5-Methyltetrahydrofolic acid disodium

Cat. No.: HY-137829 Purity: 88%: Data Sheet
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5-Methyltetrahydrofolic acid disodium is the metabolite of Folinic acid (Leucovorin) (HY-17556). 5-Methyltetrahydrofolic acid disodium is involved in one-carbon metabolism and the transfer of methyl groups.

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CAS No. : 68792-52-9

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1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
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Based on 8 publication(s) in Google Scholar

Other Forms of 5-Methyltetrahydrofolic acid disodium:

5-Methyltetrahydrofolic acid In-stock

8 Publications Citing Use of MCE 5-Methyltetrahydrofolic acid disodium

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: 5-Methyltetrahydrofolic acid disodium purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2023 Jan 25;51(2):952-965. [Abstract]; Thermogram of a representative ITC experiment of THF-II-loti62 binding to THF (top) and overlay of integrated fitted heat plots of THF-II-loti62 binding to THF, NPR, H4B, 7DG, folinic acid, 5-Methyltetrahydrofolic acid and 6-biopterin (bottom).

: 5-Methyltetrahydrofolic acid disodium purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Jun 6;21(1):365. [Abstract]; Gene expression levels in cells treated with 5-Methyltetrahydrofolic acid (50 μM, 12 h) and TGF-β1 as indicated were determined by RT-qPCR.

: 5-Methyltetrahydrofolic acid disodium purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Jun 6;21(1):365. [Abstract]; Lysates from cells treated with 5-Methyltetrahydrofolic acid (50 μM, 12 h) and TGF-β1 as indicated were analyzed by western blotting.

: 5-Methyltetrahydrofolic acid disodium purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Jun 6;21(1):365. [Abstract]; Concentration analysis of H₂O₂ and MDA in cells treated with 5-Methyltetrahydrofolic acid (50 μM, 12 h) and TGF-β1 as indicated.

: 5-Methyltetrahydrofolic acid disodium purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Jun 6;21(1):365. [Abstract]; Flow cytometry analysis of total intracellular ROS (DCF) and mitochondrial ROS (MitoSOX Red) in cells treated with 5-Methyltetrahydrofolic acid (50 μM, 12 h) and TGF-β1 as indicated.

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Description	5-Methyltetrahydrofolic acid disodium is the metabolite of Folinic acid (Leucovorin) (HY-17556). 5-Methyltetrahydrofolic acid disodium is involved in one-carbon metabolism and the transfer of methyl groups^[1].
Molecular Weight	503.42
Formula	C₂₀H₂₃N₇Na₂O₆
CAS No.	68792-52-9
Appearance	Solid
Color	Light yellow to yellow
SMILES	O=C(O[Na])CCC(C(O[Na])=O)NC(C1=CC=C(NCC2N(C)C3=C(NC(N)=NC3=O)NC2)C=C1)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation	Purity: 88% Select Batch: Data Sheet (266 KB) SDS (394 KB) COA (246 KB) Handling Instructions (2659 KB)
References	[1]. Schleyer E, et al., Highly sensitive coupled-column high-performance liquid chromatographic method for the separation and quantitation of the diastereomers of leucovorin and 5-methyltetrahydrofolate in serum and urine. J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):319-30. [Content Brief]