1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. Antifolate
    Endogenous Metabolite
  3. Folinic acid calcium

Folinic acid calcium (Synonyms: Leucovorin calcium; Calcium folinate)

Cat. No.: HY-13664 Purity: 99.73%
Handling Instructions

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.

For research use only. We do not sell to patients.

Folinic acid calcium Chemical Structure

Folinic acid calcium Chemical Structure

CAS No. : 1492-18-8

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Based on 1 publication(s) in Google Scholar

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Description

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].

In Vivo

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage: 7.0 mg/kg
Administration: Intraperitoneal injection; every second day; for 3 weeks
Result: Following methotrexate (MTX) administration appears to reverse this growth inhibition.
Clinical Trial
Molecular Weight

511.50

Formula

C₂₀H₂₁CaN₇O₇

CAS No.

1492-18-8

SMILES

O=C(N[[email protected]](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (391.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9550 mL 9.7752 mL 19.5503 mL
5 mM 0.3910 mL 1.9550 mL 3.9101 mL
10 mM 0.1955 mL 0.9775 mL 1.9550 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.73%

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Folinic acid calcium
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HY-13664
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