1. Cell Cycle/DNA Damage
  2. Antifolate
  3. Folinic acid calcium salt pentahydrate

Folinic acid calcium salt pentahydrate (Synonyms: Leucovorin calcium salt pentahydrate)

Cat. No.: HY-B0080 Purity: 99.73%
Handling Instructions

Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.

For research use only. We do not sell to patients.

Folinic acid calcium salt pentahydrate Chemical Structure

Folinic acid calcium salt pentahydrate Chemical Structure

CAS No. : 6035-45-6

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Based on 1 publication(s) in Google Scholar

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Description

Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

In Vitro

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

In Vivo

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage: 7.0 mg/kg
Administration: Intraperitoneal injection; every second day; for 3 weeks
Result: Following methotrexate (MTX) administration appears to reverse this growth inhibition.
Clinical Trial
Molecular Weight

603.59

Formula

C₂₀H₃₃CaN₇O₁₂ ₂+

CAS No.

6035-45-6

SMILES

O=CN1C(C2=O)=C(NC(N)=N2)NCC1CNC3=CC=C(C(N[[email protected]](C(O)=O)CCC(O)=O)=O)C=C3.O.O.O.O.[Ca+2].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (16.57 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6568 mL 8.2838 mL 16.5675 mL
5 mM 0.3314 mL 1.6568 mL 3.3135 mL
10 mM 0.1657 mL 0.8284 mL 1.6568 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Folinic acid calcium saltLeucovorin calcium saltAntifolateInhibitorinhibitorinhibit

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Folinic acid calcium salt pentahydrate
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HY-B0080
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