2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 5-Methyltetrahydrofolic acid

5-Methyltetrahydrofolic acid  (Synonyms: 5-Methyl THF)

Cat. No.: HY-113046 Purity: 99.29%
COA Handling Instructions

5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid.

For research use only. We do not sell to patients.

5-Methyltetrahydrofolic acid Chemical Structure

5-Methyltetrahydrofolic acid Chemical Structure

CAS No. : 134-35-0

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Solid
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100 mg USD 80 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of 5-Methyltetrahydrofolic acid:

5-Methyltetrahydrofolic acid Related Antibodies

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Description

5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

459.46

Appearance

Solid

Formula

C20H25N7O6
CAS No.
SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C)C3=C(NC(N)=NC3=O)NC2)C=C1)=O
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (181.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1765 mL 10.8823 mL 21.7647 mL
5 mM 0.4353 mL 2.1765 mL 4.3529 mL
10 mM 0.2176 mL 1.0882 mL 2.1765 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.53 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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5-Methyltetrahydrofolic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

5-Methyltetrahydrofolic acid134-35-05-Methyl THFEndogenous MetaboliteInhibitorinhibitorinhibit

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