1. Cell Cycle/DNA Damage
  2. Antifolate
  3. Folinic acid Calcium

Folinic acid Calcium (Synonyms: Leucovorin Calcium; Calcium Folinate)

Cat. No.: HY-13664 Purity: 99.73%
Handling Instructions

Leucovorin Calcium is a reduced folic acid.

For research use only. We do not sell to patients.

Folinic acid Calcium Chemical Structure

Folinic acid Calcium Chemical Structure

CAS No. : 1492-18-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Folinic acid Calcium:

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Description

Leucovorin Calcium is a reduced folic acid. IC50 Value: 30 μM for zcSHMT and70 μM for zmSHMT [2] Target: Antifolate in vitro: Increasing concentrations of leucovorin (N5-CHO-THF) inhibit both zcSHMT and hcSHMT activities substantially, yet to a lesser extent than zmSHMT. The IC50 of leucovorin is approximately 30 μM for zcSHMT and higher than 70 μM for zmSHMT. The differential inhibition is evident with the presence of 10 μM leucovorin, the concentration estimated in serum in a high-dose leucovorin rescue regimen [2]. in vivo: Following intravenous administration, peak plasma concentrations of (6R) LV, (6S) LV, and 5-CH3 THF were 148 +/- 32, 59.1 +/- 22, and 17.8 +/- 17 microM, respectively. During oral administration of LV, virtually no (6S) LV appeared in the plasma. Steady-state plasma concentrations of (6R) LV and 5-CH3 THF were approximately 1.5 +/- 0.23 and 2.8 +/- 0.41 microM, respectively [1]. 24 fasted subjects were given 4 of a series of 5 single test doses between 20 and 100 mg, at 1-week intervals, of 5-formyl-THF as an oral solution of leucovorin calcium. Six separate subjects received 200 mg iv and po in a 2-way crossover. Blood and urine samples were collected over 24 hours for differential microbiological folate assays using Lactobacillus casei and Streptococcus faecalis. Using L casei activity to measure total serum folates, the area under the concentration-time curve from 0 to infinite time (AUC[0-infinity]) was calculated. Relative bioavailabilities were 78%, 62%, 49%, and 42% for the 40-, 60-, 80-, and 100-mg doses, respectively [3]. Clinical trial: Leucovorin and Fluorouracil With or Without SU-5416 in Treating Patients With Metastatic Colorectal Cancer . Phase 3

Clinical Trial
Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (391.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9550 mL 9.7752 mL 19.5503 mL
5 mM 0.3910 mL 1.9550 mL 3.9101 mL
10 mM 0.1955 mL 0.9775 mL 1.9550 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

511.50

Formula

C₂₀H₂₁CaN₇O₇

CAS No.

1492-18-8

SMILES

O=C(N[[email protected]](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.73%

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Product Name:
Folinic acid Calcium
Cat. No.:
HY-13664
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Folinic acid Calcium

Cat. No.: HY-13664