Trimethylamine N-oxide-d9
Based on 1 publication(s) in Google Scholar
Trimethylamine N-oxide-d9 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 1161070-49-0
- Formula: C3D9NO
- Molecular Weight:84.17
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Trimethylamine N-oxide-d9
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1161070-49-0
-
Unlabeled Cas 1184-78-7
-
Appearance Solid
-
Molecular Weight 84.17
-
Formula C3D9NO
-
Color White to off-white
-
SMILES
[2H]C([2H])([N+](C([2H])([2H])[2H])([O-])C([2H])([2H])[2H])[2H]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Chromatogr B Analyt Technol Biomed Life Sci
Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS. [Abstract]2024 Aug 1:1243:124210. PMID: 38936270
Solvent & Solubility
H2O : 100 mg/mL (1188.07 mM; Need ultrasonic)
DMSO : 100 mg/mL (1188.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Wei Shuai, et al. High-choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 May 14;S1071-9164(19)31802-0. [Content Brief]
[3]. Wenlong Yang, et al. Gut Microbe-Derived Metabolite Trimethylamine N-oxide Accelerates Fibroblast-Myofibroblast Differentiation and Induces Cardiac Fibrosis. J Mol Cell Cardiol. 2019 Sep;134:119-130. [Content Brief]
[4]. Manuel T Velasquez, et al. Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel). 2016 Nov 8;8(11):326. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 11.8807 mL | 59.4036 mL | 118.8072 mL | 297.0179 mL |
| 5 mM | 2.3761 mL | 11.8807 mL | 23.7614 mL | 59.4036 mL | |
| 10 mM | 1.1881 mL | 5.9404 mL | 11.8807 mL | 29.7018 mL | |
| 15 mM | 0.7920 mL | 3.9602 mL | 7.9205 mL | 19.8012 mL | |
| 20 mM | 0.5940 mL | 2.9702 mL | 5.9404 mL | 14.8509 mL | |
| 25 mM | 0.4752 mL | 2.3761 mL | 4.7523 mL | 11.8807 mL | |
| 30 mM | 0.3960 mL | 1.9801 mL | 3.9602 mL | 9.9006 mL | |
| 40 mM | 0.2970 mL | 1.4851 mL | 2.9702 mL | 7.4254 mL | |
| 50 mM | 0.2376 mL | 1.1881 mL | 2.3761 mL | 5.9404 mL | |
| 60 mM | 0.1980 mL | 0.9901 mL | 1.9801 mL | 4.9503 mL | |
| 80 mM | 0.1485 mL | 0.7425 mL | 1.4851 mL | 3.7127 mL | |
| 100 mM | 0.1188 mL | 0.5940 mL | 1.1881 mL | 2.9702 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Trimethylamine N-oxide-d9 Related Classifications
HY-116084S Related Classifications
Powered by Bioz