2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation PI3K/Akt/mTOR
  3. Bacterial Arginase Akt
  4. L-Valine

L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase.

For research use only. We do not sell to patients.

CAS No. : 72-18-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 5 publication(s) in Google Scholar

Other Forms of L-Valine:

L-Valine Related Antibodies

Top Publications Citing Use of Products

    L-Valine purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Dec 6:150:110211.  [Abstract]

    SMCs were incubated with BCAAs (3 mM, leucine:isoleucine:valine = 2:1:1) simultaneously with CGA treatment for 24 h, which increased phosphorylated mTOR and decreased α-SMA compared to the CGA group.

    L-Valine purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Dec 6:150:110211.  [Abstract]

    Incubation of SMCs with BCAAs (3 mM, leucine:isoleucine:valine = 2:1:1) simultaneously with CGA treatment for 24 h decreased ACTA2 mRNA compared to the CGA group.

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    • Purity & Documentation

    • References

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    Description

    L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    L-Valine (0.4-40 mM, 3 h) increases the production of NO through inhibition of arginase, enhances phagocytosis by activating the PI3K/Akt1 signaling pathway[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Valine Related Antibodies

    Western Blot Analysis[3]

    Cell Line: RAW264.7
    Concentration: 0.4-40 mM
    Incubation Time: 3 h
    Result: Increased p-Akt.
    In Vivo

    L-Valine (0.5 g/kg, iv, 5 doses in a day) exhibits anti-infectious activity against multidrug-resistant bacteria in mouse models[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: E.coli and K. pneumoniae infected BALB/c mouse model[3]
    Dosage: 0.5 g/kg
    Administration: iv, 1/4/7/10/20 hours post-infection
    Result: Reduced the bacterial load.
    Molecular Weight

    117.15

    Formula

    C5H11NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](C(C)C)C(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 20 mg/mL (170.72 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 8.5361 mL 42.6803 mL 85.3606 mL
    5 mM 1.7072 mL 8.5361 mL 17.0721 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (213.40 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.89%

    SDS (396 KB)

    COA (247 KB) HNMR (129 KB) RP-HPLC (243 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 8.5361 mL 42.6803 mL 85.3606 mL 213.4016 mL
    5 mM 1.7072 mL 8.5361 mL 17.0721 mL 42.6803 mL
    10 mM 0.8536 mL 4.2680 mL 8.5361 mL 21.3402 mL
    15 mM 0.5691 mL 2.8454 mL 5.6907 mL 14.2268 mL
    20 mM 0.4268 mL 2.1340 mL 4.2680 mL 10.6701 mL
    25 mM 0.3414 mL 1.7072 mL 3.4144 mL 8.5361 mL
    30 mM 0.2845 mL 1.4227 mL 2.8454 mL 7.1134 mL
    40 mM 0.2134 mL 1.0670 mL 2.1340 mL 5.3350 mL
    50 mM 0.1707 mL 0.8536 mL 1.7072 mL 4.2680 mL
    60 mM 0.1423 mL 0.7113 mL 1.4227 mL 3.5567 mL
    80 mM 0.1067 mL 0.5335 mL 1.0670 mL 2.6675 mL
    100 mM 0.0854 mL 0.4268 mL 0.8536 mL 2.1340 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Valine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Valine72-18-4(S)-ValineBacterialArginaseAktPKBProtein kinase BnonlinearsemiorganicmaterialInhibitorinhibitorinhibit

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