DL-Homocysteine-d4
Based on 1 Customer Validation
DL-Homocysteine-d4 is the deuterium labeled DL-Homocysteine. DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 416845-90-4
- Formula: C4H5D4NO2S
- Molecular Weight:139.21
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 416845-90-4
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Unlabeled Cas 6027-13-0
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Appearance Solid
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Molecular Weight 139.21
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Formula C4H5D4NO2S
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Color White to off-white
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SMILES
SC([2H])([2H])C([2H])([2H])C(N)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 25 mg/mL (179.58 mM; Need ultrasonic)
DMSO : 1 mg/mL (7.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. DL-Homocysteine, et al. Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid. J Neurosci Res. 2005 Feb 1;79(3):375-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 7.1834 mL | 35.9170 mL | 71.8339 mL | 179.5848 mL |
| 5 mM | 1.4367 mL | 7.1834 mL | 14.3668 mL | 35.9170 mL | |
| H2O | 10 mM | 0.7183 mL | 3.5917 mL | 7.1834 mL | 17.9585 mL |
| 15 mM | 0.4789 mL | 2.3945 mL | 4.7889 mL | 11.9723 mL | |
| 20 mM | 0.3592 mL | 1.7958 mL | 3.5917 mL | 8.9792 mL | |
| 25 mM | 0.2873 mL | 1.4367 mL | 2.8734 mL | 7.1834 mL | |
| 30 mM | 0.2394 mL | 1.1972 mL | 2.3945 mL | 5.9862 mL | |
| 40 mM | 0.1796 mL | 0.8979 mL | 1.7958 mL | 4.4896 mL | |
| 50 mM | 0.1437 mL | 0.7183 mL | 1.4367 mL | 3.5917 mL | |
| 60 mM | 0.1197 mL | 0.5986 mL | 1.1972 mL | 2.9931 mL | |
| 80 mM | 0.0898 mL | 0.4490 mL | 0.8979 mL | 2.2448 mL | |
| 100 mM | 0.0718 mL | 0.3592 mL | 0.7183 mL | 1.7958 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DL-Homocysteine-d4 Related Classifications
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