L-Valine
Based on 5 publication(s) in Google Scholar
L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 72-18-4
- Formula: C5H11NO2
- Molecular Weight:117.15
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Valine
More
Customer Validation & Images
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WB
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RT-PCR
Biological Activity
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Human Endogenous Metabolite |
Microbial Metabolite |
L-Valine (0.4-40 mM, 3 h) increases the production of NO through inhibition of arginase, enhances phagocytosis by activating the PI3K/Akt1 signaling pathway[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7
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Concentration:0.4-40 mM
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Incubation Time:3 h
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Result:Increased p-Akt.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:E.coli and K. pneumoniae infected BALB/c mouse model[3]
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Dosage:0.5 g/kg
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Administration:iv, 1/4/7/10/20 hours post-infection
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Result:Reduced the bacterial load.
Chemical Information
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CAS No. 72-18-4
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Appearance Solid
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Molecular Weight 117.15
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Formula C5H11NO2
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Color White to off-white
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SMILES
N[C@@H](C(C)C)C(O)=O
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Synonyms
(S)-Valine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
J Nutr Biochem
Food-derived chlorogenic acid prevents aortic aneurysm and dissection by nutritional restore branched-chain amino acid dyshomeostasis. [Abstract]2025 Dec 6:150:110211. PMID: 41360205
L-Valine purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Dec 6:150:110211. [Abstract]
SMCs were incubated with BCAAs (3 mM, leucine:isoleucine:valine = 2:1:1) simultaneously with CGA treatment for 24 h, which increased phosphorylated mTOR and decreased α-SMA compared to the CGA group.
L-Valine purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Dec 6:150:110211. [Abstract]
Incubation of SMCs with BCAAs (3 mM, leucine:isoleucine:valine = 2:1:1) simultaneously with CGA treatment for 24 h decreased ACTA2 mRNA compared to the CGA group.
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Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313 -
Solvent & Solubility
H2O : 20 mg/mL (170.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (213.40 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. K Kirubavathi, et al. Synthesis, growth, structural, spectroscopic and optical studies of a new semiorganic nonlinear optical crystal: L-valine hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Apr;69(4):1283-6. [Content Brief]
[2]. Zhang BH, et al., L-valine, an antialgal amino acid from Streptomyces jiujiangensis JXJ 0074(T). Appl Microbiol Biotechnol. 2016 May;100(10):4627-36. [Content Brief]
[3]. Chen XH, et al., Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens. Front Immunol. 2017 Mar 6;8:207. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.5361 mL | 42.6803 mL | 85.3606 mL | 213.4016 mL |
| 5 mM | 1.7072 mL | 8.5361 mL | 17.0721 mL | 42.6803 mL | |
| 10 mM | 0.8536 mL | 4.2680 mL | 8.5361 mL | 21.3402 mL | |
| 15 mM | 0.5691 mL | 2.8454 mL | 5.6907 mL | 14.2268 mL | |
| 20 mM | 0.4268 mL | 2.1340 mL | 4.2680 mL | 10.6701 mL | |
| 25 mM | 0.3414 mL | 1.7072 mL | 3.4144 mL | 8.5361 mL | |
| 30 mM | 0.2845 mL | 1.4227 mL | 2.8454 mL | 7.1134 mL | |
| 40 mM | 0.2134 mL | 1.0670 mL | 2.1340 mL | 5.3350 mL | |
| 50 mM | 0.1707 mL | 0.8536 mL | 1.7072 mL | 4.2680 mL | |
| 60 mM | 0.1423 mL | 0.7113 mL | 1.4227 mL | 3.5567 mL | |
| 80 mM | 0.1067 mL | 0.5335 mL | 1.0670 mL | 2.6675 mL | |
| 100 mM | 0.0854 mL | 0.4268 mL | 0.8536 mL | 2.1340 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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