1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. Antifolate
    Endogenous Metabolite
  3. Folinic acid

Folinic acid (Synonyms: leucovorin)

Cat. No.: HY-17556
Handling Instructions

Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.

For research use only. We do not sell to patients.

Folinic acid Chemical Structure

Folinic acid Chemical Structure

CAS No. : 58-05-9

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Description

Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

In Vivo

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage: 7.0 mg/kg
Administration: Intraperitoneal injection; every second day; for 3 weeks
Result: Following methotrexate (MTX) administration appears to reverse this growth inhibition.
Clinical Trial
Molecular Weight

473.44

Formula

C₂₀H₂₃N₇O₇

CAS No.

58-05-9

SMILES

O=C(O)CC[[email protected]@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Folinic acidleucovorinAntifolateEndogenous MetaboliteInhibitorinhibitorinhibit

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Folinic acid
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HY-17556
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