Choline-d9 chloride
Based on 3 publication(s) in Google Scholar
Choline-d9 chloride is the d9-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.98%
- CAS. Nr.: 61037-86-3
- Formel: C5H5D9ClNO
- Molecular Weight:148.68
-
Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-N0623S
L-Tryptophan-d5Stable Isotope -
HY-116084S
Trimethylamine N-oxide-d9Stable Isotope -
HY-N0739S1
Betaine-d9 chlorideStable Isotope -
HY-B0617S
S-Adenosyl-L-methionine-d3Stable Isotope -
HY-W010347S
DL-Homocysteine-d4Stable Isotope -
HY-B0762S
Acetyl-L-carnitine-d3 hydrochlorideStable Isotope -
HY-N0391S4
L-Citrulline-d4Stable Isotope -
HY-W017018S
L-Ornithine-d6 hydrochlorideStable Isotope -
HY-N0229S3
L-Alanine-d4Stable Isotope -
HY-W002112S
(±)-Nornicotine-d4Stable Isotope -
HY-19528S
SAH-d4Stable Isotope -
HY-W259489S
Picolinic acid-d4Stable Isotope
Publications Citing Use of MedChemExpress (MCE) Choline-d9 chloride
MoreAlle Histamine Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
|
Human Endogenous Metabolite |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS. Nr. 61037-86-3
-
Unlabeled CAS 67-48-1
-
Appearance Solid
-
Molecular Weight 148.68
-
Formel C5H5D9ClNO
-
Color Off-white to light yellow
-
SMILES
[2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-]
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Anal Chem
In Situ Derivatization Combined with DESI-MRM-MS/MS for Spatial Mapping Intratissue Amine-Containing Metabolites, Trimethylamine as a Case. [Abstract]2026 Feb 7. PMID: 41653191 -
Clin Chim Acta
SAH and SAM/SAH ratio associate with acute kidney injury in critically ill patients: A case-control study. [Abstract]2024 Jan 15:553:117726. PMID: 38110027 -
J Chromatogr B Analyt Technol Biomed Life Sci
Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS. [Abstract]2024 Aug 1:1243:124210. PMID: 38936270
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 140 mg/mL (941.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (672.59 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
-
Protocol for Open Field Test (OF)
The Open Field Test is a rodent behavioral assay that measures spontaneous locomotion, exploratory behavior, and anxiety-like behavior when an animal is placed in a novel open arena. The main readouts are total distance traveled, movement time, velocity, center-zone entries, center-zone time, peripheral-zone time, and thigmotaxis. The assay is based on the conflict between exploration of a novel environment and avoidance of exposed open areas; higher center exploration is commonly interpreted as lower anxiety-like behavior, whereas increased wall-following or peripheral occupancy is interpreted as higher anxiety-like behavior.
Reinheit & Dokumentation
-
Data Sheet (279 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.7259 mL | 33.6293 mL | 67.2585 mL | 168.1464 mL |
| 5 mM | 1.3452 mL | 6.7259 mL | 13.4517 mL | 33.6293 mL | |
| 10 mM | 0.6726 mL | 3.3629 mL | 6.7259 mL | 16.8146 mL | |
| 15 mM | 0.4484 mL | 2.2420 mL | 4.4839 mL | 11.2098 mL | |
| 20 mM | 0.3363 mL | 1.6815 mL | 3.3629 mL | 8.4073 mL | |
| 25 mM | 0.2690 mL | 1.3452 mL | 2.6903 mL | 6.7259 mL | |
| 30 mM | 0.2242 mL | 1.1210 mL | 2.2420 mL | 5.6049 mL | |
| 40 mM | 0.1681 mL | 0.8407 mL | 1.6815 mL | 4.2037 mL | |
| 50 mM | 0.1345 mL | 0.6726 mL | 1.3452 mL | 3.3629 mL | |
| 60 mM | 0.1121 mL | 0.5605 mL | 1.1210 mL | 2.8024 mL | |
| 80 mM | 0.0841 mL | 0.4204 mL | 0.8407 mL | 2.1018 mL | |
| 100 mM | 0.0673 mL | 0.3363 mL | 0.6726 mL | 1.6815 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Choline-d9 chloride Related Classifications
HY-B1337S1 Related Classifications
Powered by Bioz