic acid-13C5,15N is the 13C- and 15N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
    L-Glutamic acid-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N
  • HY-W010347S
    DL-Homocysteine-d4 416845-90-4 99.70%
    DL-Homocysteine-d4 is the deuterium labeled DL-Homocysteine. DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.
    DL-Homocysteine-d<sub>4</sub>
  • HY-N0215S8
    L-Phenylalanine-13C6 180268-82-0 99.8%
    L-Phenylalanine-13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-<sup>13</sup>C<sub>6</sub>
  • HY-N0486S1
    L-Leucine-13C 74292-94-7 99.4%
    L-Leucine-13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-<sup>13</sup>C
  • HY-Y0337S
    L-Cysteine-13C3,15N 202406-97-1 99.9%
    L-Cysteine-13C3,15N is the 13C- and 15N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.
    L-Cysteine-<sup>13</sup>C<sub>3</sub>,<sup>15</sup>N