Choline-d9 chloride
Based on 3 publication(s) in Google Scholar
Choline-d9 (chloride) is the deuterium labeled Choline chloride. Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 61037-86-3
- Formula: C5H5D9ClNO
- Molecular Weight:148.68
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Choline-d9 chloride
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 61037-86-3
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Unlabeled Cas 67-48-1
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Appearance Solid
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Molecular Weight 148.68
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Formula C5H5D9ClNO
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Color Off-white to light yellow
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SMILES
[2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chem
In Situ Derivatization Combined with DESI-MRM-MS/MS for Spatial Mapping Intratissue Amine-Containing Metabolites, Trimethylamine as a Case. [Abstract]2026 Feb 7. PMID: 41653191 -
Clin Chim Acta
SAH and SAM/SAH ratio associate with acute kidney injury in critically ill patients: A case-control study. [Abstract]2024 Jan 15:553:117726. PMID: 38110027 -
J Chromatogr B Analyt Technol Biomed Life Sci
Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS. [Abstract]2024 Jun 25:1243:124210. PMID: 38936270
Solvent & Solubility
DMSO : ≥ 140 mg/mL (941.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (672.59 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.7259 mL | 33.6293 mL | 67.2585 mL | 168.1464 mL |
| 5 mM | 1.3452 mL | 6.7259 mL | 13.4517 mL | 33.6293 mL | |
| 10 mM | 0.6726 mL | 3.3629 mL | 6.7259 mL | 16.8146 mL | |
| 15 mM | 0.4484 mL | 2.2420 mL | 4.4839 mL | 11.2098 mL | |
| 20 mM | 0.3363 mL | 1.6815 mL | 3.3629 mL | 8.4073 mL | |
| 25 mM | 0.2690 mL | 1.3452 mL | 2.6903 mL | 6.7259 mL | |
| 30 mM | 0.2242 mL | 1.1210 mL | 2.2420 mL | 5.6049 mL | |
| 40 mM | 0.1681 mL | 0.8407 mL | 1.6815 mL | 4.2037 mL | |
| 50 mM | 0.1345 mL | 0.6726 mL | 1.3452 mL | 3.3629 mL | |
| 60 mM | 0.1121 mL | 0.5605 mL | 1.1210 mL | 2.8024 mL | |
| 80 mM | 0.0841 mL | 0.4204 mL | 0.8407 mL | 2.1018 mL | |
| 100 mM | 0.0673 mL | 0.3363 mL | 0.6726 mL | 1.6815 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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